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Sleep Deprivation Therapy for Depression

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Sleep, Neuronal Plasticity and Brain Function

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 25))

Abstract

Sleep deprivation (SD) is the most widely documented rapid-onset antidepressant therapy, targeting the broadly defined depressive syndrome. Although SD responses are transient, its effects can be sustained by concomitant medications (e.g., selective serotonin reuptake inhibitors and lithium) and circadian-related interventions (e.g., bright light and sleep phase advance). Thus, considering its safety, this technique can now be considered among the first-line antidepressant treatment strategies for patients affected by mood disorders. SD is a complex intervention and it should be considered multi-target in nature. Thus, the mechanisms explaining its antidepressant effect can be looked for on many levels, involving not only monoaminergic mechanisms but also sleep homeostatic and circadian mechanisms, glutamatergic mechanisms and synaptic plasticity.

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Authors and Affiliations

  1. Department of Clinical Neurosciences, Scientific Institute, University Vita-Salute San Raffaele, Milano, Italy

    Sara Dallaspezia & Francesco Benedetti

  2. Dipartimento di Neuroscienze Cliniche, Istituto Scientifico Universitario Ospedale San Raffaele, San Raffaele Turro, Via Stamira d’Ancona 20, 20127, Milano, Italy

    Sara Dallaspezia

Authors
  1. Sara Dallaspezia
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  2. Francesco Benedetti
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Corresponding author

Correspondence to Sara Dallaspezia .

Editor information

Editors and Affiliations

  1. Center for Behavior and Neurosciences, University of Groningen, Groningen, The Netherlands

    Peter Meerlo

  2. Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA

    Ruth M. Benca

  3. Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Ted Abel

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© 2014 Springer-Verlag Berlin Heidelberg

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Dallaspezia, S., Benedetti, F. (2014). Sleep Deprivation Therapy for Depression. In: Meerlo, P., Benca, R., Abel, T. (eds) Sleep, Neuronal Plasticity and Brain Function. Current Topics in Behavioral Neurosciences, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2014_363

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