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Anhedonia in Eating Disorders

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Anhedonia: Preclinical, Translational, and Clinical Integration

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 58))

Abstract

Anhedonia is frequently observed among individuals with eating disorders (ED), though its relevance to ED pathology and clinical outcomes remain poorly understood. This chapter will present the latest findings regarding anhedonia in ED, with the majority of data available for anorexia nervosa (AN) and bulimia nervosa (BN). We consider anhedonia from the mechanistic lens of altered reward processing, with attention given to subjective experience, neurotransmitter function, neural correlates, and cognitive performance corresponding to distinct components of reward (i.e., liking, wanting, and learning). Findings from animal models are also highlighted. The chapter concludes with a discussion of implications for treatment and future directions aimed at better understanding anhedonia in ED.

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Acknowledgments

None of the authors have conflicts of interest to disclose. This work was supported in part by grants from the National Institute of Mental Health (R01MH113588 to CEW, R21MH118409 to CEW). The contents of this manuscript are solely the responsibility of the authors and do not necessarily represent the official view of the NIH.

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Authors and Affiliations

  1. Department of Psychiatry, University of California San Diego, UCSD Eating Disorders Center for Treatment and Research, San Diego, CA, USA

    Susan M. Murray, Carina S. Brown, Walter H. Kaye & Christina E. Wierenga

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  1. Susan M. Murray
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  2. Carina S. Brown
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  3. Walter H. Kaye
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  4. Christina E. Wierenga
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Correspondence to Christina E. Wierenga .

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  1. Harvard Medical School and McLean Hospital, Belmont, MA, USA

    Diego A. Pizzagalli

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Murray, S.M., Brown, C.S., Kaye, W.H., Wierenga, C.E. (2022). Anhedonia in Eating Disorders. In: Pizzagalli, D.A. (eds) Anhedonia: Preclinical, Translational, and Clinical Integration. Current Topics in Behavioral Neurosciences, vol 58. Springer, Cham. https://doi.org/10.1007/7854_2021_287

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