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Role of ADARs in Mouse Development

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Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 353)

Abstract

RNA editing by deamination of adenosine to inosine (A-to-I editing) is a physiologically important posttranscriptional mechanism that can regulate expression of genes by modifying their transcripts. A-to-I editing is mediated by adenosine deaminases acting on RNA (ADAR) that can catalytically exchange adenosines to inosines, with varying efficiency, depending on the structure of the RNA substrates. Significant progress in understanding the biological function of mammalian ADARs has been made in the past decade by the creation and analysis of gene-targeted mice with disrupted or modified ADAR alleles. These studies have revealed important roles of ADARs in neuronal and hematopoietic tissue during embryonic and postnatal stages of mouse development.

Keywords

Amyotrophic Lateral Sclerosis Fetal Liver Amyotrophic Lateral Sclerosis Patient Adenosine Deaminase Blood Cell Lineage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgments

Work in C.R.W’s laboratory is supported by grants from the National Health and Medical Research Council (NHMRC) Australia; C.R.W. is the Philip Desbrow Seniro Research Fellow of the Leukaemia Foundation.

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© Springer-Verlag Berlin Heidelberg  2011

Authors and Affiliations

  1. 1.St. Vincent’s Institute of Medical Research and Department of MedicineSt. Vincent’s Hospital, University of MelbourneMelbourneAustralia
  2. 2.TaconicArtemis GmbHKoelnGermany

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