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Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects

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Pasteurella multocida

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 361))

Abstract

The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric Gq-, Gi- and G12/13-proteins, PMT potently stimulates downstream mitogenic, calcium, and cytoskeletal signaling pathways. These activities lead to pleiotropic effects in different cell types, which ultimately result in cellular proliferation, while inhibiting cellular differentiation, and account for the myriad of physiological outcomes observed during infection with toxinogenic strains of P. multocida.

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Acknowledgments

Some of the work reported here was supported by grants from the National Institutes of Health (NIH/NIAID AI038396) and the US Department of Agriculture (NRI 1999-02295) (to B.A.W.).

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  1. Department of Microbiology and the Host-Microbe Systems Theme of the Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA

    Brenda A. Wilson & Mengfei Ho

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  1. Brenda A. Wilson
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  2. Mengfei Ho
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Correspondence to Brenda A. Wilson .

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Editors and Affiliations

  1. Inst. Experimentelle und Klinische, Pharmakologie und Toxikologie, Universität Freiburg, Albertstr. 25, Freiburg, 79104, Germany

    Klaus Aktories

  2. , Experimentelle und Klinische Pharmakolog, University of Freiburg, Albertstr. 25, Freiburg, 79104, Germany

    Joachim H.C. Orth

  3. , Dept. of Microbiology, Monash University, Melbourne, Victoria, Australia

    Ben Adler

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Wilson, B.A., Ho, M. (2012). Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects. In: Aktories, K., Orth, J., Adler, B. (eds) Pasteurella multocida. Current Topics in Microbiology and Immunology, vol 361. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_219

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