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Dopamine-Based Reward Circuitry Responsivity, Genetics, and Overeating

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Behavioral Neurobiology of Eating Disorders

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 6))

Abstract

Data suggest that low levels of dopamine D2 receptors and attenuated responsivity of dopamine-target regions to food intake is associated with increased eating and elevated weight. There is also growing (although mixed) evidence that genotypes that appear to lead to reduced dopamine signaling (e.g., DRD2, DRD4, and DAT) and certain appetite-related hormones and peptides (e.g., ghrelin, orexin A, leptin) moderate the relation between dopamine signaling, overeating, and obesity. This chapter reviews findings from studies that have investigated the relation between dopamine functioning and food intake and how certain genotypes and appetite-related hormones and peptides affect this relation.

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Authors and Affiliations

  1. Oregon Research Institute, Eugene, OR, USA

    Eric Stice & Sonja Yokum

  2. Vanderbilt University, Nashville, TN, USA

    David Zald

  3. McGill University, Montreal, QC, Canada

    Alain Dagher

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  1. Eric Stice
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  2. Sonja Yokum
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  3. David Zald
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  4. Alain Dagher
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Correspondence to Eric Stice .

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Editors and Affiliations

  1. Neuroscience, Dept. Pharmacology, Rudolf Magnus Institute of, Universiteitsweg 100, Utrecht, 3508 AB, Netherlands

    Roger A.H. Adan

  2. Dept. Psychiatry, University of California, San Diego, La Jolla Drive 8950, La Jolla, 92037, California, USA

    Walter H. Kaye

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Stice, E., Yokum, S., Zald, D., Dagher, A. (2010). Dopamine-Based Reward Circuitry Responsivity, Genetics, and Overeating. In: Adan, R., Kaye, W. (eds) Behavioral Neurobiology of Eating Disorders. Current Topics in Behavioral Neurosciences, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2010_89

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