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Childhood Maltreatment in Bipolar Disorders

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Bipolar Disorder: From Neuroscience to Treatment

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 48))

Abstract

In this chapter, we will focus on childhood maltreatment and its role in the vulnerability to BD.

We will review how childhood maltreatment and trauma not only predispose to the development of BD but also to a more unstable, pernicious, and severe clinical expression of the disorder. This environmental risk factor is suggested to be part of a multiple hit model of vulnerability, involving not only early stressors (prenatal and postnatal ones) but also interactions with the genetic background of individuals and with other stressors occurring later in life. We will also review how childhood maltreatment and trauma may modify the brain functioning and circuits and alter some biological pathways in BD, hence leading to psychopathology. Finally, we will briefly discuss the implications for clinical practice and treatment.

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Authors and Affiliations

  1. Université de Paris, Paris, France

    Bruno Etain

  2. INSERM U1144, Faculté de Pharmacie de Paris, Université de Paris, Paris, France

    Bruno Etain

  3. Assistance Publique des Hôpitaux de Paris P-HP, GHU Saint-Louis – Lariboisière – F. Widal, Département de Psychiatrie et de Médecine Addictologique, Paris, France

    Bruno Etain

  4. NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway

    Monica Aas

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  1. Bruno Etain
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  2. Monica Aas
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Correspondence to Bruno Etain .

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  1. PO72 De Crespigny Park, King’s College London, London, UK

    Allan H. Young

  2. PO72 De Crespigny Park, King’s College London, London, UK

    Mario F. Juruena

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Etain, B., Aas, M. (2020). Childhood Maltreatment in Bipolar Disorders. In: Young, A.H., Juruena, M.F. (eds) Bipolar Disorder: From Neuroscience to Treatment. Current Topics in Behavioral Neurosciences, vol 48. Springer, Cham. https://doi.org/10.1007/7854_2020_149

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