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Neuroanatomic and Functional Neuroimaging Findings

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Bipolar Disorder: From Neuroscience to Treatment

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 48))

Abstract

The search for brain morphology findings that could explain behavioral disorders has gone through a long path in the history of psychiatry. With the advance of brain imaging technology, studies have been able to identify brain morphology and neural circuits associated with the pathophysiology of mental illnesses, such as bipolar disorders (BD). Promising results have also shown the potential of neuroimaging findings in the identification of outcome predictors and response to treatment among patients with BD. In this chapter, we present brain imaging structural and functional findings associated with BD, as well as their hypothesized relationship with the pathophysiological aspects of that condition and their potential clinical applications.

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References

  • Abe C, Liberg B, Song J, Bergen SE, Petrovic P, Ekman CJ, Sellgren CM, Ingvar M, Landen M (2019) Longitudinal cortical thickness changes in bipolar disorder and the relationship to genetic risk, mania, and lithium use. Biol Psychiatry 87(3):271–281. https://doi.org/10.1016/j.biopsych.2019.08.015

    Article  PubMed  Google Scholar 

  • Abramovic L, Boks MPM, Vreeker A, Verkooijen S, van Bergen AH, Ophoff RA, Kahn RS, van Haren NEM (2018) White matter disruptions in patients with bipolar disorder. Eur Neuropsychopharmacol 28(6):743–751. https://doi.org/10.1016/j.euroneuro.2018.01.001

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Adler CM, Holland SK, Schmithorst V, Wilke M, Weiss KL, Pan H, Strakowski SM (2004) Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study. Bipolar Disord 6(3):197–203. https://doi.org/10.1111/j.1399-5618.2004.00108.x

    Article  PubMed  Google Scholar 

  • Adler CM, Adams J, DelBello MP, Holland SK, Schmithorst V, Levine A, Jarvis K, Strakowski SM (2006) Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: a diffusion tensor imaging study. Am J Psychiatry 163(2):322–324. https://doi.org/10.1176/appi.ajp.163.2.322

    Article  PubMed  Google Scholar 

  • Alexander AL, Lee JE, Lazar M, Field AS (2007) Diffusion tensor imaging of the brain. Neurotherapeutics 4(3):316–329. https://doi.org/10.1016/j.nurt.2007.05.011

    Article  PubMed  PubMed Central  Google Scholar 

  • Altamura AC, Delvecchio G, Marotta G, Oldani L, Pigoni A, Ciappolino V, Caletti E, Rovera C, Dobrea C, Arici C, Benatti B, Camuri G, Prunas C, Paoli RA, Dell’osso B, Cinnante C, Triulzi FM, Brambilla P (2017) Structural and metabolic differentiation between bipolar disorder with psychosis and substance-induced psychosis: an integrated MRI/PET study. Eur Psychiatry 41:85–94. https://doi.org/10.1016/j.eurpsy.2016.09.009

    Article  CAS  PubMed  Google Scholar 

  • Ambrosi E, Chiapponi C, Sani G, Manfredi G, Piras F, Caltagirone C, Spalletta G (2016) White matter microstructural characteristics in bipolar I and bipolar II disorder: a diffusion tensor imaging study. J Affect Disord 189:176–183. https://doi.org/10.1016/j.jad.2015.09.035

    Article  PubMed  Google Scholar 

  • American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, 4th edn, text revision. American Psychiatric Association, Washington, DC

    Google Scholar 

  • Anand A, Barkay G, Dzemidzic M, Albrecht D, Karne H, Zheng QH, Hutchins GD, Normandin MD, Yoder KK (2011) Striatal dopamine transporter availability in unmedicated bipolar disorder. Bipolar Disord 13(4):406–413. https://doi.org/10.1111/j.1399-5618.2011.00936.x

    Article  PubMed  Google Scholar 

  • Anticevic A, Brumbaugh MS, Winkler AM, Lombardo LE, Barrett J, Corlett PR, Kober H, Gruber J, Repovs G, Cole MW, Krystal JH, Pearlson GD, Glahn DC (2013) Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biol Psychiatry 73(6):565–573. https://doi.org/10.1016/j.biopsych.2012.07.031

    Article  PubMed  Google Scholar 

  • Bauer IE, Sanches M, Suchting R, Green CE, El Fangary NM, Zunta-Soares GB, Soares JC (2014) Amygdala enlargement in unaffected offspring of bipolar parents. J Psychiatr Res 59:200–205. https://doi.org/10.1016/j.jpsychires.2014.08.023

    Article  PubMed  PubMed Central  Google Scholar 

  • Benedetti F, Yeh PH, Bellani M, Radaelli D, Nicoletti MA, Poletti S, Falini A, Dallaspezia S, Colombo C, Scotti G, Smeraldi E, Soares JC, Brambilla P (2011) Disruption of white matter integrity in bipolar depression as a possible structural marker of illness. Biol Psychiatry 69(4):309–317. https://doi.org/10.1016/j.biopsych.2010.07.028

    Article  PubMed  Google Scholar 

  • Berk M, Dodd S, Kauer-Sant’anna M, Malhi GS, Bourin M, Kapczinski F, Norman T (2007) Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder. Acta Psychiatr Scand Suppl 434:41–49. https://doi.org/10.1111/j.1600-0447.2007.01058.x

    Article  Google Scholar 

  • Boen E, Hjornevik T, Hummelen B, Elvsashagen T, Moberget T, Holtedahl JE, Babovic A, Hol PK, Karterud S, Malt UF (2019) Patterns of altered regional brain glucose metabolism in borderline personality disorder and bipolar II disorder. Acta Psychiatr Scand 139(3):256–268. https://doi.org/10.1111/acps.12997

    Article  CAS  PubMed  Google Scholar 

  • Bollettini I, Poletti S, Locatelli C, Vai B, Smeraldi E, Colombo C, Benedetti F (2015) Disruption of white matter integrity marks poor antidepressant response in bipolar disorder. J Affect Disord 174:233–240. https://doi.org/10.1016/j.jad.2014.11.010

    Article  CAS  PubMed  Google Scholar 

  • Bootsman F, Brouwer RM, Kemner SM, Schnack HG, van der Schot AC, Vonk R, Hillegers MH, Boomsma DI, Hulshoff Pol HE, Nolen WA, Kahn RS, van Haren NE (2015) Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder. Eur Neuropsychopharmacol 25(12):2197–2209. https://doi.org/10.1016/j.euroneuro.2015.09.023

    Article  CAS  PubMed  Google Scholar 

  • Brady RO Jr, Masters GA, Mathew IT, Margolis A, Cohen BM, Ongur D, Keshavan M (2016) State dependent cortico-amygdala circuit dysfunction in bipolar disorder. J Affect Disord 201:79–87. https://doi.org/10.1016/j.jad.2016.04.052

    Article  PubMed  PubMed Central  Google Scholar 

  • Brady RO Jr, Margolis A, Masters GA, Keshavan M, Ongur D (2017) Bipolar mood state reflected in cortico-amygdala resting state connectivity: a cohort and longitudinal study. J Affect Disord 217:205–209. https://doi.org/10.1016/j.jad.2017.03.043

    Article  PubMed  PubMed Central  Google Scholar 

  • Brambilla P, Bellani M, Yeh PH, Soares JC (2009) Myelination in bipolar patients and the effects of mood stabilizers on brain anatomy. Curr Pharm Des 15(22):2632–2636. https://doi.org/10.2174/138161209788957519

    Article  CAS  PubMed  Google Scholar 

  • Brooks JO 3rd, Wang PW, Bonner JC, Rosen AC, Hoblyn JC, Hill SJ, Ketter TA (2009) Decreased prefrontal, anterior cingulate, insula, and ventral striatal metabolism in medication-free depressed outpatients with bipolar disorder. J Psychiatr Res 43(3):181–188. https://doi.org/10.1016/j.jpsychires.2008.04.015

    Article  Google Scholar 

  • Cannon DM, Ichise M, Fromm SJ, Nugent AC, Rollis D, Gandhi SK, Klaver JM, Charney DS, Manji HK, Drevets WC (2006) Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography. Biol Psychiatry 60(3):207–217. https://doi.org/10.1016/j.biopsych.2006.05.005

    Article  CAS  PubMed  Google Scholar 

  • Caseras X, Murphy K, Lawrence NS, Fuentes-Claramonte P, Watts J, Jones DK, Phillips ML (2015) Emotion regulation deficits in euthymic bipolar I versus bipolar II disorder: a functional and diffusion-tensor imaging study. Bipolar Disord 17(5):461–470. https://doi.org/10.1111/bdi.12292

    Article  PubMed  PubMed Central  Google Scholar 

  • Cazala F, Suchting R, Zeni CP, Bauer IE, Mwangi B, Wu MJ, Passos IC, Spiker DE, Zunta-Soares GB, Soares JC (2018) Effects of valproate on brain volumes in pediatric bipolar disorder: a preliminary study. Psychiatry Res Neuroimaging 278:65–68. https://doi.org/10.1016/j.pscychresns.2018.05.006

    Article  PubMed  Google Scholar 

  • Chow MS, Wu SL, Webb SE, Gluskin K, Yew DT (2017) Functional magnetic resonance imaging and the brain: a brief review. World J Radiol 9(1):5–9. https://doi.org/10.4329/wjr.v9.i1.5

    Article  PubMed  PubMed Central  Google Scholar 

  • Dandash O, Yucel M, Daglas R, Pantelis C, McGorry P, Berk M, Fornito A (2018) Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania. Transl Psychiatry 8(1):59. https://doi.org/10.1038/s41398-018-0108-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • DelBello MP, Zimmerman ME, Mills NP, Getz GE, Strakowski SM (2004) Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disord 6(1):43–52. https://doi.org/10.1046/j.1399-5618.2003.00087.x

    Article  PubMed  Google Scholar 

  • Duarte JA, de Araujo ESJQ, Goldani AA, Massuda R, Gama CS (2016) Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review. Braz J Psychiatry 38(2):167–175. https://doi.org/10.1590/1516-4446-2015-1793

    Article  PubMed  PubMed Central  Google Scholar 

  • Ellard KK, Fairholme CP, Boisseau CL, Farchione TJ, Barlow DH (2010) Unified protocol for the transdiagnostic treatment of emotional disorders: protocol development and initial outcome data. Cogn Behav Pract 17(1):14

    Article  Google Scholar 

  • Ellard KK, Gosai AG, Bernstein EE, Kaur N, Sylvia LG, Camprodon JA, Dougherty DD, Nierenberg AA, Deckersbach T (2018) Intrinsic functional neurocircuitry associated with treatment response to transdiagnostic CBT in bipolar disorder with anxiety. J Affect Disord 238:383–391. https://doi.org/10.1016/j.jad.2018.06.002

    Article  PubMed  PubMed Central  Google Scholar 

  • Faustino PR, Duarte GS, Chendo I, Castro Caldas A, Reimao S, Fernandes RM, Vale J, Tinazzi M, Bhatia K, Ferreira JJ (2019) Risk of developing Parkinson disease in bipolar disorder: a systematic review and meta-analysis. JAMA Neurol 77(2):192–198. https://doi.org/10.1001/jamaneurol.2019.3446

    Article  Google Scholar 

  • Favre P, Pauling M, Stout J, Hozer F, Sarrazin S, Abe C, Alda M, Alloza C, Alonso-Lana S, Andreassen OA, Baune BT, Benedetti F, Busatto GF, Canales-Rodriguez EJ, Caseras X, Chaim-Avancini TM, Ching CRK, Dannlowski U, Deppe M, Eyler LT, Fatjo-Vilas M, Foley SF, Grotegerd D, Hajek T, Haukvik UK, Howells FM, Jahanshad N, Kugel H, Lagerberg TV, Lawrie SM, Linke JO, McIntosh A, Melloni EMT, Mitchell PB, Polosan M, Pomarol-Clotet E, Repple J, Roberts G, Roos A, Rosa PGP, Salvador R, Sarro S, Schofield PR, Serpa MH, Sim K, Stein DJ, Sussmann JE, Temmingh HS, Thompson PM, Verdolini N, Vieta E, Wessa M, Whalley HC, Zanetti MV, Leboyer M, Mangin JF, Henry C, Duchesnay E, Houenou J, Group EBDW (2019) Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals. Neuropsychopharmacology 44(13):2285–2293. https://doi.org/10.1038/s41386-019-0485-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Foley SF, Bracher-Smith M, Tansey KE, Harrison JR, Parker GD, Caseras X (2018) Fractional anisotropy of the uncinate fasciculus and cingulum in bipolar disorder type I, type II, unaffected siblings and healthy controls. Br J Psychiatry 213(3):548–554. https://doi.org/10.1192/bjp.2018.101

    Article  PubMed  PubMed Central  Google Scholar 

  • Frias A, Baltasar I, Birmaher B (2016) Comorbidity between bipolar disorder and borderline personality disorder: prevalence, explanatory theories, and clinical impact. J Affect Disord 202:210–219. https://doi.org/10.1016/j.jad.2016.05.048

    Article  PubMed  Google Scholar 

  • Gama CS, Kunz M, Magalhaes PV, Kapczinski F (2013) Staging and neuroprogression in bipolar disorder: a systematic review of the literature. Braz J Psychiatry 35(1):70–74

    Article  Google Scholar 

  • Ganzola R, Nickson T, Bastin ME, Giles S, Macdonald A, Sussmann J, McIntosh AM, Whalley HC, Duchesne S (2017) Longitudinal differences in white matter integrity in youth at high familial risk for bipolar disorder. Bipolar Disord 19(3):158–167. https://doi.org/10.1111/bdi.12489

    Article  PubMed  Google Scholar 

  • Godwin D, Alpert KI, Wang L, Mamah D (2018) Regional cortical thinning in young adults with schizophrenia but not psychotic or non-psychotic bipolar I disorder. Int J Bipolar Disord 6(1):16. https://doi.org/10.1186/s40345-018-0124-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gonul AS, Coburn K, Kula M (2009) Cerebral blood flow, metabolic, receptor, and transporter changes in bipolar disorder: the role of PET and SPECT studies. Int Rev Psychiatry 21(4):323–335. https://doi.org/10.1080/09540260902962131

    Article  PubMed  Google Scholar 

  • Goya-Maldonado R, Brodmann K, Keil M, Trost S, Dechent P, Gruber O (2016) Differentiating unipolar and bipolar depression by alterations in large-scale brain networks. Hum Brain Mapp 37(2):808–818. https://doi.org/10.1002/hbm.23070

    Article  PubMed  Google Scholar 

  • Haarman BC, Riemersma-Van der Lek RF, de Groot JC, Ruhe HG, Klein HC, Zandstra TE, Burger H, Schoevers RA, de Vries EF, Drexhage HA, Nolen WA, Doorduin J (2014) Neuroinflammation in bipolar disorder – a [(11)C]-(R)-PK11195 positron emission tomography study. Brain Behav Immun 40:219–225. https://doi.org/10.1016/j.bbi.2014.03.016

    Article  CAS  PubMed  Google Scholar 

  • Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62

    Article  CAS  Google Scholar 

  • Han KM, De Berardis D, Fornaro M, Kim YK (2019) Differentiating between bipolar and unipolar depression in functional and structural MRI studies. Prog Neuro-Psychopharmacol Biol Psychiatry 91:20–27. https://doi.org/10.1016/j.pnpbp.2018.03.022

    Article  Google Scholar 

  • Hanford LC, Nazarov A, Hall GB, Sassi RB (2016) Cortical thickness in bipolar disorder: a systematic review. Bipolar Disord 18(1):4–18. https://doi.org/10.1111/bdi.12362

    Article  PubMed  Google Scholar 

  • Hibar DP, Westlye LT, van Erp TG, Rasmussen J, Leonardo CD, Faskowitz J, Haukvik UK, Hartberg CB, Doan NT, Agartz I, Dale AM, Gruber O, Kramer B, Trost S, Liberg B, Abe C, Ekman CJ, Ingvar M, Landen M, Fears SC, Freimer NB, Bearden CE, Sprooten E, Glahn DC, Pearlson GD, Emsell L, Kenney J, Scanlon C, McDonald C, Cannon DM, Almeida J, Versace A, Caseras X, Lawrence NS, Phillips ML, Dima D, Delvecchio G, Frangou S, Satterthwaite TD, Wolf D, Houenou J, Henry C, Malt UF, Boen E, Elvsashagen T, Young AH, Lloyd AJ, Goodwin GM, Mackay CE, Bourne C, Bilderbeck A, Abramovic L, Boks MP, van Haren NE, Ophoff RA, Kahn RS, Bauer M, Pfennig A, Alda M, Hajek T, Mwangi B, Soares JC, Nickson T, Dimitrova R, Sussmann JE, Hagenaars S, Whalley HC, McIntosh AM, Thompson PM, Andreassen OA, Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar E (2016) Subcortical volumetric abnormalities in bipolar disorder. Mol Psychiatry 21(12):1710–1716. https://doi.org/10.1038/mp.2015.227

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hibar DP, Westlye LT, Doan NT, Jahanshad N, Cheung JW, Ching CRK, Versace A, Bilderbeck AC, Uhlmann A, Mwangi B, Kramer B, Overs B, Hartberg CB, Abe C, Dima D, Grotegerd D, Sprooten E, Boen E, Jimenez E, Howells FM, Delvecchio G, Temmingh H, Starke J, Almeida JRC, Goikolea JM, Houenou J, Beard LM, Rauer L, Abramovic L, Bonnin M, Ponteduro MF, Keil M, Rive MM, Yao N, Yalin N, Najt P, Rosa PG, Redlich R, Trost S, Hagenaars S, Fears SC, Alonso-Lana S, van Erp TGM, Nickson T, Chaim-Avancini TM, Meier TB, Elvsashagen T, Haukvik UK, Lee WH, Schene AH, Lloyd AJ, Young AH, Nugent A, Dale AM, Pfennig A, McIntosh AM, Lafer B, Baune BT, Ekman CJ, Zarate CA, Bearden CE, Henry C, Simhandl C, McDonald C, Bourne C, Stein DJ, Wolf DH, Cannon DM, Glahn DC, Veltman DJ, Pomarol-Clotet E, Vieta E, Canales-Rodriguez EJ, Nery FG, Duran FLS, Busatto GF, Roberts G, Pearlson GD, Goodwin GM, Kugel H, Whalley HC, Ruhe HG, Soares JC, Fullerton JM, Rybakowski JK, Savitz J, Chaim KT, Fatjo-Vilas M, Soeiro-de-Souza MG, Boks MP, Zanetti MV, Otaduy MCG, Schaufelberger MS, Alda M, Ingvar M, Phillips ML, Kempton MJ, Bauer M, Landen M, Lawrence NS, van Haren NEM, Horn NR, Freimer NB, Gruber O, Schofield PR, Mitchell PB, Kahn RS, Lenroot R, Machado-Vieira R, Ophoff RA, Sarro S, Frangou S, Satterthwaite TD, Hajek T, Dannlowski U, Malt UF, Arolt V, Gattaz WF, Drevets WC, Caseras X, Agartz I, Thompson PM, Andreassen OA (2018) Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Mol Psychiatry 23(4):932–942. https://doi.org/10.1038/mp.2017.73

    Article  CAS  PubMed  Google Scholar 

  • Ho NF, Li Hui Chong P, Lee DR, Chew QH, Chen G, Sim K (2019) The amygdala in schizophrenia and bipolar disorder: a synthesis of structural MRI, diffusion tensor imaging, and resting-state functional connectivity findings. Harv Rev Psychiatry 27(3):150–164. https://doi.org/10.1097/HRP.0000000000000207

    Article  PubMed  Google Scholar 

  • Hosokawa T, Momose T, Kasai K (2009) Brain glucose metabolism difference between bipolar and unipolar mood disorders in depressed and euthymic states. Prog Neuro-Psychopharmacol Biol Psychiatry 33(2):243–250. https://doi.org/10.1016/j.pnpbp.2008.11.014

    Article  CAS  Google Scholar 

  • Ives-Deliperi VL, Howells F, Stein DJ, Meintjes EM, Horn N (2013) The effects of mindfulness-based cognitive therapy in patients with bipolar disorder: a controlled functional MRI investigation. J Affect Disord 150(3):1152–1157. https://doi.org/10.1016/j.jad.2013.05.074

    Article  PubMed  Google Scholar 

  • Jauhar S, Nour MM, Veronese M, Rogdaki M, Bonoldi I, Azis M, Turkheimer F, McGuire P, Young AH, Howes OD (2017) A test of the transdiagnostic dopamine hypothesis of psychosis using positron emission tomographic imaging in bipolar affective disorder and schizophrenia. JAMA Psychiat 74(12):1206–1213. https://doi.org/10.1001/jamapsychiatry.2017.2943

    Article  Google Scholar 

  • Johnstone EC, Owens DG, Crow TJ, Frith CD, Alexandropolis K, Bydder G, Colter N (1989) Temporal lobe structure as determined by nuclear magnetic resonance in schizophrenia and bipolar affective disorder. J Neurol Neurosurg Psychiatry 52(6):736–741. https://doi.org/10.1136/jnnp.52.6.736

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kafantaris V, Spritzer L, Doshi V, Saito E, Szeszko PR (2017) Changes in white matter microstructure predict lithium response in adolescents with bipolar disorder. Bipolar Disord 19(7):587–594. https://doi.org/10.1111/bdi.12544

    Article  CAS  PubMed  Google Scholar 

  • Kalia LV, Lang AE (2015) Parkinson’s disease. Lancet 386(9996):896–912. https://doi.org/10.1016/S0140-6736(14)61393-3. [pii] S0140-6736(14)61393-3

    Article  CAS  PubMed  Google Scholar 

  • Karcher NR, Rogers BP, Woodward ND (2019) Functional connectivity of the striatum in schizophrenia and psychotic bipolar disorder. Biol Psychiatry Cogn Neurosci Neuroimaging 4(11):956–965. https://doi.org/10.1016/j.bpsc.2019.05.017

    Article  PubMed  PubMed Central  Google Scholar 

  • Langenecker SA, Jacobs RH, Passarotti AM (2014) Current neural and behavioral dimensional constructs across mood disorders. Curr Behav Neurosci Rep 1(3):144–153. https://doi.org/10.1007/s40473-014-0018-x

    Article  PubMed  PubMed Central  Google Scholar 

  • Li J, Kale Edmiston E, Chen K, Tang Y, Ouyang X, Jiang Y, Fan G, Ren L, Liu J, Zhou Y, Jiang W, Liu Z, Xu K, Wang F (2014) A comparative diffusion tensor imaging study of corpus callosum subregion integrity in bipolar disorder and schizophrenia. Psychiatry Res 221(1):58–62. https://doi.org/10.1016/j.pscychresns.2013.10.007

    Article  PubMed  Google Scholar 

  • Li M, Das T, Deng W, Wang Q, Li Y, Zhao L, Ma X, Wang Y, Yu H, Li X, Meng Y, Palaniyappan L, Li T (2017) Clinical utility of a short resting-state MRI scan in differentiating bipolar from unipolar depression. Acta Psychiatr Scand 136(3):288–299. https://doi.org/10.1111/acps.12752

    Article  CAS  PubMed  Google Scholar 

  • Li L, Ji E, Han X, Tang F, Bai Y, Peng D, Fang Y, Zhang S, Zhang Z, Yang H (2019) Cortical thickness and subcortical volumes alterations in euthymic bipolar I patients treated with different mood stabilizers. Brain Imaging Behav 13(5):1255–1264. https://doi.org/10.1007/s11682-018-9950-9

    Article  PubMed  Google Scholar 

  • Librenza-Garcia D, Kotzian BJ, Yang J, Mwangi B, Cao B, Pereira Lima LN, Bermudez MB, Boeira MV, Kapczinski F, Passos IC (2017) The impact of machine learning techniques in the study of bipolar disorder: a systematic review. Neurosci Biobehav Rev 80:538–554. https://doi.org/10.1016/j.neubiorev.2017.07.004

    Article  PubMed  Google Scholar 

  • Liu JX, Chen YS, Hsieh JC, Su TP, Yeh TC, Chen LF (2010) Differences in white matter abnormalities between bipolar I and II disorders. J Affect Disord 127(1–3):309–315. https://doi.org/10.1016/j.jad.2010.05.026

    Article  PubMed  Google Scholar 

  • Liu CH, Ma X, Li F, Wang YJ, Tie CL, Li SF, Chen TL, Fan TT, Zhang Y, Dong J, Yao L, Wu X, Wang CY (2012) Regional homogeneity within the default mode network in bipolar depression: a resting-state functional magnetic resonance imaging study. PLoS One 7(11):e48181. https://doi.org/10.1371/journal.pone.0048181

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lovas DA, Schuman-Olivier Z (2018) Mindfulness-based cognitive therapy for bipolar disorder: a systematic review. J Affect Disord 240:247–261. https://doi.org/10.1016/j.jad.2018.06.017

    Article  PubMed  PubMed Central  Google Scholar 

  • Ma Q, Tang Y, Wang F, Liao X, Jiang X, Wei S, Mechelli A, He Y, Xia M (2019) Transdiagnostic dysfunctions in brain modules across patients with schizophrenia, bipolar disorder, and major depressive disorder: a connectome-based study. Schizophr Bull 46(3):699–712. https://doi.org/10.1093/schbul/sbz111

    Article  Google Scholar 

  • Mah L, Zarate CA Jr, Singh J, Duan YF, Luckenbaugh DA, Manji HK, Drevets WC (2007) Regional cerebral glucose metabolic abnormalities in bipolar II depression. Biol Psychiatry 61(6):765–775. https://doi.org/10.1016/j.biopsych.2006.06.009

    Article  CAS  PubMed  Google Scholar 

  • Mahapatra A, Khandelwal SK, Sharan P, Garg A, Mishra NK (2017) Diffusion tensor imaging tractography study in bipolar disorder patients compared to first-degree relatives and healthy controls. Psychiatry Clin Neurosci 71(10):706–715. https://doi.org/10.1111/pcn.12530

    Article  PubMed  Google Scholar 

  • Mak LE, Minuzzi L, MacQueen G, Hall G, Kennedy SH, Milev R (2017) The default mode network in healthy individuals: a systematic review and meta-analysis. Brain Connect 7(1):25–33. https://doi.org/10.1089/brain.2016.0438

    Article  PubMed  Google Scholar 

  • Marotta G, Delvecchio G, Pigoni A, Mandolini G, Ciappolino V, Oldani L, Madonna D, Grottaroli M, Altamura AC, Brambilla P (2019) The metabolic basis of psychosis in bipolar disorder: a positron emission tomography study. Bipolar Disord 21(2):151–158. https://doi.org/10.1111/bdi.12710

    Article  PubMed  Google Scholar 

  • Matsuo K, Harada K, Fujita Y, Okamoto Y, Ota M, Narita H, Mwangi B, Gutierrez CA, Okada G, Takamura M, Yamagata H, Kusumi I, Kunugi H, Inoue T, Soares JC, Yamawaki S, Watanabe Y (2019) Distinctive neuroanatomical substrates for depression in bipolar disorder versus major depressive disorder. Cereb Cortex 29(1):202–214. https://doi.org/10.1093/cercor/bhx319

    Article  PubMed  Google Scholar 

  • McGrath BM, Wessels PH, Bell EC, Ulrich M, Silverstone PH (2004) Neurobiological findings in bipolar II disorder compared with findings in bipolar I disorder. Can J Psychiatry 49(12):794–801. https://doi.org/10.1177/070674370404901202

    Article  PubMed  Google Scholar 

  • Mwangi B, Wu MJ, Bauer IE, Modi H, Zeni CP, Zunta-Soares GB, Hasan KM, Soares JC (2015) Predictive classification of pediatric bipolar disorder using atlas-based diffusion weighted imaging and support vector machines. Psychiatry Res 234(2):265–271. https://doi.org/10.1016/j.pscychresns.2015.10.002

    Article  PubMed  PubMed Central  Google Scholar 

  • Najt P, Wang F, Spencer L, Johnston JA, Cox Lippard ET, Pittman BP, Lacadie C, Staib LH, Papademetris X, Blumberg HP (2016) Anterior cortical development during adolescence in bipolar disorder. Biol Psychiatry 79(4):303–310. https://doi.org/10.1016/j.biopsych.2015.03.026

    Article  PubMed  Google Scholar 

  • National Institute of Mental Health (2008) Research domain criteria (RDoC). http://www.nimh.nih.gov/research-priorities/rdoc/index.shtml. Accessed 26 Oct 2013

  • Nugent AC, Diazgranados N, Carlson PJ, Ibrahim L, Luckenbaugh DA, Brutsche N, Herscovitch P, Drevets WC, Zarate CA Jr (2014) Neural correlates of rapid antidepressant response to ketamine in bipolar disorder. Bipolar Disord 16(2):119–128. https://doi.org/10.1111/bdi.12118

    Article  CAS  PubMed  Google Scholar 

  • Nunes A, Schnack HG, Ching CRK, Agartz I, Akudjedu TN, Alda M, Alnaes D, Alonso-Lana S, Bauer J, Baune BT, Boen E, Bonnin CDM, Busatto GF, Canales-Rodriguez EJ, Cannon DM, Caseras X, Chaim-Avancini TM, Dannlowski U, Diaz-Zuluaga AM, Dietsche B, Doan NT, Duchesnay E, Elvsashagen T, Emden D, Eyler LT, Fatjo-Vilas M, Favre P, Foley SF, Fullerton JM, Glahn DC, Goikolea JM, Grotegerd D, Hahn T, Henry C, Hibar DP, Houenou J, Howells FM, Jahanshad N, Kaufmann T, Kenney J, Kircher TTJ, Krug A, Lagerberg TV, Lenroot RK, Lopez-Jaramillo C, Machado-Vieira R, Malt UF, McDonald C, Mitchell PB, Mwangi B, Nabulsi L, Opel N, Overs BJ, Pineda-Zapata JA, Pomarol-Clotet E, Redlich R, Roberts G, Rosa PG, Salvador R, Satterthwaite TD, Soares JC, Stein DJ, Temmingh HS, Trappenberg T, Uhlmann A, van Haren NEM, Vieta E, Westlye LT, Wolf DH, Yuksel D, Zanetti MV, Andreassen OA, Thompson PM, Hajek T, Group EBDW (2018) Using structural MRI to identify bipolar disorders – 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group. Mol Psychiatry. https://doi.org/10.1038/s41380-018-0228-9

  • Parikh SV, Quilty LC, Ravitz P, Rosenbluth M, Pavlova B, Grigoriadis S, Velyvis V, Kennedy SH, Lam RW, MacQueen GM, Milev RV, Ravindran AV, Uher R, Group CDW (2016) Canadian network for mood and anxiety treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 2. Psychological treatments. Can J Psychiatry 61(9):524–539. https://doi.org/10.1177/0706743716659418

    Article  PubMed  PubMed Central  Google Scholar 

  • Passos IC, Ballester PL, Barros RC, Librenza-Garcia D, Mwangi B, Birmaher B, Brietzke E, Hajek T, Lopez Jaramillo C, Mansur RB, Alda M, Haarman BCM, Isometsa E, Lam RW, McIntyre RS, Minuzzi L, Kessing LV, Yatham LN, Duffy A, Kapczinski F (2019) Machine learning and big data analytics in bipolar disorder: a position paper from the International Society for Bipolar Disorders Big Data Task Force. Bipolar Disord 21(7):582–594. https://doi.org/10.1111/bdi.12828

    Article  PubMed  Google Scholar 

  • Phillips ML, Swartz HA (2014) A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research. Am J Psychiatry 171(8):829–843. https://doi.org/10.1176/appi.ajp.2014.13081008

    Article  PubMed  PubMed Central  Google Scholar 

  • Reisberg B (1988) Functional assessment staging (FAST). Psychopharmacol Bull 24(4):653–659

    CAS  PubMed  Google Scholar 

  • Rubin-Falcone H, Zanderigo F, Thapa-Chhetry B, Lan M, Miller JM, Sublette ME, Oquendo MA, Hellerstein DJ, McGrath PJ, Stewart JW, Mann JJ (2018) Pattern recognition of magnetic resonance imaging-based gray matter volume measurements classifies bipolar disorder and major depressive disorder. J Affect Disord 227:498–505. https://doi.org/10.1016/j.jad.2017.11.043

    Article  PubMed  Google Scholar 

  • Sanches M, Roberts RL, Sassi RB, Axelson D, Nicoletti M, Brambilla P, Hatch JP, Keshavan MS, Ryan ND, Birmaher B, Soares JC (2005) Developmental abnormalities in striatum in young bipolar patients: a preliminary study. Bipolar Disord 7(2):153–158. https://doi.org/10.1111/j.1399-5618.2004.00178.x

    Article  PubMed  Google Scholar 

  • Sanches M, Amorim E, Mwangi B, Zunta-Soares GB, Soares JC (2019) Smaller left anterior cingulate cortex in non-bipolar relatives of patients with bipolar disorder. Braz J Psychiatry 41(3):254–256. https://doi.org/10.1590/1516-4446-2018-0051

    Article  PubMed  Google Scholar 

  • Sani G, Simonetti A, Janiri D, Banaj N, Ambrosi E, De Rossi P, Ciullo V, Arciniegas DB, Piras F, Spalletta G (2018) Association between duration of lithium exposure and hippocampus/amygdala volumes in type I bipolar disorder. J Affect Disord 232:341–348. https://doi.org/10.1016/j.jad.2018.02.042

    Article  CAS  PubMed  Google Scholar 

  • Sartori JM, Reckziegel R, Passos IC, Czepielewski LS, Fijtman A, Sodre LA, Massuda R, Goi PD, Vianna-Sulzbach M, Cardoso TA, Kapczinski F, Mwangi B, Gama CS (2018) Volumetric brain magnetic resonance imaging predicts functioning in bipolar disorder: a machine learning approach. J Psychiatr Res 103:237–243. https://doi.org/10.1016/j.jpsychires.2018.05.023

    Article  PubMed  Google Scholar 

  • Scott J, Hidalgo-Mazzei D, Strawbridge R, Young A, Resche-Rigon M, Etain B, Andreassen OA, Bauer M, Bennabi D, Blamire AM, Boumezbeur F, Brambilla P, Cattane N, Cattaneo A, Chupin M, Coello K, Cointepas Y, Colom F, Cousins DA, Dubertret C, Duchesnay E, Ferro A, Garcia-Estela A, Goikolea J, Grigis A, Haffen E, Hoegh MC, Jakobsen P, Kalman JL, Kessing LV, Klohn-Saghatolislam F, Lagerberg TV, Landen M, Lewitzka U, Lutticke A, Mazer N, Mazzelli M, Mora C, Muller T, Mur-Mila E, Oedegaard KJ, Oltedal L, Palsson E, Papadopoulos Orfanos D, Papiol S, Perez-Sola V, Reif A, Ritter P, Rossi R, Schulze T, Senner F, Smith FE, Squarcina L, Steen NE, Thelwall PE, Varo C, Vieta E, Vinberg M, Wessa M, Westlye LT, Bellivier F (2019) Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. Int J Bipolar Disord 7(1):20. https://doi.org/10.1186/s40345-019-0156-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sexton CE, Allan CL, Mackay CE, Ebmeier KP (2012) White matter integrity within the corpus callosum differentiates late-life bipolar and unipolar depression. Bipolar Disord 14(7):790–791. https://doi.org/10.1111/j.1399-5618.2012.01050.x

    Article  PubMed  Google Scholar 

  • Shorter E (1997) A history of psychiatry: from the era of the asylum to the age of Prozac. Wiley, Lexington

    Google Scholar 

  • Singh MK, Chang KD, Kelley RG, Saggar M, Reiss AL, Gotlib IH (2014) Early signs of anomalous neural functional connectivity in healthy offspring of parents with bipolar disorder. Bipolar Disord 16(7):678–689. https://doi.org/10.1111/bdi.12221

    Article  PubMed  PubMed Central  Google Scholar 

  • Skudlarski P, Schretlen DJ, Thaker GK, Stevens MC, Keshavan MS, Sweeney JA, Tamminga CA, Clementz BA, O’Neil K, Pearlson GD (2013) Diffusion tensor imaging white matter endophenotypes in patients with schizophrenia or psychotic bipolar disorder and their relatives. Am J Psychiatry 170(8):886–898. https://doi.org/10.1176/appi.ajp.2013.12111448

    Article  PubMed  Google Scholar 

  • Soares JC, Mann JJ (1997) The anatomy of mood disorders--review of structural neuroimaging studies. Biol Psychiatry 41(1):86–106. https://doi.org/10.1016/s0006-3223(96)00006-6

    Article  CAS  PubMed  Google Scholar 

  • Spielberg JM, Matyi MA, Karne H, Anand A (2019) Lithium monotherapy associated longitudinal effects on resting state brain networks in clinical treatment of bipolar disorder. Bipolar Disord 21(4):361–371. https://doi.org/10.1111/bdi.12718

    Article  CAS  PubMed  Google Scholar 

  • Steinberg EE, Christoffel DJ, Deisseroth K, Malenka RC (2015) Illuminating circuitry relevant to psychiatric disorders with optogenetics. Curr Opin Neurobiol 30:9–16. https://doi.org/10.1016/j.conb.2014.08.004

    Article  CAS  PubMed  Google Scholar 

  • Sugranyes G, Sole-Padulles C, de la Serna E, Borras R, Romero S, Sanchez-Gistau V, Garcia-Rizo C, Goikolea JM, Bargallo N, Moreno D, Baeza I, Castro-Fornieles J (2017) Cortical morphology characteristics of young offspring of patients with schizophrenia or bipolar disorder. J Am Acad Child Adolesc Psychiatry 56(1):79–88. https://doi.org/10.1016/j.jaac.2016.09.516

    Article  PubMed  Google Scholar 

  • Teasdale JD, Segal ZV, Williams JM, Ridgeway VA, Soulsby JM, Lau MA (2000) Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. J Consult Clin Psychol 68(4):615–623. https://doi.org/10.1037//0022-006x.68.4.615

    Article  CAS  PubMed  Google Scholar 

  • Tonnesen S, Kaufmann T, Doan NT, Alnaes D, Cordova-Palomera A, Meer DV, Rokicki J, Moberget T, Gurholt TP, Haukvik UK, Ueland T, Lagerberg TV, Agartz I, Andreassen OA, Westlye LT (2018) White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging. Sci Rep 8(1):14129. https://doi.org/10.1038/s41598-018-32355-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • van den Heuvel MP, Hulshoff Pol HE (2010) Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol 20(8):519–534. https://doi.org/10.1016/j.euroneuro.2010.03.008

    Article  CAS  PubMed  Google Scholar 

  • Vargas C, Lopez-Jaramillo C, Vieta E (2013) A systematic literature review of resting state network--functional MRI in bipolar disorder. J Affect Disord 150(3):727–735. https://doi.org/10.1016/j.jad.2013.05.083

    Article  PubMed  Google Scholar 

  • Vizueta N, Rudie JD, Townsend JD, Torrisi S, Moody TD, Bookheimer SY, Altshuler LL (2012) Regional fMRI hypoactivation and altered functional connectivity during emotion processing in nonmedicated depressed patients with bipolar II disorder. Am J Psychiatry 169(8):831–840. https://doi.org/10.1176/appi.ajp.2012.11030349

    Article  PubMed  PubMed Central  Google Scholar 

  • Weathers J, Lippard ETC, Spencer L, Pittman B, Wang F, Blumberg HP (2018) Longitudinal diffusion tensor imaging study of adolescents and young adults with bipolar disorder. J Am Acad Child Adolesc Psychiatry 57(2):111–117. https://doi.org/10.1016/j.jaac.2017.11.014

    Article  PubMed  Google Scholar 

  • Wu MJ, Mwangi B, Bauer IE, Passos IC, Sanches M, Zunta-Soares GB, Meyer TD, Hasan KM, Soares JC (2017) Identification and individualized prediction of clinical phenotypes in bipolar disorders using neurocognitive data, neuroimaging scans and machine learning. NeuroImage 145(Pt B):254–264. https://doi.org/10.1016/j.neuroimage.2016.02.016

    Article  PubMed  Google Scholar 

  • Yatham LN, Liddle PF, Lam RW, Adam MJ, Solomons K, Chinnapalli M, Ruth TJ (2005) A positron emission tomography study of the effects of treatment with valproate on brain 5-HT2A receptors in acute mania. Bipolar Disord 7(Suppl 5):53–57. https://doi.org/10.1111/j.1399-5618.2005.00252.x

    Article  CAS  PubMed  Google Scholar 

  • Zak N, Boen E, Boye B, Andreassen OA, Doan NT, Malt UF, Westlye LT, Elvsashagen T (2019) Mood episodes are associated with increased cortical thinning: a longitudinal study of bipolar disorder type II. Bipolar Disord 21(6):525–538. https://doi.org/10.1111/bdi.12771

    Article  PubMed  Google Scholar 

  • Zhang W, Xiao Y, Sun H, Patino LR, Tallman MJ, Weber WA, Adler CM, Klein C, Strawn JR, Nery FG, Gong Q, Sweeney JA, Lui S, DelBello MP (2018) Discrete patterns of cortical thickness in youth with bipolar disorder differentially predict treatment response to quetiapine but not lithium. Neuropsychopharmacology 43(11):2256–2263. https://doi.org/10.1038/s41386-018-0120-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA

    Alexandre Paim Diaz, Isabelle E. Bauer, Marsal Sanches & Jair C. Soares

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    Allan H. Young

  2. PO72 De Crespigny Park, King’s College London, London, UK

    Mario F. Juruena

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Diaz, A.P., Bauer, I.E., Sanches, M., Soares, J.C. (2020). Neuroanatomic and Functional Neuroimaging Findings. In: Young, A.H., Juruena, M.F. (eds) Bipolar Disorder: From Neuroscience to Treatment. Current Topics in Behavioral Neurosciences, vol 48. Springer, Cham. https://doi.org/10.1007/7854_2020_174

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