Abstract
The histamine research community has in the last decade been very active and generated a number of exciting new chemical biology tools for the study of histamine receptors, their ligands, and their pharmacology. In this paper we describe the development of histamine receptor structural biology, the use of receptor conformational biosensors, and the development of new ligands for covalent or fluorescent labeling or for photopharmacological approaches (photocaging and photoswitching). These new tools allow new approaches to study histamine receptors and hopefully will lead to better insights in the molecular aspects of histamine receptors and their ligands.
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Acknowledgements
We acknowledge funding from European Union’s project FLAG-ERA JTC2019 HA-CTion and project of TOPPUNT, “7 ways to 7TMR modulation (7-to-7)”, 718.014.002 supported by The Netherlands Organization for Scientific Research (NWO). Y.Z. and M.X. acknowledge the China Scholarship Council (CSC) for funding (Grant No. 201506220185 and 201703250074).
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Zheng, Y., Wágner, G., Hauwert, N., Ma, X., Vischer, H.F., Leurs, R. (2022). New Chemical Biology Tools for the Histamine Receptor Family. In: Yanai, K., Passani, M.B. (eds) The Functional Roles of Histamine Receptors. Current Topics in Behavioral Neurosciences, vol 59. Springer, Cham. https://doi.org/10.1007/7854_2022_360
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