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Mechanisms and Pharmacology of Neuropathic Pain in Multiple Sclerosis

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Behavioral Neurobiology of Chronic Pain

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 20))

Abstract

The neuropathic pain of multiple sclerosis is quite prevalent and severely impacts quality of life. A few randomized, placebo-controlled, blinded clinical trials suggest that cannabis- and anticonvulsant-based treatments provide partial pain relief, but at the expense of adverse events. An even smaller, but emerging, number of translational studies are using rodent models of experimental autoimmune encephalomyelitis (EAE), which exhibit pain-like behaviors resembling those of Multiple sclerosis (MS) patients. These studies not only support the possible effectiveness of anticonvulsants, but also compel further clinical trials with serotonin–norepinephrine reuptake inhibitors, the immunosuppressant drug rapamycin, or drugs which interfere with glutamatergic neurotransmission. Future behavioral studies in EAE models are essential toward a new pharmacotherapy of multiple sclerosis pain.

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Authors and Affiliations

  1. Department of Physiology, School of Medicine, University of Kentucky Medical Center, Lexington, KY, 40536-0298, USA

    T. Iannitti & B. K. Taylor

  2. Department of Anesthesiology and Pain Medicine and Centre for Neuroscience, University of Alberta, Edmonton, AB, T6G-2G3, Canada

    B. J. Kerr

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  1. T. Iannitti
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  2. B. J. Kerr
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  3. B. K. Taylor
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Correspondence to B. K. Taylor .

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Editors and Affiliations

  1. University of Kentucky Medical Center, Lexington, Kentucky, USA

    Bradley K. Taylor

  2. Centre for Pain Research, National University of Ireland, Galway, Ireland

    David P. Finn

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Iannitti, T., Kerr, B.J., Taylor, B.K. (2014). Mechanisms and Pharmacology of Neuropathic Pain in Multiple Sclerosis. In: Taylor, B., Finn, D. (eds) Behavioral Neurobiology of Chronic Pain. Current Topics in Behavioral Neurosciences, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2014_288

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