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Hypothalamic Integration of the Endocrine Signaling Related to Food Intake

  • Anica Klockars
  • Allen S. Levine
  • Pawel K. Olszewski
Chapter
Part of the Current Topics in Behavioral Neurosciences book series

Abstract

Hypothalamic integration of gastrointestinal and adipose tissue-derived hormones serves as a key element of neuroendocrine control of food intake. Leptin, adiponectin, oleoylethanolamide, cholecystokinin, and ghrelin, to name a few, are in a constant “cross talk” with the feeding-related brain circuits that encompass hypothalamic populations synthesizing anorexigens (melanocortins, CART, oxytocin) and orexigens (Agouti-related protein, neuropeptide Y, orexins). While this integrated neuroendocrine circuit successfully ensures that enough energy is acquired, it does not seem to be equally efficient in preventing excessive energy intake, especially in the obesogenic environment in which highly caloric and palatable food is constantly available. The current review presents an overview of intricate mechanisms underlying hypothalamic integration of energy balance-related peripheral endocrine input. We discuss vulnerabilities and maladaptive neuroregulatory processes, including changes in hypothalamic neuronal plasticity that propel overeating despite negative consequences.

Keywords

Brain Hunger Hypothalamus Obesity Plasticity Satiety 

Notes

Acknowledgments

This work has been supported by the Royal Society of New Zealand and Dairy Goat Coop. (NZ), Ltd., Hamilton, New Zealand. The authors would like to thank Erin Wood for her help in preparing the figures.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Anica Klockars
    • 1
  • Allen S. Levine
    • 2
  • Pawel K. Olszewski
    • 1
    • 2
  1. 1.Department of Biological SciencesUniversity of WaikatoHamiltonNew Zealand
  2. 2.Department of Food Science and NutritionUniversity of MinnesotaSaint PaulUSA

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