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Autoantibodies and Psychosis

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Neuroinflammation and Schizophrenia

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 44))

Abstract

Research into antibody-mediated disease, in response to immune dysfunction or to tumour development, has rapidly expanded in recent years. Antibodies binding to neuroreceptors can cause psychiatric features, including psychosis, in a minority of patients as well as neurological features. The responsiveness of some of these cases to immunotherapy supports the hypothesis that antibody-associated mechanisms play a role in the pathogenesis of psychotic diseases. The purpose of this chapter is to review autoantibodies that are most likely to be relevant for patients with psychotic symptoms. Herein, we describe receptor structure and mechanism of action, clinical and psychiatric features for the growing number of neuronal surface antibodies, including those to the N-methyl-D-aspartate (NMDA) receptor. The identification of a subgroup of patients with psychiatric features having antibody-mediated disease highlights the importance of considering the diagnosis, particularly in those patients presenting with a first episode of psychosis.

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Authors and Affiliations

  1. Department of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland

    Eric Kelleher

  2. Department of Psychiatry, Royal College of Surgeons of Ireland, Dublin, Ireland

    Helen Barry, David R. Cotter & Kieran C. Murphy

  3. Department of Psychiatry, Trinity College Dublin, Dublin, Ireland

    Aiden Corvin

Authors
  1. Eric Kelleher
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  2. Helen Barry
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  3. David R. Cotter
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  4. Aiden Corvin
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  5. Kieran C. Murphy
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Corresponding author

Correspondence to Eric Kelleher .

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Editors and Affiliations

  1. Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK

    Golam M. Khandaker

  2. Verhaltensneurobiologie, ETH Zürich, Schwerzenbach, Switzerland

    Urs Meyer

  3. Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK

    Peter B. Jones

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Kelleher, E., Barry, H., Cotter, D.R., Corvin, A., Murphy, K.C. (2019). Autoantibodies and Psychosis. In: Khandaker, G., Meyer, U., Jones, P. (eds) Neuroinflammation and Schizophrenia. Current Topics in Behavioral Neurosciences, vol 44. Springer, Cham. https://doi.org/10.1007/7854_2019_90

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