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The Chemokine System in Experimental and Clinical Hematology

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The Chemokine System in Experimental and Clinical Hematology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 341))

Abstract

The chemokine family consists of approximately 50 small (8–14 kDa), basic proteins that are expressed and released by a wide range of normal and malignant cells. Based on their molecular structure, these cytokines are divided into the two major subgroups CCL and CXCL chemokines that bind to CCR or CXCR receptors, respectively. These mediators are important for regulation of cell viability, proliferation, differentiation, and migration. Chemokines are important for cell migration during embryogenesis; they are involved in the regulation of complex processes like local recruitment of inflammatory cells, angiogenesis, and regulation of normal as well as leukemic hematopoiesis. Chemokines can be constitutively released by malignant hematopoietic cells as well as by bone marrow stromal cells. This bidirectional crosstalk between malignant hematopoietic cells and neighboring stromal cells may therefore be important for the development and clinical presentation of malignant diseases, and the chemokines or their receptors may also represent a target for specific anticancer therapy at the molecular level.

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Abbreviations

AML:

Acute myeloid leukemia

DARC:

Duffy antigen receptor for chemokines

GM-CSF:

Granulocyte-macrophage colony-stimulating factor

GVHD:

Graft vs. host disease

IFN:

Interferon

IL:

Interleukin

MMP:

Matrix metalloprotease

SNP:

Single nucleotide polymorphism

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Acknowledgments

The work was supported by the Norwegian Cancer Society and the Solveig and Ove Lunds Foundation.

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Authors and Affiliations

  1. Section for Hematology, Institute of Internal Medicine, University of Bergen, Bergen, Norway

    Øystein Bruserud & Astrid Olsnes Kittang

  2. Division of Hematology, Department of Medicine, Haukeland University Hospital, 5021, Bergen, Norway

    Øystein Bruserud & Astrid Olsnes Kittang

Authors
  1. Øystein Bruserud
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  2. Astrid Olsnes Kittang
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Corresponding author

Correspondence to Øystein Bruserud .

Editor information

Editors and Affiliations

  1. Dept. Medicine, Div. Infectious Diseases, Haukeland University Hospital, Bergen, 5021, Norway

    Oystein Bruserud

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Bruserud, Ø., Kittang, A.O. (2010). The Chemokine System in Experimental and Clinical Hematology. In: Bruserud, O. (eds) The Chemokine System in Experimental and Clinical Hematology. Current Topics in Microbiology and Immunology, vol 341. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_18

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