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The Caliciviruses

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 343))

Abstract

The caliciviruses are by far the major cause of non-bacterial gastroenteritis, highly infectious, and have a rapid and severe onset of symptoms. Studies on this family of viruses have been hampered by the lack of animal model and tissue culture system. However, recent advances in protein expression systems and the development of a mouse norovirus animal model has led to rapid advances in our understanding of these viruses with regard to structure and the host immune response. Our current understanding of this important family of viruses is reviewed here.

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References

  • Ball JM, Graham DY, Opekun AR, Gilger MA, Guerrero RA, Estes MK (1999) Recombinant Norwalk virus-like particles given orally to volunteers: phase I study. Gastro 117:40–48

    Article  CAS  Google Scholar 

  • Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW (1997) Isolation of a common receptor for coxsackie B viruses and Adenoviruses 2 and 5. Science 275:1320–1323

    Article  CAS  PubMed  Google Scholar 

  • Bertolotti-Ciarlet A, White LJ, Chen R, Prasad BVV, Estes MK (2002) Structural requirements for the assembly of Norwalk virus-like particles. J Virol 76:4044–4055

    Article  CAS  PubMed  Google Scholar 

  • Bhella D, Gatherer D, Chaudhry Y, Pink R, Goodfellow IG (2008) Structural insights into calicivirus attachment and uncoating. J Virol 82:8051–8058

    Article  CAS  PubMed  Google Scholar 

  • Black RE, Greenberg HB, Kapikian AZ, Brown KH, Becker S (1982) Acquisition of serum antibody to Norwalk virus and rotavirus and relation to diarrhea in a longitudinal study of young children in rural Bangladesh. J Infect Dis 145:483–489

    Article  CAS  PubMed  Google Scholar 

  • Blacklow NR, Dolin R, Fedson DS, DuPont H, Northrup RS, Hornick RB, Chanock RM (1972) Acute infectious nonbacterial gastroenteritis: etiology and pathogenesis. A combined clinical staff conference at the Clinical Center of the National Institutes of Heath. Ann Intern Med 76:993–1008

    Google Scholar 

  • Bu W, Mamedova A, Tan M, Xia M, Jiang X, Hegde RS (2008) Structural basis for the receptro binding specificity of Norwalk virus. J Virol 82:5340–5347

    Article  CAS  PubMed  Google Scholar 

  • Cao S, Lou Z, Tan M, Chen Y, Liu Y, Zhang Z, Zhang X, Jiang X, Li Z, Rao Z (2007) Structural basis for the recognition of blood group trisaccarides by norovirus. J Virol 81:5949–5957

    Article  CAS  PubMed  Google Scholar 

  • Chachu KA, Strong DW, LoBue AE, Wobus CE, Baric RS, Virgin HWI (2008) Antibody is critical for the clearance of murine norovirus infection. J Virol 82:6610–6617

    Article  CAS  PubMed  Google Scholar 

  • Che Z, Olson NH, Leippe D, Lee W-M, Mosser A, Rueckert RR, Baker TS, Smith TJ (1998) Antibody-mediated neutralization of human rhinovirus 14 explored by means of cryo-electron microscopy and X-ray crystallography of virus-Fab complexes. J Virol 72:4610–4622

    CAS  PubMed  Google Scholar 

  • Chen R, Neill JD, Prasad BVV (2002) Crystallization and preliminary crystallographic analysis of San Miguel sea lion virus: an animal calicivirus. J Struct Biol 141:143–148

    Article  Google Scholar 

  • Chen R, Neill JD, Estes MK, Prasad BVV (2006) X-ray structure of a native calicivirus: structural insights into antigenic diversity and host spcificity. Proc Natl Acad Sci USA 103:8048–8053

    Article  CAS  PubMed  Google Scholar 

  • Choi J-M, Hutson AM, Estes MK, Prasad BVV (2008) Atomic resolution structural characterization of recognition of histo-blood group antigens by Norwalk virus. Proc Natl Acad Sci 105:9175–9180

    Article  CAS  PubMed  Google Scholar 

  • Clarke SD, Baillie R, Jump DB, Nakamura MT (1997) Fatty acid regulation of gene expression. Its role in fuel partitioning and insulin resistance. Ann N Y Acad Sci 827:178–187

    Article  CAS  PubMed  Google Scholar 

  • Dolin R, Blacklow NR, DuPont H, Formal S, Buscho RF, Kasel JA, Chames RP, Hornick R, Chanock RM (1971) Transmission of acute infectious nonbacterial gastroenteritis to volunteers by oral administration of stool filtrates. J Infect Dis 123:307–312

    Article  CAS  PubMed  Google Scholar 

  • Dolin R, Blacklow NR, Dupont H, Buscho RF, Wyatt RG, Kasel JA, Hornick R, Chanock RM (1972) Biological properties of Norwalk agent of acute infectious nonbacterial gastroenteritis. Proc Soc Exp Biol Med 140:578–583

    CAS  PubMed  Google Scholar 

  • Evander M, Frazer IH, Payne E, Qi YM, Hengst K, McMillan NAJ (1997) Identification of the a6 integrin as a candidate receptor for papillomaviruses. J Virol 71:2449–2456

    CAS  PubMed  Google Scholar 

  • Graham DY, Jiang X, Tanaka T, Opekun AR, Madore HP, Estes MK (1994) Norwalk virus infection of volunteers: new insights based on improved assays. J Infect Dis 170:34–43

    Article  CAS  PubMed  Google Scholar 

  • Green KY, Lew JF, Jiang X, Kapikian AZ, Estes MK (1993) Comparison of the reactivities of baculovirus-expressed recombinant Norwalk virus capsid antigen with those of the native Norwalk virus antigen in serologic assays and some epidemiologic observations. J Clin Microbiol 31:2185–2191

    CAS  PubMed  Google Scholar 

  • Green KY, Kapikian AZ, Valdesuso J, Sosnovtsev S, Treanor JJ, Lew JF (1997) Expression and self-assembly of recombinant capsid protein from the antigenically distinct Hawaii human calicivirus. J Clin Microbiol 35:1909–1914

    CAS  PubMed  Google Scholar 

  • Hardy ME, Estes MK (1996) Completion of the Norwalk virus genome sequence. Virus Genes 12:287–290

    Article  CAS  PubMed  Google Scholar 

  • Harrington PR, Lindesmith L, Yount B, Moe CL, Baric RS (2002) Binding of Norwalk virus-like particles to ABH histo-blood group antigens is blocked by antisera from infected human volunteers or experimentally vaccinated mice. J Virol 76:12335–12343

    Article  CAS  PubMed  Google Scholar 

  • Hillman BB, Morris TJ, Kellen WR, Hoffman D, Schlegel DE (1982) An invertebrate calici-like virus: evidence for partial virion disintegration in host excreta. J Gen Virol 60:115–123

    Article  CAS  Google Scholar 

  • Huang P, Farkas T, Marionneau S, Zhong W, Ruvoen-Clouet N, Morrow AL, Altaye M, Pickering LK, Newburg DS, LePendu J, Jiang X (2003) Noroviruses bind to human ABO, Lewis, and secretor histo–blood group antigens: identification of 4 distinct strain-specific patterns. J Infect Dis 188:19–31

    Article  CAS  PubMed  Google Scholar 

  • Hutson AM, Atmar RL, Estes MK (2004) Norovirus disease: changing epidemiology and host susceptibility factors. Trends Microbiol 12:279–287

    Article  CAS  PubMed  Google Scholar 

  • Jackson T, Mould AP, Sheppard D, King AMQ (2001) Integrin avb1 is a receptor for foot-and-mouth disease virus. J Virol 76:935–941

    Article  Google Scholar 

  • Jiang X, Graham DY, Wang KN, Estes MK (1990) Norwalk virus genome cloning and characterization. Science 250:1580–1583

    Article  CAS  Google Scholar 

  • Jiang X, Wang M, Wang K, Estes MK (1993) Sequence and genomic organization of Norwalk virus. Virology 195:51–61

    Article  CAS  PubMed  Google Scholar 

  • Jiang X, Matson DO, Ruiz-Palacios GM, Hu J, Treanor J, Pickering LK (1995) Expression, self-assembly, and antigenicity of a snow mountain agent- like calicivirus capsid protein. J Clin Microbiol 33:1452–1455

    CAS  PubMed  Google Scholar 

  • Jiang X, Zhong WM, Farkas T, Huang PW, Wilton N, Barrett E, Fulton D, Morrow R, Matson DO (2002) Baculovirus expression and antigenic characterization of the capsid proteins of three Norwalk-like viruses. Arch Virol 147:119–130

    Article  CAS  PubMed  Google Scholar 

  • Kaplan JE, Gary GW, Baron RC, Singh N, Schrongerger LB, Feldman R, Greenberg HB (1982) Epidemiology of Norwalk gastroenteritis and the role of Norwalk virus in outbreaks of acute nonbacterial gastroenteritis. Ann Intern Med 96:756–761

    CAS  PubMed  Google Scholar 

  • Karst SM, Wobus CE, Lay M, Davidson J, Virgin HWI (2003) STAT1-dependent innate immunity to a Norwalk-like virus. Science 299:1575–1578

    Article  CAS  PubMed  Google Scholar 

  • Katpally U, Smith TJ (2007) Pocket factors unlikely play a major role in the life cycle of human rhinovirus. J Virol 81:6307–6315

    Article  CAS  PubMed  Google Scholar 

  • Katpally U, Wobus CE, Dryden K, Virgin HWI, Smith TJ (2007) Unexpected structural differences between authentic norovirus and virus like particles. J Virol 82:2079–2088

    Article  PubMed  Google Scholar 

  • Katze MG, He Y, Gale MJ (2002) Viruses and interferon: a fight for supremecy. Nat Rev Immunol 2:675–687

    Article  CAS  PubMed  Google Scholar 

  • Klimstra WB, Ryman KD, Johnston RE (1998) Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor. J Virol 72:7357–7366

    CAS  PubMed  Google Scholar 

  • Laurent S, Vautherot JF, Madelaine MF, Le Gall G, Rasschaert D (1994) Recombinant rabbit hemorrhagic disease virus capsid protein expressed in baculovirus self assembles into virus like particles and induces protection. J Virol 68:6794–6798

    CAS  PubMed  Google Scholar 

  • Leite JP, Ando T, Noel JS, Jiang B, Humphrey CD, Lew JF, Green KY, Glass RI, Monroe SS (1996) Characterization of Toronto virus capsid protein expressed in baculovirus. Arch Virol 141:865–875

    Article  CAS  PubMed  Google Scholar 

  • Libbey JE, McCright IJ, Tsunoda I, Wada Y, Fujinami RS (2001) Peripheral nerve protein, P0, as a potential receptor for Theiler’s murine encephalomyelitis virus. J Neurovirol 7:97–104

    Article  CAS  PubMed  Google Scholar 

  • Lindesmith L, Moe C, Marionneau S, Ruvoen N, Jiang X, Lindblad L, Stewart P, LePendu J, Baric R (2003) Human susceptibility and resistance to Norwalk virus infection. Nat Med 9:548–553

    Article  CAS  PubMed  Google Scholar 

  • Liu H, Smith TJ, Lee WM, Mosser A, Rueckert RR, Olson NH, Cheng RH, Baker TS (1994) Structure determination of an fab fragment that neutralizes human rhinovirus 14 and analysis of the fab-virus complex. J Mol Biol 240:127–137

    Article  CAS  PubMed  Google Scholar 

  • Makino A, Shimojima M, Miyazawa T, Kato K, Tohya Y, Akashi H (2006) Junctional adhesion molecule 1 is a functional receptor for feline calicivirus. J Virol 80:4482–4490

    Article  CAS  PubMed  Google Scholar 

  • Marionneau S, Ruvoen N, Le Moullac-Vaidye B, Clement M, Cailleau-Thomas A, Ruiz-Palacois GPH, Jiang X, Le Pendu J (2002) Norwalk virus binds to histo-blood group antigens present on gastroduodenal epithelial cells of secretor individuals. Gastroenterology 122:1967–1977

    Article  CAS  PubMed  Google Scholar 

  • Mason HS, Ball JM, Shi J-J, Jiang X, Estes MK, Arntzen CJ (1996) Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc Natl Acad Sci USA 93:5335–5340

    Article  CAS  PubMed  Google Scholar 

  • Miller LC, Verdaguer N, Mateu MG, Domingo E (2001) Role of teh cytoplasmic domain of the b-subunit of integrin avb6 in infection b foot-and-mouth disease virus. J Virol 75:4158–4164

    Article  CAS  PubMed  Google Scholar 

  • Moe CL, Sobsey MD, Stewart PW, Crawford-Brown D (1999). Estimating the risk of human calicivirus infection from drinking water. In: International workshop on human caliciviruses, Atlanta, GA, pp P4–P6

    Google Scholar 

  • Nagesha HS, Wang LF, Hyatt AD (1999) Virus-like particles of calicivirus as epitope carriers. Arch Virol 144:2429–2439

    Article  CAS  PubMed  Google Scholar 

  • Nakata S, Chiba S, Terashima H, Yokoyama T, Nakao T (1985) Humoral immunity in infants with gastroenteritis caused by human caliciviruses. J Infect Dis 152:274–279

    Article  CAS  PubMed  Google Scholar 

  • O’Donnell V, LaRocco M, Baxt B (2008) Heparan sulfate-binding food-and-mouth disease virus enters cells via caveola-mediated endocytosis. J Virol 82:9075–9085

    Article  PubMed  Google Scholar 

  • Olson NH, Kolatkar PR, Oliveira MA, Cheng RH, Greve JM, McClelland A, Baker TS, Rossmann MG (1993) Structure of a human rhinovirus complexed with its receptor molecule. Proc Natl Acad Sci 90:507–511

    Article  CAS  PubMed  Google Scholar 

  • Ossiboff RJ, Parker JS (2007) Identification of regions and residues in feline junctional adhesion molecule required for feline calicivurs binding and infection. J Virol 81:13608–13621

    Article  CAS  PubMed  Google Scholar 

  • Parrino TA, Schreiber DS, Trier JS, Kapikian AZ, Blacklow NR (1977) Clinical immunity in acute gastroenteritis caused by the Norwalk agent. N Engl J Med 297:86–89

    Article  CAS  PubMed  Google Scholar 

  • Perinstein A, Roivainen M, Hovi T, Mason PV, Baxt B (1995) Antibodies to the vitronectin receptor (integrin avb3) inhibit binding and infection of foot-and-mouth dissease to cultured cells. J Virol 69:2664–2666

    Google Scholar 

  • Prasad BV, Matson DO, Smith AW (1994) Three-dimensional structure of calicivirus. J Mol Biol 240:256–264

    Article  CAS  PubMed  Google Scholar 

  • Prasad BVV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK (1999) X-ray crystallographic structure of the Norwalk virus capsid. Science 286:287–290

    Article  CAS  PubMed  Google Scholar 

  • Prasad BVV, Hardy ME, Estes MK (2000) Structural studies of recombinant Norwalk capsids. J Infect Dis 181:S317–S321

    Article  CAS  Google Scholar 

  • Prota AE, Campbell JA, Schelling P, Forrest JC, Watson MJ, Peters TR, Aurrand-Lions M, Imhof BA, Dermondy TS, Shehle T (2003) Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding. Proc Natl Acad Sci 100:5366–5371

    Article  CAS  PubMed  Google Scholar 

  • Radford AD, Coyne KP, Dawson S, Porter CJ, Gaskell RM (2007) Feline calicivirus. Vet Res 38:319–335

    Article  CAS  PubMed  Google Scholar 

  • Reddi HV, Lipton HL (2002) Heparan sulfate mediates infection of high-neurovirulence Theiler’s viruses. J Virol 76:8400–8407

    Article  CAS  PubMed  Google Scholar 

  • Ryder RW, Singh N, Reeves WC, Kapikian AZ, Greenberg HB, Sack RB (1985) Evidence of immunity induced by natrually acquired rotavirus and Norwalk virus infection on two remote Panamanian islands. J Infect Dis 151:99–105

    Article  CAS  PubMed  Google Scholar 

  • Sa-Carvalho D, Rieder E, Baxt B, Rodarte R, Tanuri A, Mason PW (1997) Tissue culture adaptation of foot-and-mouth disease virus selects viruses that bind to heparin and are attenuated in cattle. J Virol 71:5115–5123

    CAS  PubMed  Google Scholar 

  • Sharp TW, Hyams KC, Watts D, Savarino SJ, Trofa AF, Martin GJ, Kapikian AZ, Green KJ, Jiang X, Estes MK, Waack M (1995) Epidemiology of Norwalk virus during an outbreak of acute gastroenteritis aboard a US aircraft carrier. J Med Virol 45:61–67

    Article  CAS  PubMed  Google Scholar 

  • Smith TJ, Olson NH, Cheng RH, Chase ES, Baker TS (1993) Structure of a human rhinovirus-bivalently bound antibody complex: implications for virus neutralization and antibody flexibility. Proc Natl Acad Sci USA 90:7015–7018

    Article  CAS  PubMed  Google Scholar 

  • Steinhoff MC, Douglas RGJ, Greenberg HB (1980) Bismuth subsalicylate therapy of viral gastroenteritis. Gastroenterology 78:1495–1499

    CAS  PubMed  Google Scholar 

  • Stuart AD, Brown TD (2007) Alpha 2, 6-linked sialic acid acts as a receptor for feline calicivirus. J Gen Virol 88:177–186

    Article  CAS  PubMed  Google Scholar 

  • Sturzenbecker LJ, Nibert M, Furlong D, Fields BN (1987) Intracellular digestion of reovirus particles requires a low pH and is an essential step in the viral infectious cycle. J Virol 61:2351–2361

    CAS  PubMed  Google Scholar 

  • Summerford C, Bartlett JS, Samulski RJ (1999) AlphaVbeta5 integrin: a coreceptor for adeno-associated virus type 2 infection. Nat Med 5:78–82

    Article  CAS  PubMed  Google Scholar 

  • Tacket CO, Mason HS, Losonsky G, Estes MK, Levine MM, Arntzen CJ (2000) Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. J Infect Dis 182:302–305

    Article  CAS  PubMed  Google Scholar 

  • Tan M, Huang P, Meller J, Zhong W, Farkas T, Jiang X (2003) Mutations within the P2 domain of norovirus capsid affect binding to human histo-blood group antigens: evidence for a binding pocket. J Virol 77:12562–12571

    Article  CAS  PubMed  Google Scholar 

  • Tan M, Hegde RS, Jiang X (2004) The P domain of norovirus capsid protein forms dimer and ibnds to histo-blood group antigen receptors. J Virol 78:6233–6242

    Article  CAS  PubMed  Google Scholar 

  • Tan M, Fang P, Chachiyo T, Xia M, Huang P, Fang Z, Jiang W, Jiang X (2008) Noroviral P particle: structure, function and applications in virus-host interaction. Virology 382:115–123

    Article  CAS  PubMed  Google Scholar 

  • Taniguchi K, Urasawa S, Urasawa T (1981) Further studies of 35–40 nm virus-like particles associated with outbreaks of acute gastroenteritis. J Med Microbiol 14:107–118

    Article  CAS  PubMed  Google Scholar 

  • Thornhill TS, Kalica AR, Wyatt RG, Kapikian AZ, Chanock RM (1975) Pattern of shedding of the Norwalk particle in stools during experimentally induced gastroenteritis in volunteers as determined by immune electron microscopy. J Infect Dis 132:28–34

    Article  CAS  PubMed  Google Scholar 

  • Thouvenin E, Laurent S, Madelaine M-F, Rasschaert D, Vautherot J-F, Hewat EA (1997) Bivalent binding of a neutralizing antibody to a calicivirus involves the torsional flexibility of the antibody hinge. J Mol Biol 270:238–246

    Article  CAS  PubMed  Google Scholar 

  • White LJ, Ball JM, Hardy ME, Tanaka TN, Kitamoto N, Estes MK (1996) Attachment and entry of recombinant Norwalk virus capsids to cultured human and animal cell lines. J Virol 70:6589–6597

    CAS  PubMed  Google Scholar 

  • White LJ, Hardy ME, Estes MK (1997) Biochemical characterization of a smaller form of recombinant Norwalk virus capsids assembled in insect cells. J Virol 71:8066–8072

    CAS  PubMed  Google Scholar 

  • Wobus CE, Karst SM, Thackray LB, Chang K-O, Sosnovtsev SV, Belliot G, Krug A, Mackensie JM, Green KY, Virgin HWI (2004) Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages. PLoS Biol 2:e432

    Article  PubMed  Google Scholar 

  • Wobus CE, Thackray LB, Virgin HWI (2006) Murine norovirus: a model system to study norovirus biology and pathogenesis. J Virol 80:5104–5112

    Article  CAS  PubMed  Google Scholar 

  • Wyatt RG, Dolin R, Blacklow NR, DuPont H, Buscho RF, Thornhill TS, Kapikian ZA, Chanock RM (1974) Comparison of three agents of acute infectious nonbacterial gastroenteritis by cross-challenge in volunteers. J Infect Dis 129:709–714

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Thomas J. Smith .

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Katpally, U., Smith, T.J. (2010). The Caliciviruses. In: Johnson, J. (eds) Cell Entry by Non-Enveloped Viruses. Current Topics in Microbiology and Immunology, vol 343. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_36

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