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Electrophysiological Aberrations Associated with Negative Symptoms in Schizophrenia

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Electrophysiology and Psychophysiology in Psychiatry and Psychopharmacology

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 21))

Abstract

Clinical heterogeneity is a confound common to all of schizophrenia research. Deficit schizophrenia has been proposed as a homogeneous disease entity within the schizophrenia syndrome. The use of the Schedule for the Deficit Syndrome (SDS) has allowed the definition of a subgroup dominated by persistent and primary negative symptoms. While a number of studies have appeared over the years examining the electrophysiological correlates of the cluster of negative symptoms in schizophrenia, only a few studies have actually focused on the Deficit Syndrome (DS). In this chapter, electrophysiological investigations utilizing EEG, Evoked Potentials (EPs), polysomnography (PSG), or magnetoencephalography (MEG) to probe “negative symptoms,” or “Deficit Syndrome” are reviewed. While this line of research is evidently in its infancy, two significant trends emerge. First, spectral EEG studies link increased slow wave activity during wakefulness to the prevalence of negative symptoms. Second, sleep studies point to an association between decrease in slow wave sleep and prevalence of negative symptoms. Several studies also indicate a relationship of negative symptoms with reduced alpha activity. A host of other abnormalities including sensory gating and P300 attenuation are less consistently reported. Three studies specifically addressed electrophysiology of the DS. Two of the three studies provided evidence suggesting that the DS may be a separate disease entity and not simply a severe form of schizophrenia.

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Acknowledgements

No support was received for the development of this chapter.

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Authors and Affiliations

  1. Department of Psychiatry and Neurosciences, University of Missouri Kansas City (UMKC), 1000 East 24th Street, Kansas City, MO, 64108, USA

    Nash N. Boutros

  2. Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138, Naples, Italy

    Armida Mucci, Annarita Vignapiano & Silvana Galderisi

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  1. Nash N. Boutros
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  2. Armida Mucci
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  4. Silvana Galderisi
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Correspondence to Nash N. Boutros .

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  1. Department of Psychology,, Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom

    Veena Kumari

  2. Center for Neuropsych Research of Traumatic Stress, Charles University Department of Psychiatry, Prague, Czech Republic

    Petr Bob

  3. Department of Psychiatry and Neurosciences, Department of Psychiatry and Neurosciences, University of Missouri Kansas City (UMKC), Kansas City, Missouri, USA

    Nash N. Boutros

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© 2014 Springer-Verlag Berlin Heidelberg

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Boutros, N.N., Mucci, A., Vignapiano, A., Galderisi, S. (2014). Electrophysiological Aberrations Associated with Negative Symptoms in Schizophrenia. In: Kumari, V., Bob, P., Boutros, N. (eds) Electrophysiology and Psychophysiology in Psychiatry and Psychopharmacology. Current Topics in Behavioral Neurosciences, vol 21. Springer, Cham. https://doi.org/10.1007/7854_2014_303

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