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Depression in Autoimmune Diseases

Part of the Current Topics in Behavioral Neurosciences book series (CTBN,volume 31)

Abstract

Up to 50% of patients with autoimmune diseases show an impairment of health-related quality of life and exhibit depression-like symptoms. The immune system not only leads to inflammation in affected organs, but also mediates behavior abnormalities including fatigue and depression-like symptoms. This review focuses on the different pathways involved in the communication of the immune system with the neuronal network and the body’s timing system. The latter is built up by a hierarchically organized expression of clock genes. As discussed here, the activation of the immune system interferes with high amplitude expression of clock genes, an effect which may play a pivotal role in depression-like behavior in autoimmune diseases.

Keywords

  • Hepatitis
  • Indoleamine-2,3-dioxygenase
  • Interleukin-1
  • Kynurenine
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Tumor necrosis factor
  • Twist1

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References

  1. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctot KL (2010) A meta-analysis of cytokines in major depression. Biol Psychiatry 67:446–457

    CAS  CrossRef  PubMed  Google Scholar 

  2. Felger JC, Lotrich FE (2013) Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 246:199–229

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  3. Miller AH, Maletic V, Raison CL (2009) Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 65:732–741

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  4. Shelton RC, Claiborne J, Sidoryk-Wegrzynowicz M, Reddy R, Aschner M, Lewis DA, Mirnics K (2011) Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Mol Psychiatry 16:751–762

    CAS  CrossRef  PubMed  Google Scholar 

  5. Raison CL, Rutherford RE, Woolwine BJ, Shuo C, Schettler P, Drake DF, Haroon E, Miller AH (2013) A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 70:31–41

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  6. Fu X, Zunich SM, O’Connor JC, Kavelaars A, Dantzer R, Kelley KW (2010) Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures. J Neuroinflammation 7(43):1–12

    Google Scholar 

  7. Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46–57

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  8. Haroon E, Raison CL, Miller AH (2012) Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 37:137–162

    CAS  CrossRef  PubMed  Google Scholar 

  9. Greenley RN, Hommel KA, Nebel J, Raboin T, Li S-H, Simpson P, Mackner L (2010) A meta-analytic review of the psychosocial adjustment of youth with inflammatory bowel disease. J Pediatr Psychol 35:857–869

    CrossRef  PubMed  PubMed Central  Google Scholar 

  10. Marrie RA, Reider N, Cohen JY, Stuve O, Sorensen PS, Cutter G, Reingold SC, Trojano M (2015) A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis. Mult Scler J 21:282–293

    CrossRef  Google Scholar 

  11. Makay B, Emiroglu N, Ünsal E (2010) Depression and anxiety in children and adolescents with familial Mediterranean fever. Clin Rheumatol 29:375–379

    CrossRef  PubMed  Google Scholar 

  12. Palagini L, Mosca M, Tani C, Gemignani A, Mauri M, Bombardieri S (2013) Depression and systemic lupus erythematosus: a systematic review. Lupus 22:409–416

    CAS  CrossRef  PubMed  Google Scholar 

  13. Shen B, Feng G, Tang W, Huang X, Yan H, He Y, Chen W, Da Z, Liu H, Gu Z (2014) The quality of life in Chinese patients with systemic lupus erythematosus is associated with disease activity and psychiatric disorders: a path analysis. Clin Exp Rheumatol 32:101–107

    PubMed  Google Scholar 

  14. Pettersson S, Lövgren M, Eriksson LE, Moberg C, Svenungsson E, Gunnarsson I, Welin Henriksson E (2012) An exploration of patient-reported symptoms in systemic lupus erythematosus and the relationship to health-related quality of life. Scand J Rheumatol 41:383–390

    CAS  CrossRef  PubMed  Google Scholar 

  15. Waldheim E, Elkan A-C, Pettersson S, van Vollenhoven R, Bergman S, Frostegard J, Welin Henriksson E (2013) Health-related quality of life, fatigue and mood in patients with SLE and high levels of pain compared to controls and patients with low levels of pain. Lupus 22:1118–1127

    CAS  CrossRef  PubMed  Google Scholar 

  16. van Exel E, Jacobs J, Korswagen L-A, Voskuyl AE, Stek M, Dekker J, Bultink IEM (2013) Depression in systemic lupus erythematosus, dependent on or independent of severity of disease. Lupus 22:1462–1469

    CrossRef  PubMed  Google Scholar 

  17. Yilmaz-Oner S, Oner C, Mert Dogukan F, Filam Moses T, Demir K, Tekayev N, Atagunduz P, Tuglular S, Direskeneli H (2016) Health-related quality of life assessed by LupusQoL questionnaire and SF-36 in Turkish patients with systemic lupus erythematosus. Clin Rheumatol 35:617–622

    Google Scholar 

  18. Tay SH, Cheung PPM, Mak A (2015) Active disease is independently associated with more severe anxiety rather than depressive symptoms in patients with systemic lupus erythematosus. Lupus 24:1392–1399

    CAS  CrossRef  PubMed  Google Scholar 

  19. Karol DE, Criscione-Schreiber LG, Lin M, Clowse MEB (2013) Depressive symptoms and associated factors in systemic lupus erythematosus. Psychosomatics 54:443–450

    CrossRef  PubMed  Google Scholar 

  20. Palagini L, Tani C, Bruno RM, Gemignani A, Mauri M, Bombardieri S, Riemann D, Mosca M (2014) Poor sleep quality in systemic lupus erythematosus: does it depend on depressive symptoms? Lupus 23:1350–1357

    CAS  CrossRef  PubMed  Google Scholar 

  21. Calderon J, Flores P, Babul M, Aguirre JM, Slachevsky A, Padilla O, Scoriels L, Henriquez C, Carcamo C, Bravo-Zehnder M, Gonzalez A, Massardo L (2014) Systemic lupus erythematosus impairs memory cognitive tests not affected by depression. Lupus 23:1042–1053

    CAS  CrossRef  PubMed  Google Scholar 

  22. Bachen EA, Chesney MA, Criswell LA (2009) Prevalence of mood and anxiety disorders in women with systemic lupus erythematosus. Arthritis Rheum 61:822–829

    CrossRef  PubMed  PubMed Central  Google Scholar 

  23. Panopalis P, Yazdany J, Zell Gillis J, Julian L, Trupin L, Hersh AO, Criswell LA, Katz P, Yelin E (2008) Health care costs and costs associated with changes in work productivity among persons with systemic lupus erythematosus. Arthritis Rheum 59:1788–1795

    CrossRef  PubMed  PubMed Central  Google Scholar 

  24. Ahola Kohut S, Williams TS, Jayanthikumar J, Landolt-Marticorena C, Lefebvre A, Silverman E, Levy DM (2013) Depressive symptoms are prevalent in childhood-onset systemic lupus erythematosus (cSLE). Lupus 22:712–720

    CrossRef  PubMed  Google Scholar 

  25. Knight A, Weiss P, Morales K, Gerdes M, Rearson M, Vickery M, Keren R (2015) Identifying differences in risk factors for depression and anxiety in pediatric chronic disease: a matched cross-sectional study of youth with lupus/mixed connective tissue disease and their peers with diabetes. J Pediatr 167:1397–1403

    CrossRef  PubMed  PubMed Central  Google Scholar 

  26. Knight A, Weiss PM, Morales K, Gerdes M, Gutstein A, Vickery M, Keren R (2014) Depression and anxiety and their association with healthcare utilization in pediatric lupus and mixed connective tissue disease patients: a cross-sectional study. Pediatr Rheumatol 12:42

    CrossRef  Google Scholar 

  27. Vina ER, Hausmann LRM, Utset TO, Masi CM, Liang KP, Kent Kwoh C (2015) Perceptions of racism in healthcare among patients with systemic lupus erythematosus: a cross-sectional study. Lupus Sci Med 2:e000110

    CrossRef  PubMed  PubMed Central  Google Scholar 

  28. Karassa FB, Magliano M, Isenberg DA (2003) Suicide attempts in patients with systemic lupus erythematosus. Ann Rheum Dis 62:58–60

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  29. Mok CC, Chan KL, Cheung EFC, Yip PSF (2014) Suicidal ideation in patients with systemic lupus erythematosus: incidence and risk factors. Rheumatology (Oxford) 53:714–721

    CrossRef  Google Scholar 

  30. Xie L-F, Chen P-L, Pan H-F, Taio J-H, Li X-P, Zhang Y-J, Zhai Y, Ye D-Q (2012) Prevalence and correlates of suicidal ideation in SLE inpatients: Chinese experience. Rheumatol Int 32:2707–2714

    CrossRef  PubMed  Google Scholar 

  31. Greco CM, Li T, Sattar A, Kao AH, Danchenko N, Edmundowicz D, Sutton-Tyrrell K, Tracy RP, Kuller LH, Manzi S (2012) Association between depression and vascular disease in systemic lupus erythematosus. J Rheumatol 39:262–268

    CrossRef  PubMed  Google Scholar 

  32. Mak A, Tang CS, Ho RC (2013) Serum tumour necrosis factor-alpha is associated with poor health-related quality of life and depressive symptoms in patients with systemic lupus erythematosus. Lupus 22:254–261

    CAS  CrossRef  PubMed  Google Scholar 

  33. Kellner ES, Lee PY, Li Y, Switanek J, Zhuang H, Segal MS, Sobel ES, Satoh M, Reeves WH (2010) Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus. J Neuroimmunol 223:13–19

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  34. Xu J, Cheng YQ, Chen B, Bai R, Li S, Xu XF, Xu L, Wen JF, Lu ZP, Zeng XF (2013) Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region. Lupus 22:1001–1010

    CAS  CrossRef  PubMed  Google Scholar 

  35. Karimifar M, Sharifi I, Shafiey K (2013) Anti-ribosomal P antibodies related to depression in early clinical course of systemic lupus erythematosus. J Res Med Sci 18:860–864

    PubMed  PubMed Central  Google Scholar 

  36. Bravo-Zehnder M, Toledo EM, Segovia-Miranda F, Serrano FG, Benito MJ, Metz C, Retamal C, Alvarez A, Massardo L, Inestrosa NC, Gonzalez A (2015) Anti-ribosomal P protein autoantibodies from patients with neuropsychiatric lupus impair memory in mice. Arthritis Rheumatol 67:204–214

    CAS  CrossRef  PubMed  Google Scholar 

  37. Katzav A, Ben-Ziv T, Blank M, Pick CG, Shoenfeld Y, Chapman J (2014) Antibody-specific behavioral effects: intracerebroventricular injection of antiphospholipid antibodies induces hyperactive behavior while anti-ribosomal-P antibodies induces depression and smell deficits in mice. J Neuroimmunol 272:10–15

    CAS  CrossRef  PubMed  Google Scholar 

  38. Chang EH, Volpe BT, Mackay M, Aranow C, Watson P, Kowal C, Storbeck J, Mattis P, Berlin R, Chen H-I, Mader S, Huerta TS, Huerta PT, Diamond B (2015) Selective impairment of spatial cognition caused by autoantibodies to the N-methyl-D-aspartate receptor. EBioMedicine 2:755–764

    CrossRef  PubMed  PubMed Central  Google Scholar 

  39. Gono T, Kawaguchi Y, Yamanaka H (2013) Discoveries in the pathophysiology of neuropsychiatric lupus erythematosus: consequences for therapy. BMC Med 11:91. doi:10.1186/1741-7015-11-91

  40. Kivity S, Katzav A, Arango MT, Landau-Rabi M, Zafrir Y, Agmon-Levin N, Blank M, Anaya J-M, Mozes E, Chapman J, Shoenfeld Y (2013) 16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus. BMC Med 11:90. doi:10.1186/1741-7015-11-90

  41. Isik A, Koca SS, Ozturk A, Mermi O (2007) Anxiety and depression in patients with rheumatoid arthritis. Clin Rheumatol 26:872–878

    CrossRef  PubMed  Google Scholar 

  42. Margaretten M, Julian L, Katz P, Yelin E (2011) Depression in patients with rheumatoid arthritis: description, causes and mechanisms. Int J Clin Rheumatol 6:617–623

    CrossRef  Google Scholar 

  43. Fifield J, Reisine S, Sheehan TJ, McQuillan J (1996) Gender, paid work, and symptoms of emotional distress in rheumatoid arthritis patients. Arthritis Rheum 39:427–435

    CAS  CrossRef  PubMed  Google Scholar 

  44. Wang S-L, Chang C-H, Hu L-Y, Tsai S-J, Yang AC, You Z-H (2014) Risk of developing depressive disorders following rheumatoid arthritis: a nationwide population-based study. PLoS One 9:e107791

    CrossRef  PubMed  PubMed Central  Google Scholar 

  45. Hider SL, Tanveer W, Brownfield A, Mattey DL, Packham JC (2009) Depression in RA patients treated with anti-TNF is common and under-recognized in the rheumatology clinic. Rheumatology (Oxford) 48:1152–1154

    CrossRef  Google Scholar 

  46. Imran MY, Khan SEA, Ahmad NM, Raja SF, Saeed MA, Haider II (2015) Depression in rheumatoid arthritis and its relation to disease activity. Pak J Med Sci 31:393–397

    CrossRef  PubMed  PubMed Central  Google Scholar 

  47. Katz PP, Yelin EH (2001) Activity loss and the onset of depressive symptoms: do some activities matter more than others? Arthritis Rheum 44:1194–1202

    CAS  CrossRef  PubMed  Google Scholar 

  48. Imeri L, Opp MR (2009) How (and why) the immune system makes us sleep. Nat Rev Neurosci 10:199–210

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  49. Krueger JM (2008) The role of cytokines in sleep regulation. Curr Pharm Des 14:3408–3416

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  50. Gulinello M, Putterman C (2011) The MRL/lpr mouse strain as a model for neuropsychiatric systemic lupus erythematosus. J Biomed Biotechnol 2011:1–15, 207504

    CrossRef  Google Scholar 

  51. Gast H, Müller A, Lopez M, Meier D, Huber R, Dechent F, Prinz M, Emmenegger Y, Franken P, Birchler T, Fontana A (2013) CD40 activation induces NREM sleep and modulates genes associated with sleep homeostasis. Brain Behav Immun 27:133–144

    CAS  CrossRef  PubMed  Google Scholar 

  52. Leo R, Di Lorenzo G, Tesauro M, Razzini C, Forleo GB, Chiricolo G, Cola C, Zanasi M, Troisi A, Siracusano A, Lauro R, Romeo F (2006) Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy. J Clin Psychiatry 67:1760–1766

    CAS  CrossRef  PubMed  Google Scholar 

  53. Neubauer H, Petrak F, Zahn D, Pepinghege F, Hägele A-K, Pirkl P-A, Uhl I, Juckel G, Mügge A, Herpertz S (2013) Newly diagnosed depression is associated with increased beta-thromboglobulin levels and increased expression of platelet activation markers and platelet derived CD40-CD40L. J Psychiatr Res 47:865–871

    CrossRef  PubMed  Google Scholar 

  54. Cathomas F, Fuertig R, Sigrist H, Newman G, Hoop V, Bizzozzero M, Mueller A, Ceci A, Hengerer B, Seifritz E, Fontana A, Pryce CR (2015) CD40-induced inflammation in mice leads to sustained emotional and cognitive dysfunctions coincident with altered tryptophan metabolism: a model for depression-autoimmune disease comorbidity. Brain Behav Immun 50:125–140

    CAS  CrossRef  PubMed  Google Scholar 

  55. Taraborrelli C, Palchykova S, Tobler I, Gast H, Birchler T, Fontana A (2011) TNFR1 is essential for CD40, but not for lipopolysaccharide-induced sickness behavior and clock gene dysregulation. Brain Behav Immun 25:434–442

    CAS  CrossRef  PubMed  Google Scholar 

  56. Eckel-Mahan K, Sassone-Corsi P (2013) Metabolism and the circadian clock converge. Physiol Rev 93:107–135

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  57. Franken P, Dijk D-J (2009) Circadian clock genes and sleep homeostasis. Eur J Neurosci 29:1820–1829

    CAS  CrossRef  PubMed  Google Scholar 

  58. Dibner C, Schibler U, Albrecht U (2010) The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol 72:517–549

    CAS  CrossRef  PubMed  Google Scholar 

  59. Reick M, Garcia JA, Dudley C, McKnight SL (2001) NPAS2: an analog of clock operative in the mammalian forebrain. Science 293:506–509

    CAS  CrossRef  PubMed  Google Scholar 

  60. Parry BL, Meliska CJ, Sorenson DL, Lopez AM, Martinez LF, Nowakowski S, Elliott JA, Hauger RL, Kripke DF (2008) Plasma melatonin circadian rhythm disturbances during pregnancy and postpartum in depressed women and women with personal or family histories of depression. Am J Psychiatry 165:1551–1558

    CrossRef  PubMed  PubMed Central  Google Scholar 

  61. Soria V, Martinez-Amoros E, Escaramis G, Valero J, Perez-Egea R, Garcia C, Gutierrez-Zotes A, Puigdemont D, Bayes M, Crespo JM, Martorell L, Vilella E, Labad A, Vallejo J, Perez V, Menchon JM, Estivill X, Gratacos M, Urretavizcaya M (2010) Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. Neuropsychopharmacology 35:1279–1289

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  62. Li S-X, Liu L-J, Xu L-Z, Gao L, Wang X-F, Zhang J-T, Lu L (2013) Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment. Psychoneuroendocrinology 38:2789–2799

    CAS  CrossRef  PubMed  Google Scholar 

  63. Bellet MM, Deriu E, Liu JZ, Grimaldi B, Blaschitz C, Zeller M, Edwards RA, Sahar S, Dandekar S, Baldi P, George MD, Raffatellu M, Sassone-Corsi P (2013) Circadian clock regulates the host response to Salmonella. Proc Natl Acad Sci U S A 110:9897–9902

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  64. Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk H-D, Kramer A, Maier B (2009) A circadian clock in macrophages controls inflammatory immune responses. Proc Natl Acad Sci U S A 106:21407–21412

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  65. Cavadini G, Petrzilka S, Kohler P, Jud C, Tobler I, Birchler T, Fontana A (2007) TNF-a suppresses the expression of clock genes by interfering with E-box-mediated transcription. Proc Natl Acad Sci U S A 104:12843–12848

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  66. Petrzilka S, Taraborrelli C, Cavadini G, Fontana A, Birchler T (2009) Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling. J Biol Rhythms 24:283–294

    CAS  CrossRef  PubMed  Google Scholar 

  67. Lopez M, Meier D, Müller A, Franken P, Fujita J, Fontana A (2014) Tumor necrosis factor and transforming growth factor B regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP). J Biol Chem 289:2736–2744

    CAS  CrossRef  PubMed  Google Scholar 

  68. Meier D, Lopez M, Franken P, Fontana A (2015) Twist1 is a TNF-inducible inhibitor of clock mediated activation of period genes. PLoS One 10:e0137229

    CrossRef  PubMed  PubMed Central  Google Scholar 

  69. Hashiramoto A, Yamane T, Tsumiyama K, Yoshida K, Komai K, Yamada H, Yamazaki F, Doi M, Okamura H, Shiozawa S (2010) Mammalian clock gene cryptochrome regulates arthritis via proinflammatory cytokine TNF-alpha. J Immunol 184:1560–1565

    CAS  CrossRef  PubMed  Google Scholar 

  70. Yoshida K, Hashiramoto A, Okano T, Yamane T, Shibanuma N, Shiozawa S (2013) TNF-a modulates expression of the circadian clock gene Per2 in rheumatoid synovial cells. Scand J Rheumatol 42:276–280

    CAS  CrossRef  PubMed  Google Scholar 

  71. Spies CM, Hoff P, Mazuch J, Gaber T, Maier B, Strehl C, Hahne M, Jakstadt M, Huscher D, Burmester GR, Detert J, Kramer A, Buttgereit F (2015) Circadian rhythms of cellular immunity in rheumatoid arthritis: a hypothesis-generating study. Clin Exp Rheumatol 33:34–43

    PubMed  Google Scholar 

  72. Palmieri O, Mazzoccoli G, Bossa F, Maglietta R, Palumbo O, Ancona N, Corritore G, Latiano T, Martino G, Rubino R, Biscaglia G, Scimeca D, Carella M, Annese V, Andriulli A, Latiano A (2015) Systematic analysis of circadian genes using genome-wide cDNA microarrays in the inflammatory bowel disease transcriptome. Chronobiol Int 32:903–916

    CrossRef  PubMed  Google Scholar 

  73. Habbas S, Santello M, Becker D, Stubbe H, Zappia G, Liaudet N, Klaus F, Kollias G, Fontana A, Pryce CR, Suter T, Volterra A (2015) Neuroinflammatory TNFa impairs memory via astrocyte signaling. Cell 163:1730–1741

    CAS  CrossRef  PubMed  Google Scholar 

  74. Piani D, Frei K, Cuenod M, Fontana A (1991) Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate. Neurosci Lett 133:159–162

    CAS  CrossRef  PubMed  Google Scholar 

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Acknowledgments

The work was supported by the Swiss National Science Foundation (Project 141055), the Baugarten Stiftung, the Lotex Foundation and the Swiss Multiple Sclerosis Society to A.F., and the Swiss National Science Foundation (Project 141137) to C.R.P. Adriano Fontana is Hertie Senior Research Professor for Neuroscience of the Gemeinnützige Hertie-Stiftung.

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Pryce, C.R., Fontana, A. (2016). Depression in Autoimmune Diseases. In: Dantzer, R., Capuron, L. (eds) Inflammation-Associated Depression: Evidence, Mechanisms and Implications. Current Topics in Behavioral Neurosciences, vol 31. Springer, Cham. https://doi.org/10.1007/7854_2016_7

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