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Depression in Autoimmune Diseases

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Inflammation-Associated Depression: Evidence, Mechanisms and Implications

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 31))

Abstract

Up to 50% of patients with autoimmune diseases show an impairment of health-related quality of life and exhibit depression-like symptoms. The immune system not only leads to inflammation in affected organs, but also mediates behavior abnormalities including fatigue and depression-like symptoms. This review focuses on the different pathways involved in the communication of the immune system with the neuronal network and the body’s timing system. The latter is built up by a hierarchically organized expression of clock genes. As discussed here, the activation of the immune system interferes with high amplitude expression of clock genes, an effect which may play a pivotal role in depression-like behavior in autoimmune diseases.

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Acknowledgments

The work was supported by the Swiss National Science Foundation (Project 141055), the Baugarten Stiftung, the Lotex Foundation and the Swiss Multiple Sclerosis Society to A.F., and the Swiss National Science Foundation (Project 141137) to C.R.P. Adriano Fontana is Hertie Senior Research Professor for Neuroscience of the Gemeinnützige Hertie-Stiftung.

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Authors and Affiliations

  1. Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy & Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland

    Christopher R. Pryce

  2. Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland

    Adriano Fontana

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  1. Christopher R. Pryce
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Correspondence to Adriano Fontana .

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Editors and Affiliations

  1. Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Robert Dantzer

  2. Nutrition and Integrative Neurobiology, INRA, University of Bordeaux, Bordeaux, France

    Lucile Capuron

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Pryce, C.R., Fontana, A. (2016). Depression in Autoimmune Diseases. In: Dantzer, R., Capuron, L. (eds) Inflammation-Associated Depression: Evidence, Mechanisms and Implications. Current Topics in Behavioral Neurosciences, vol 31. Springer, Cham. https://doi.org/10.1007/7854_2016_7

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