Chapter

Neuropharmacology of New Psychoactive Substances (NPS)

Volume 32 of the series Current Topics in Behavioral Neurosciences pp 333-350

Date:

Application of a Combined Approach to Identify New Psychoactive Street Drugs and Decipher Their Mechanisms at Monoamine Transporters

  • Felix P. MayerAffiliated withCenter of Physiology and Pharmacology, Institute of Pharmacology, Medical University Vienna
  • , Anton LufAffiliated withClinical Department of Laboratory Medicine, Medical University of Vienna
  • , Constanze NagyAffiliated withcheckit! – Suchthilfe Wien GmbH
  • , Marion HolyAffiliated withCenter of Physiology and Pharmacology, Institute of Pharmacology, Medical University Vienna
  • , Rainer SchmidAffiliated withClinical Department of Laboratory Medicine, Medical University of Vienna
  • , Michael FreissmuthAffiliated withCenter of Physiology and Pharmacology, Institute of Pharmacology, Medical University Vienna
  • , Harald H. SitteAffiliated withCenter of Physiology and Pharmacology, Institute of Pharmacology, Medical University ViennaCenter for Addiction Research and Science – Medical University Vienna Email author 

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Abstract

Psychoactive compounds can cause acute and long-term health problems and lead to addiction. In addition to well-studied and legally controlled compounds like cocaine, new psychoactive substances (NPS) are appearing in street drug markets as replacement strategies and legal alternatives. NPS are effectively marketed as “designer drugs” or “research chemicals” without any knowledge of their underlying pharmacological mode of action and their potential toxicological effects and obviously devoid of any registration process. As of 2016, the knowledge of structure–activity relationships for most NPS is scarce, and predicting detailed pharmacological activity of newly emerging drugs is a challenging task. Therefore, it is important to combine different approaches and employ biological test systems that are superior to mere chemical analysis in recognizing novel and potentially harmful street drugs. In this chapter, we provide a detailed description of techniques to decipher the molecular mechanism of action of NPS that target the high-affinity transporters for dopamine, norepinephrine, and serotonin. In addition, this chapter provides insights into a combined approach to identify and characterize new psychoactive street drugs of unknown content in a collaboration with the Austrian prevention project “checkit!.”

Keywords

Amphetamine Analytical identification Bath salts Cocaine Dopamine Monoamine transporters New psychoactive substances Norepinephrine Psychostimulants Research chemicals Serotonin