Skip to main content
SpringerLink
Log in

Neurophysiological Measures of Sensory Registration, Stimulus Discrimination, and Selection in Schizophrenia Patients

  • Chapter
  • First Online:
Behavioral Neurobiology of Schizophrenia and Its Treatment

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 4))

Abstract

Cortical Neurophysiological event related potentials (ERPs) are multidimensional measures of information processing that are well suited to efficiently parse automatic and controlled components of cognition that span the range of deficits exhibited in schizophrenia patients. Components following a stimulus reflect the sequence of neural processes triggered by the stimulus, beginning with early automatic sensory processes and proceeding through controlled decision and response related processes. Previous studies employing ERP paradigms have reported deficits of information processing in schizophrenia across automatic through attention dependent processes including sensory registration (N1), automatic change detection (MMN), the orienting or covert shift of attention towards novel or infrequent stimuli (P3a), and attentional allocation following successful target detection processes (P3b). These automatic and attention dependent information components are beginning to be recognized as valid targets for intervention in the context of novel treatment development for schizophrenia and related neuropsychiatric disorders. In this review, we describe three extensively studied ERP components (N1, mismatch negativity, P300) that are consistently deficient in schizophrenia patients and may serve as genetic endophenotypes and as quantitative biological markers of response outcome.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adler L, Freedman R, Ross R, Waldo M (1999) Elementary phenotypes in the neurobiological and genetic study of schizophrenia. Biol Psychiatry 4:8–18

    Article  Google Scholar 

  • Ahveninen J, Jääskeläinen I, Osipova D, Huttunen M, Ilmoniemi RJ, Kaprio J, Lönnqvist J, Manninen M, Pakarinen S, Therman S, Näätänen R, Cannon TD (2006) Inherited auditory-cortical dysfunction in twin pairs discordant for schizophrenia. Biol Psychiatry 60:612–620

    Article  PubMed  Google Scholar 

  • Alain C, Woods D (1997) Attention modulates auditory pattern memory as indexed by event-related brain potentials. Psychophysiology 34:534–546

    Article  PubMed  CAS  Google Scholar 

  • Alain C, Hargrave R, Woods D (1998) Processing of auditory stimuli during visual attention in patients with schizophrenia. Biol Psychiatry 44:1151–1159

    Article  PubMed  CAS  Google Scholar 

  • Alho K (1992) Selective attention in auditory processing as reflected by event-related brain potentials. Psychophysiology 29:247–263

    Article  PubMed  CAS  Google Scholar 

  • Alho K, Tervaniemi M, Huotilainen M, Lavikainen J, Tiitinen H, Ilmoniemi R, Knuutila J, Näätänen R (1996) Processing of complex sounds in the human auditory cortex as revealed by magnetic brain responses. Psychophysiology 33:369–375

    Article  PubMed  CAS  Google Scholar 

  • Almasy L, Blangero J (2001) Endophenotypes as quantitative risk factors for psychiatric disease: rationale and study design. Am J Med Genet 105:42–44

    Article  PubMed  CAS  Google Scholar 

  • Amenedo E, Escera C (2000) The accuracy of sound duration representation in the human brain determines the accuracy of behavioural perception. Eur J Neurosci 12:2570–2574

    Article  PubMed  CAS  Google Scholar 

  • Bar-Haim Y, Marshall P, Fox N, Schorr E, Gordon-Salant S (2003) Mismatch negativity in socially withdrawn children. Biol Psychiatry 54:17–24

    Article  PubMed  Google Scholar 

  • Bearden CE, Freimer NB (2006) Endophenotypes for psychiatric disorders: ready for primetime? Trends Genet 22:306–313

    Article  PubMed  CAS  Google Scholar 

  • Berti S, Roeber U, Schröger E (2004) Bottom-up influences on working memory: behavioral and electrophysiological distraction varies with distractor strength. Exp Psychol 51:249–257

    Article  PubMed  Google Scholar 

  • Blackwood D, Muir W (2004) Clinical phenotypes associated with DISC1, a candidate gene for schizophrenia. Neurotox Res 6:35–41

    Article  PubMed  CAS  Google Scholar 

  • Blackwood D, Whalley L, Christie J, Blackburn I, St Clair D, McInnes A (1987) Changes in auditory P3 event-related potential in schizophrenia and depression. Br J Psychiatry 150:154–160

    Article  PubMed  CAS  Google Scholar 

  • Blackwood D, St Clair D, Muir W, Duffy J (1991) Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees. Arch Gen Psychiatry 48:899–909

    Article  PubMed  CAS  Google Scholar 

  • Boutros N, Korzyukov O, Jansen B, Feingold A, Bell M (2004) Sensory gating deficits during the mid-latency phase of information processing in medicated schizophrenia patients. Psychiatry Res 126:203–215

    Article  PubMed  Google Scholar 

  • Braff D (1993) Information processing and attention dysfunctions in schizophrenia. Schizophr Bull 19:233–259

    Article  PubMed  CAS  Google Scholar 

  • Braff D, Freedman R (2002) Endophenotypes in studies of the genetics of schizophrenia. In: Davis KL, Charney DS, Coyle JT, Nemeroff C (eds) Neuropsychopharmacology: the fifth generation of progress. Linppincott Williams & Wilkins, Philadelphia, pp 703–716

    Google Scholar 

  • Braff D, Light G (2004) Preattentional and attentional cognitive deficits as targets for treating schizophrenia. Psychopharmacology (Berl) 174:75–85

    Article  CAS  Google Scholar 

  • Braff D, Light G (2005) The use of neurophysiological endophenotypes to understand the genetic basis of schizophrenia. Dialogues Clin Neurosci 7:125–135

    PubMed  Google Scholar 

  • Braff D, Swerdlow N, Geyer M (1999) Symptom correlates of prepulse inhibition deficits in male schizophrenic patients. Am J Psychiatry 156:596–602

    PubMed  CAS  Google Scholar 

  • Braff D, Swerdlow NR, Light GA, Greenwood TA, Schork NJ, the COGS investigators (2008) Advances in endophenotyping schizophrenia: the consortium on the genetics of schizophrenia (COGS). World Psychiatry 7:11–18

    PubMed  Google Scholar 

  • Bramon E, Croft R, McDonald C, Virdi GK, Gruzelier JG, Baldeweg T, Sham PC, Frangou S, Murray RM (2004) Mismatch negativity in schizophrenia: a family study. Schizophr Res 67:1–10

    Article  PubMed  Google Scholar 

  • Brockhaus-Dumke A, Tendolkar I, Pukrop R, Schultze-Lutter F, Klosterkotter J, Ruhrmann S (2005) Impaired mismatch negativity generation in prodromal subjects and patients with schizophrenia. Schizophr Res 73:297–310

    Article  PubMed  Google Scholar 

  • Clementz BA, Blumenfeld LD (2001) Multichannel electroencephalographic assessment of auditory evoked response suppression in schizophrenia. Exp Brain Res 139:377–390

    Article  PubMed  CAS  Google Scholar 

  • Coburn K, Shillcutt S, Tucker K, Estes K, Brin F, Merai P, Moore N (1998) P300 delay and attenuation in schizophrenia: reversal by neuroleptic medication. Biol Psychiatry 44:466–474

    Article  PubMed  CAS  Google Scholar 

  • Connolly P, Maxwell C, Liang Y, Kahn J, Kanes S, Abel T, Gur R, Turetsky B, Siegel S (2004) The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP components. Neurochem Res 29:1179–1188

    Article  PubMed  CAS  Google Scholar 

  • Cortiñas M, Corral M, Garrido G, Garolera M, Pajares M, Escera C (2008) Reduced novelty-P3 associated with increased behavioral distractibility in schizophrenia. Biol Psychol 78:253–260

    Article  PubMed  Google Scholar 

  • Coull J (1998) Neural correlates of attention and arousal: insights from electrophysiology, functional neuroimaging and psychopharmacology. Prog Neurobiol 55:343–361

    Article  PubMed  CAS  Google Scholar 

  • Donchin E, Coles M (1988) Is the P300 component a manifestation of context updating? Behav Brain Sci 11:357–374

    Article  Google Scholar 

  • Draganova R, Eswaran H, Murphy P, Huotilainen M, Lowery C, Preissl H (2005) Sound frequency change detection in fetuses and newborns, a magnetoencephalographic study. Neuroimage 28:354–361

    Article  PubMed  Google Scholar 

  • Duncan CC (1988) Event-related brain potentials: a window on information processing in schizophrenia. Schizophr Bull 14:199–203

    Article  PubMed  CAS  Google Scholar 

  • Ebmeier K (1991) Effect sizes of P300 in schizophrenics. Biol Psychiatry 29:1159–1160

    Article  PubMed  CAS  Google Scholar 

  • Egan MF, Duncan CC, Suddath RL, Kirch DG, Mirsky AF, Wyatt RJ (1994) Event-related potential abnormalities correlate with structural brain alterations and clinical features in patients with chronic schizophrenia. Schizophr Res 11:259–271

    Article  PubMed  CAS  Google Scholar 

  • Escera C, Alho K, Winkler I, Näätänen R (1998) Neural mechanisms of involuntary attention to acoustic novelty and change. J Cogn Neurosci 10:590–604

    Article  PubMed  CAS  Google Scholar 

  • Escera C, Yago E, Polo M, Grau C (2000) The individual replicability of mismatch negativity at short and long interstimulus intervals. Clin Neurophysiol 111:546–551

    Article  PubMed  CAS  Google Scholar 

  • Escera C, Corral M, Yago E (2002) An electrophysiological and behavioral investigation of involuntary attention towards auditory frequency, duration and intensity changes. Cogn Brain Res 14:325–332

    Article  Google Scholar 

  • Faux S, Shenton M, McCarley R, Nestor P, Marcy B, Ludwig A (1990) Preservation of P300 event-related potential topographic asymmetries in schizophrenia with use of either linked-ear or nose reference sites. Electroencephalogr Clin Neurophysiol 75:378–391

    Article  PubMed  CAS  Google Scholar 

  • Faux SF, McCarley RW, Nestor PG, Shenton ME, Pollak SD, Penhune V, Mondrow E, Marcy B, Peterson A, Horvath T et al (1993) P300 topographic asymmetries are present in unmedicated schizophrenics. Electroencephalogr Clin Neurophysiol 88(1):32–41

    Google Scholar 

  • Fischer C, Morlet D, Giard M (2000) Mismatch negativity and N100 in comatose patients. Audiol Neurootol 5:192–197

    Article  PubMed  CAS  Google Scholar 

  • Ford J, Pfefferbaum A, Roth W (1992) P3 and schizophrenia. Ann N Y Acad Sci 658:146–162

    Article  PubMed  CAS  Google Scholar 

  • Frangou S, Sharma T, Alarcon G, Sigmudsson T, Takei N, Binnie C, Murray RM (1997) The Maudsley family study, II: Endogenous event-related potentials in familial schizophrenia. Schizophr Res 23:45–53

    Article  PubMed  CAS  Google Scholar 

  • Freedman R, Adler LE, Waldo MC, Pachtman E, Franks RD (1983) Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients. Biol Psychiatry 18:537–551

    PubMed  CAS  Google Scholar 

  • Friedman D, Cornblatt B, Vaughan H, Erlenmeyer-Kimling L (1988) Auditory event-related potentials in children at risk for schizophrenia: the complete initial sample. Psychiatry Res 26:203–221

    Article  PubMed  CAS  Google Scholar 

  • Gaeta H, Friedman D, Hunt G (2003) Stimulus characteristics and task category dissociate the anterior and posterior aspects of novelty P3. Psychophysiology 40:198–208

    Article  PubMed  Google Scholar 

  • Gallinat J, Senkowski D, Wernicke C, Juckel G, Becker I, Sander T, Smolka M, Hegerl U, Rommelspacher H, Winterer G (2003) Allelic variants of the functional promoter polymorphism of the human serotonin transporter gene is associated with auditory cortical stimulus processing. Neuropsychopharmacology 28:530–532

    Article  PubMed  CAS  Google Scholar 

  • Giard M, Perrin F, Pernier J, Bouchet P (1990) Brain generators implicated in the processing of auditory stimulus deviance: a topographic event-related potential study. Psychophysiology 27:627–640

    Article  PubMed  CAS  Google Scholar 

  • Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636–645

    Article  PubMed  Google Scholar 

  • Green MF (1996) What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 153:321–330

    PubMed  CAS  Google Scholar 

  • Green M, Kern R, Braff D, Mintz J (2000) Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”? Schizophr Bull 26:119–136

    Article  PubMed  CAS  Google Scholar 

  • Grillon C, Courchesne E, Ameli R, Geyer M, Braff D (1990) Increased distractibility in schizophrenic patients. Electrophysiologic and behavioral evidence. Arch Gen Psychiatry 47:171–179

    Article  PubMed  CAS  Google Scholar 

  • Hall MH, Schulze K, Rijsdijk F, Picchioni M, Ettinger U, Bramon E, Freedman R, Murray RM, Sham P (2006) Heritability and reliability of P300, P50 and duration mismatch negativity. Behav Genet 36:845–857

    Article  PubMed  Google Scholar 

  • Hillyard SA, Anllo-Vento L (1998) Event-related brain potentials in the study of visual selective attention. Proc Natl Acad Sci USA 95:781–787

    Article  PubMed  CAS  Google Scholar 

  • Hirayasu Y, Asato N, Ohta H, Hokama H, Arakaki H, Ogura C (1998a) Abnormalities of auditory event-related potentials in schizophrenia prior to treatment. Biol Psychiatry 43:244–253

    Article  PubMed  CAS  Google Scholar 

  • Hirayasu Y, Shenton ME, Salisbury DF, Dickey CC, Fischer IA, Mazzoni P, Kisler T, Arakaki H, Kwon JS, Anderson JE, Yurgelun-Todd D, Tohen M, McCarley RW (1998b) Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. Am J Psychiatry 155:1384–1391

    PubMed  CAS  Google Scholar 

  • Horváth J, Winkler I, Bendixen A (2008) Do N1/MMN, P3a, and RON form a strongly coupled chain reflecting the three stages of auditory distraction? Biol Psychol 79:139–147

    Article  PubMed  Google Scholar 

  • Huotilainen M, Kujala A, Hotakainen M, Shestakova A, Kushnerenko E, Parkkonen L, Fellman V, Näätänen R (2003) Auditory magnetic responses of healthy newborns. NeuroReport 14:1871–1875

    Article  PubMed  Google Scholar 

  • Iacono WG, Carlson SR, Malone SM (2000) Identifying a multivariate endophenotype for substance use disorders using psychophysiological measures. Int J Psychophysiol 38:81–96

    Article  PubMed  CAS  Google Scholar 

  • Iwanami A, Suga I, Kanamori R (1994) N1 component derived from the temporal region during an auditory passive event-related potential paradigm in schizophrenics. Clin Electroencephalogr 25:50–53

    PubMed  CAS  Google Scholar 

  • Iwanami A, Okajima Y, Kuwakado D, Isono H, Kasai K, Hata A, Nakagome K, Fukuda M, Kamijima K (2000) Event-related potentials and thought disorder in schizophrenia. Schizophr Res 42:187–191

    Article  PubMed  CAS  Google Scholar 

  • Javitt DC (2000) Intracortical mechanisms of mismatch negativity dysfunction in schizophrenia. Audiol Neurootol 5:207–215

    Article  PubMed  CAS  Google Scholar 

  • Javitt DC, Shelley A, Ritter W (2000a) Associated deficits in mismatch negativity generation and tone matching in schizophrenia. Clin Neurophysiol 111:1733–1737

    Article  PubMed  CAS  Google Scholar 

  • Javitt DC, Shelley AM, Silipo G, Lieberman JA (2000b) Deficits in auditory and visual context-dependent processing in schizophrenia: defining the pattern. Arch Gen Psychiatry 57:1131–1137

    Article  PubMed  CAS  Google Scholar 

  • Jessen F, Fries T, Kucharski C, Nishimura T, Hoenig K, Maier W, Falkai P, Heun R (2001) Amplitude reduction of the mismatch negativity in first-degree relatives of patients with schizophrenia. Neurosci Lett 309:185–188

    Article  PubMed  CAS  Google Scholar 

  • Johnson R (1993) On the neural generators of the P300 component of the event related potential. Psychophysiology 30:90–97

    Article  PubMed  Google Scholar 

  • Johnston WA, Heinz SP (1978) Flexibility and capacity demands of attention. J Exp Psychol 107:420–435

    Article  Google Scholar 

  • Joutsiniemi S, Ilvonen T, Sinkkonen J, Huotilainen M, Tervaniemi M, Lehtokoski A, Rinne T, Näätänen R (1998) The mismatch negativity for duration decrement of auditory stimuli in healthy subjects. Electroencephalogr Clin Neurophysiol 108:154–159

    Article  PubMed  CAS  Google Scholar 

  • Kaipio M, Novitski N, Tervaniemi M, Alho K, Öhman J, Salonen O, Näätänen R (2001) Fast vigilance decrement in closed head injury patients as reflected by the mismatch negativity (MMN). NeuroReport 12:1517

    Article  PubMed  CAS  Google Scholar 

  • Kane NM, Curry SH, Rowlands CA, Manara AR, Lewis T, Moss T, Cummins BH, Butler SR (1996) Event-related potentials–neurophysiological tools for predicting emergence and early outcome from traumatic coma. Intensive Care Med 22:39–46

    Article  PubMed  CAS  Google Scholar 

  • Karniski W, Blair R (1989) Topographical and temporal stability of the P300. Electroencephalogr Clin Neurophysiol 72:373

    Article  PubMed  CAS  Google Scholar 

  • Karoumi B, Laurent A, Rosenfeld F, Rochet T, Brunon A, Dalery J, d’Amato T, Saoud M (2000) Alteration of event related potentials in siblings discordant for schizophrenia. Schizophr Res 41:325–334

    Article  PubMed  CAS  Google Scholar 

  • Katayama J, Polich J (1998) Stimulus context determines P3a and P3b. Psychophysiology 35:23–33

    Article  PubMed  CAS  Google Scholar 

  • Kathmann N, Frodl-Bauch T, Hegerl U (1999) Stability of the mismatch negativity under different stimulus and attention conditions. Clin Neurophysiol 110:317–323

    Article  PubMed  CAS  Google Scholar 

  • Kawakubo Y, Kamio S, Nose T, Iwanami A, Nakagome K, Fukuda M, Kato N, Rogers MA, Kasai K (2007) Phonetic mismatch negativity predicts social skills acquisition in schizophrenia. Psychiatry Res 152:261–265

    Article  PubMed  Google Scholar 

  • Kawasaki Y, Maeda Y, Higashima M, Nagasawa T, Koshino Y, Suzuki M, Ide Y (1997) Reduced auditory P300 amplitude, medial temporal volume reduction and psychopathology in schizophrenia. Schizophr Res 26:107–115

    Article  PubMed  CAS  Google Scholar 

  • Kiang M, Kutas M, Light G, Braff D (2007) Electrophysiological insights into conceptual disorganization in schizophrenia. Schizophr Res 92:235–236

    Article  Google Scholar 

  • Kiang M, Kutas M, Light G, Braff D (2008) An event-related brain potential study of direct and indirect semantic priming in schizophrenia. Am J Psychiatry 165:74–81

    Article  PubMed  Google Scholar 

  • Kiang M, Braff DL, Sprock J, Light GA (2009) The relationship between preattentive sensory processing deficits and age in schizophrenia patients. Clin Neurophysiol 120:1949–1957

    Article  PubMed  Google Scholar 

  • Kidogami Y, Yoneda H, Asaba H, Sakai T (1992) P300 in first degree relatives of schizophrenics. Schizophr Res 6:9–13

    Article  Google Scholar 

  • Kiehl K, Laurens K, Duty T, Forster B, Liddle P (2001) Neural sources involved in auditory target detection and novelty processing: an event-related fMRI study. Psychophysiology 38:133–142

    Article  PubMed  CAS  Google Scholar 

  • Kileny PR, Kripal JP (1987) Test-retest variability of auditory event-related potentials. Ear Hear 8:110–114

    Article  PubMed  CAS  Google Scholar 

  • Kinoshita S, Inoue M, Maeda H, Nakamura J, Morita K (1996) Long-term patterns of change in ERPs across repeated measurements. Physiol Behav 60:1087–1092

    Article  PubMed  CAS  Google Scholar 

  • Kok A (2001) On the utility of P3 amplitude as a measure of processing capacity. Psychophysiology 38:557–577

    Article  PubMed  CAS  Google Scholar 

  • Kujala T, Kallio J, Tervaniemi M, Näätänen R (2001) The mismatch negativity as an index of temporal processing in audition. Clin Neurophysiol 112:1712–1719

    Article  PubMed  CAS  Google Scholar 

  • Kutas M, McCarthy G, Donchin E (1977) Augmenting mental chronometry: P300 as a measure of stimulus evaluation time. Science 197:792–795

    Article  PubMed  CAS  Google Scholar 

  • Laurent A, Garcia-Larrea L, d’Amato T, Bosson J, Saoud M, Marie-Cardine M, Maugière F, Dalery J (1999) Auditory event-related potentials and clinical scores in unmedicated schizophrenic patients. Psychiatry Res 86:229–238

    Article  PubMed  CAS  Google Scholar 

  • Lavoie S, Murray M, Deppen P, Knyazeva M, Berk M, Boulat O, Bovet P, Bush A, Conus P, Copolov D, Fornari E, Meuli R, Solida A, Vianin P, Cuénod M, Buclin T, Do K (2008) Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients. Neuropsychopharmacology 33:2187–2199

    Article  PubMed  CAS  Google Scholar 

  • Levänen S, Hari R, McEvoy L, Sams M (1993) Responses of the human auditory cortex to changes in one versus two stimulus features. Exp Brain Res 97:177–183

    Article  PubMed  Google Scholar 

  • Light G, Braff D (2005a) Mismatch negativity deficits are associated with poor functioning in schizophrenia patients. Arch Gen Psychiatry 62:127–136

    Article  PubMed  Google Scholar 

  • Light G, Braff D (2005b) Stability of mismatch negativity deficits and their relationship to functional impairments in chronic schizophrenia. Am J Psychiatry 162:1741–1743

    Article  PubMed  Google Scholar 

  • Light G, Williams L, Sprock J, Swerdlow N, Braff D (2010) Electroencephalography (EEG) and event-related potentials (ERP’s) with human participants. Curr Protoc Neurosci (in press)

    Google Scholar 

  • Linden D (2005) The P300: where in the brain is it produced and what does it tell us? Neuroscientist 11:563–576

    Article  PubMed  CAS  Google Scholar 

  • Luck SJ, Woodman GF, Vogel EK (2000) Event-related potential studies of attention. Trends Cogn Sci 4:432–440

    Article  PubMed  Google Scholar 

  • Lyytinen H, Blomberg A, Näätänen R (1992) Event-related potentials and autonomic responses to a change in unattended auditory stimuli. Psychophysiology 29:523–534

    Article  PubMed  CAS  Google Scholar 

  • Makeig S, Westerfield M, Jung TP, Enghoff S, Townsend J, Courchesne E, Sejnowski TJ (2002) Dynamic brain sources of visual evoked responses. Science 295:690–694

    Article  PubMed  CAS  Google Scholar 

  • Makeig S, Debener S, Onton J, Delorme A (2004a) Mining event-related brain dynamics. Trends Cogn Sci 8:204–210

    Article  PubMed  Google Scholar 

  • Makeig S, Delorme A, Westerfield M, Jung T, Townsend J, Courchesne E, Sejnowski T (2004b) Electroencephalographic brain dynamics following manually responded visual targets. PLOS Biol 2:747–762

    Article  CAS  Google Scholar 

  • Mathalon D, Ford J, Pfefferbaum A (2000) Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study. Biol Psychiatry 47:434–449

    Article  PubMed  CAS  Google Scholar 

  • Maxwell C, Liang Y, Weightman B, Kanes S, Abel T, Gur R, Turetsky B, Bilker W, Lenox R, Siegel S (2004) Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential. Neuropsychopharmacology 29:739–746

    Article  PubMed  CAS  Google Scholar 

  • Maxwell C, Ehrlichman R, Liang Y, Gettes D, Evans D, Kanes S, Abel T, Karp J, Siegel S (2006) Corticosterone modulates auditory gating in mouse. Neuropsychopharmacology 31:897–903

    Article  PubMed  CAS  Google Scholar 

  • McCarley R, Faux S, Shenton M, LeMay M, Cane M, Ballinger R, Duffy F (1989) CT abnormalities in schizophrenia. A preliminary study of their correlations with P300/P200 electrophysiological features and positive/negative symptoms. Arch Gen Psychiatry 46:698–708

    Article  PubMed  CAS  Google Scholar 

  • McCarley R, Faux S, Shenton M, Nestor P, Adams J (1991) Event-related potentials in schizophrenia: their biological and clinical correlates and a new model of schizophrenic pathophysiology. Schizophr Res 4:209–231

    Article  PubMed  CAS  Google Scholar 

  • Mertens R, Polich J (1997) P300 from a single-stimulus paradigm: passive versus active tasks and stimulus modality. Electroencephalogr Clin Neurophysiol 104:488–497

    Article  PubMed  CAS  Google Scholar 

  • Michie P, Fox A, Ward P, Catts S, McConaghy N (1990) Event-related potential indices of selective attention and cortical lateralization in schizophrenia. Psychophysiology 27:209–227

    Article  PubMed  CAS  Google Scholar 

  • Michie PT, Budd TW, Todd J, Rock D, Wichmann H, Box J, Jablensky AV (2000) Duration and frequency mismatch negativity in schizophrenia. Clin Neurophysiol 111:1054–1065

    Article  PubMed  CAS  Google Scholar 

  • Michie P, Innes-Brown H, Todd J, Jablensky A (2002) Duration mismatch negativity in biological relatives of patients with schizophrenia spectrum disorders. Biol Psychiatry 52:749–758

    Article  PubMed  Google Scholar 

  • Morlet D, Bouchet P, Fischer C (2000) Mismatch negativity and N100 monitoring: potential clinical value and methodological advances. Audiol Neurootol 5:198–206

    Article  PubMed  CAS  Google Scholar 

  • Näätänen R (1990) The role of attention in auditory information processing as revealed by event-related potentials and other brain measures of cognitive function. Behav Brain Sci 13:201–288

    Article  Google Scholar 

  • Näätänen R (1992) Attention and brain function. Erlbaum, Hillsdale, NJ

    Google Scholar 

  • Näätänen R, Alho K (1997) Mismatch negativity – the measure for central sound representation accuracy. Audiol Neurootol 2:341–353

    Article  PubMed  Google Scholar 

  • Näätänen R, Michie P (1979) Early selective-attention effects on the evoked potential: a critical review and reinterpretation. Biol Psychol 8:81–136

    Article  PubMed  Google Scholar 

  • Näätänen R, Picton T (1987) The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. Psychophysiology 24:375–425

    Article  PubMed  Google Scholar 

  • Näätänen R, Winkler I (1999) The concept of auditory stimulus representation in cognitive neuroscience. Psychol Bull 125:826–859

    Article  PubMed  Google Scholar 

  • Näätänen R, Gaillard A, Mantysalo S (1978) Early selective-attention effect on evoked potential reinterpreted. Acta Psychol (Amst) 42:313–329

    Article  Google Scholar 

  • Näätänen R, Simpson M, Loveless N (1982) Stimulus deviance and evoked potentials. Biol Psychol 14:53–98

    Article  PubMed  Google Scholar 

  • Näätänen R, Paavilainen P, Alho K, Reinikainen K, Sams M (1989a) Do event-related potentials reveal the mechanism of the auditory sensory memory in the human brain? Neurosci Lett 98:217–221

    Article  PubMed  Google Scholar 

  • Näätänen R, Paavilainen P, Reinikainen K (1989b) Do event-related potentials to infrequent decrements in duration of auditory stimuli demonstrate a memory trace in man? Neurosci Lett 107:347–352

    Article  PubMed  Google Scholar 

  • Näätänen R, Tervaniemi M, Sussman E, Paavilainen P, Winkler I (2001) “Primitive intelligence” in the auditory cortex. Trends Neurosci 24:283–288

    Article  PubMed  Google Scholar 

  • Näätänen R, Paavilainen P, Rinne T, Alho K (2007) The mismatch negativity (MMN) in basic research of central auditory processing: a review. Clin Neurophysiol 118:2544–2590

    Article  PubMed  Google Scholar 

  • Nagamoto HT, Adler LE, Waldo MC, Freedman R (1989) Sensory gating in schizophrenics and normal controls: effects of changing stimulation interval. Biol Psychiatry 25:549–561

    Article  PubMed  CAS  Google Scholar 

  • Nashida T, Yabe H, Sato Y, Hiruma T, Sutoh T, Shinozaki N, Kaneko S (2000) Automatic auditory information processing in sleep. Sleep 23:821–828

    PubMed  CAS  Google Scholar 

  • Norman DA (1968) Toward a theory of memory and attention. Psychol Rev 75:522–536

    Article  Google Scholar 

  • O’Donnell BF, Hokama H, McCarley RW, Smith RS, Salisbury DF, Mondrow E, Nestor PG, Shenton ME (1994) Auditory ERPs to non-target stimuli in schizophrenia: relationship to probability, task-demands, and target ERPs. Int J Psychophysiol 17:219–231

    Article  PubMed  Google Scholar 

  • O’Donnell BF, Faux SF, McCarley RW, Kimble MO, Salisbury DF, Nestor PG, Kikinis R, Jolesz FA, Shenton ME (1995) Increased rate of P300 latency prolongation with age in schizophrenia. Electrophysiological evidence for a neurodegenerative process. Arch Gen Psychiatry 52:544–549

    Article  PubMed  Google Scholar 

  • O’Donnell B, McCarley R, Potts G, Salisbury D, Nestor P, Hirayasu Y, Niznikiewicz M, Barnard J, Shen Z, Winstein D, Bookstein DL, Shenton M (1999) Identification of neural circuits underlying P300 abnormalities in schizophrenia. Psychophysiology 36:388–398

    Article  PubMed  Google Scholar 

  • Oades R, Dittmann-Balcar A, Zerbin D, Grzella I (1997) Impaired attention-dependent augmentation of MMN in nonparanoid vs paranoid schizophrenic patients: a comparison with obsessive-compulsive disorder and healthy subjects. Biol Psychiatry 41:1196–1210

    Article  PubMed  CAS  Google Scholar 

  • Ogura C, Nageishi Y, Matsubayashi M, Omura F, Kishimoto A, Shimokochi M (1991) Abnormalities in event-related potentials, N100, P200, P300 and slow wave in schizophrenia. Jpn J Psychiatry Neurol 45:57–65

    PubMed  CAS  Google Scholar 

  • Pakarinen S, Takegata R, Rinne T, Huotilainen M, Näätänen R (2007) Measurement of extensive auditory discrimination profiles using the mismatch negativity (MMN) of the auditory event-related potential (ERP). Clin Neurophysiol 118:177–185

    Article  PubMed  Google Scholar 

  • Parasuraman R, Beatty J (1980) Brain events underlying detection and recognition of weak sensory signals. Science 210:80–83

    Article  PubMed  CAS  Google Scholar 

  • Pass H, Klorman R, Salzman L, Klein R, Kaskey G (1980) The late positive component of the evoked response in acute schizophrenics during a test of sustained attention. Biol Psychiatry 15:9–20

    PubMed  CAS  Google Scholar 

  • Pekkonen E, Rinne T, Näätänen R (1995) Variability and replicability of the mismatch negativity. Electroencephalogr Clin Neurophysiol 96:546–554

    Article  PubMed  CAS  Google Scholar 

  • Pfefferbaum A (1984) Clinical application of the P3 component of event-related potentials: II. Dementia, depression and schizophrenia. Electroencephalogr Clin Neurophysiol 59:104–124

    Article  PubMed  CAS  Google Scholar 

  • Pfefferbaum A, Ford J, White P, Roth W (1989) P3 in schizophrenia is affected by stimulus modality, response requirements, medication status, and negative symptoms. Arch Gen Psychiatry 46:1035–1044

    Article  PubMed  CAS  Google Scholar 

  • Pfefferbaum A, Roth W, Ford J (1995) Event-related potentials in the study of psychiatric disorders. Arch Gen Psychiatry Res 52:559–563

    Article  CAS  Google Scholar 

  • Polich J, Criado J (2006) Neuropsychology and neuropharmacology of P3a and P3b. Int J Psychophysiol 60:172–185

    Article  PubMed  Google Scholar 

  • Pollock VE, Schneider LS (1992) Reliability of late positive component activity (P3) in healthy elderly adults. J Gerontol 47:M88–M92

    Article  PubMed  CAS  Google Scholar 

  • Price GW, Michie PT, Johnston J, Innes-Brown H, Kent A, Clissa P, Jablensky AV (2006) A multivariate electrophysiological endophenotype, from a unitary cohort, shows greater research utility than any single feature in the Western Australian family study of schizophrenia. Biol Psychiatry 60:1–10

    Article  PubMed  Google Scholar 

  • Rao K, Ananthnarayanan C, Gangadhar B, Janakiramaiah N (1995) Smaller auditory P300 amplitude in schizophrenics in remission. Neuropsychobiology 32:171–174

    Article  PubMed  CAS  Google Scholar 

  • Rasser PE, Schall U, Todd J, Michie PT, Ward PB, Johnston P, Helmbold K, Case V, Søyland A, Tooney PA, Thompson PM (2009) Gray matter deficits, mismatch negativity, and outcomes in schizophrenia. Schizophr Bull (Epub ahead of print, June 26)

    Google Scholar 

  • Rentzsch J, Jockers-Scherubl MC, Boutros NN, Gallinat J (2008) Test-retest reliability of P50, N100 and P200 auditory sensory gating in healthy subjects. Int J Psychophysiol 67:81–90

    Article  PubMed  Google Scholar 

  • Rinne T, Alho K, Ilmoniemi R, Virtanen J, Näätänen R (2000) Separate time behaviors of the temporal and frontal mismatch negativity sources. Neuroimage 12:14–19

    Article  PubMed  CAS  Google Scholar 

  • Rinne T, Antila S, Winkler I (2001) Mismatch negativity is unaffected by top-down predictive information. NeuroReport 12:2209–2213

    Article  PubMed  CAS  Google Scholar 

  • Ritter W, Sussman E, Deacon D, Cowan N, Vaughan HG Jr (1999) Two cognitive systems simultaneously prepared for opposite events. Psychophysiology 36:835–838

    Article  PubMed  CAS  Google Scholar 

  • Roberts T, Poeppel D (1996) Latency of auditory evoked M100 as a function of tone frequency. NeuroReport 7:1138–1140

    Article  PubMed  CAS  Google Scholar 

  • Romani A, Merello S, Gozzoli L, Zerbi F, Grassi M, Cosi V (1987) P300 and CT scan in patients with chronic schizophrenia. Br J Psychiatry 151:506–513

    Article  PubMed  CAS  Google Scholar 

  • Roth W, Horvath T, Pfefferbaum A, Kopell B (1980) Event-related potentials in schizophrenics. Electroencephalogr Clin Neurophysiol 48:127–139

    Article  PubMed  CAS  Google Scholar 

  • Roth W, Goodale J, Pfefferbaum A (1991) Auditory event-related potentials and electrodermal activity in medicated and unmedicated schizophrenics. Biol Psychiatry 29:585–599

    Article  PubMed  CAS  Google Scholar 

  • Roxborough H, Muir W, Blackwood D, Walker M, Blackburn I (1993) Neuropsychological and P300 abnormalities in schizophrenics and their relatives. Psychol Med 23:305–314

    Article  PubMed  CAS  Google Scholar 

  • Saitoh O, Niwa S, Hiramatsu K, Kameyama T, Rymar K, Itoh K (1984) Abnormalities in late positive components of event-related potentials may reflect a genetic predisposition to schizophrenia. Biol Psychiatry 19:293–303

    PubMed  CAS  Google Scholar 

  • Salisbury D, Shenton M, Griggs C, Bonner-Jackson A, McCarley R (2002) Mismatch negativity in chronic schizophrenia and first-episode schizophrenia. Arch Gen Psychiatry 59:686–694

    Article  PubMed  Google Scholar 

  • Sandman C, Patterson J (2000) The auditory event-related potential is a stable and reliable measure in elderly subjects over a 3 year period. Clin Neurophysiol 111:1427–1437

    Article  PubMed  CAS  Google Scholar 

  • Schall U, Catts SV, Karayanidis F, Ward PB (1999) Auditory event-related potential indices of fronto-temporal information processing in schizophrenia syndromes: valid outcome prediction of clozapine therapy in a three-year follow-up. Int J Neuropsychopharmacol 2:83–93

    Article  PubMed  Google Scholar 

  • Schreiber H, Stolz-Born G, Kornhuber H, Born J (1992) Event related potential correlates of impaired selective attention in children at high risk for schizophrenia. Biol Psychiatry 32:634–651

    Article  PubMed  CAS  Google Scholar 

  • Schröger E (1997) On the detection of auditory deviations: a pre-attentive activation model. Psychophysiology 34:245–257

    Article  PubMed  Google Scholar 

  • Segalowitz SJ, Barnes KL (1993) The reliability of ERP components in the auditory oddball paradigm. Psychophysiology 30:451–459

    Article  PubMed  CAS  Google Scholar 

  • Sinha R, Bernardy N, Parsons OA (1992) Long-term test-retest reliability of event-related potentials in normals and alcoholics. Biol Psychiatry 32:992–1003

    Article  PubMed  CAS  Google Scholar 

  • Smith M, Halgren E, Sokolik M, Baudena P, Musolino A, Liegeois-Chauvel C, Chauvel P (1990) The intracranial topography of the P3 event-related potential elicited during auditory oddball. Electroencephalogr Clin Neurophysiol 76:235–248

    Article  PubMed  CAS  Google Scholar 

  • Souza VBN, Muir WJ, Walker MT, Glabus MF, Roxborough HM, Sharp CW, Dunan JR, Blackwood DHR (1995) Auditory P300 event-related potentials and neuropsychological performance in schizophrenia and bipolar affective disorder. Biol Psychiatry 37:300–310

    Article  PubMed  CAS  Google Scholar 

  • Spencer K, Dien J, Donchin E (2001) Spatiotemporal analysis of the late ERP responses to deviant stimuli. Psychophysiology 38:343–358

    Article  PubMed  CAS  Google Scholar 

  • Squires NK, Squires KC, Hillyard SA (1975) Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. Electroencephalogr Clin Neurophysiol 38:387–340

    Article  PubMed  CAS  Google Scholar 

  • Strik W, Dierks T, Boning J, Osterheider M, Caspari A, Korber J (1992) Disorders of smooth pursuit eye movement and auditory N100 in schizophrenic patients. Psychiatry Res 41:227–235

    Article  PubMed  CAS  Google Scholar 

  • Strik W, Dierks T, Maurer K (1993) Amplitudes of auditory P300 in remitted and residual schizophrenics: correlations with clinical features. Neuropsychobiology 27:54–60

    Article  PubMed  CAS  Google Scholar 

  • Sumich A, Harris A, Flynn G, Whitford T, Tunstall N, Kumari V, Brammer M, Gordon E, Williams LM (2006) Event-related potential correlates of depression, insight and negative symptoms in males with recent-onset psychosis. Clin Neurophysiol 117:1715–1727

    Article  PubMed  Google Scholar 

  • Sussman E, Winkler I, Wang W (2003) MMN and attention: competition for deviance detection. Psychophysiology 40:430–435

    Article  PubMed  Google Scholar 

  • Swerdlow NR, Geyer MA, Shoemaker JM, Light GA, Braff DL, Stevens KE, Sharp R, Breier M, Neary A, Auerbach PP (2005) Convergence and divergence in the neurochemical regulation of prepulse inhibition of startle and N40 suppression in rats. Neuropsychopharmacology 31:506–515

    Article  CAS  Google Scholar 

  • Tervaniemi M, Lehtokoski A, Sinkkonen J, Virtanen J, Ilmoniemi R, Näätänen R (1999) Test-retest reliability of mismatch negativity for duration, frequency and intensity changes. Clin Neurophysiol 110:1388–1393

    Article  PubMed  CAS  Google Scholar 

  • Tiitinen H, May P, Reinikainen K, Näätänen R (1994) Attentive novelty detection in humans is governed by pre-attentive sensory memory. Nature 372:90–92

    Article  PubMed  CAS  Google Scholar 

  • Todd J, Michie PT, Budd TW, Rock D, Jablensky AV (2000) Auditory sensory memory in schizophrenia: inadequate trace formation? Psychiatry Res 96:99–115

    Article  PubMed  CAS  Google Scholar 

  • Treisman A (1960) Contextual cues in selective listening. Q J Exp Psychol 12:242–248

    Article  Google Scholar 

  • Trejo L, Ryan-Jones D, Kramer A (1995) Attentional modulation of the mismatch negativity elicited by frequency differences between binaurally presented tone bursts. Psychophysiology 32:319–328

    Article  PubMed  CAS  Google Scholar 

  • Turetsky B, Colbath E, Gur R (1998a) P300 subcomponent abnormalities in schizophrenia: I. Physiological evidence for gender and subtype specific differences in regional pathology. Biol Psychiatry 43:84–96

    Article  PubMed  CAS  Google Scholar 

  • Turetsky B, Colbath E, Gur R (1998b) P300 subcomponent abnormalities in schizophrenia: longitudinal stability and relationship to symptom change. Biol Psychiatry 43:31–39

    Article  PubMed  CAS  Google Scholar 

  • Turetsky B, Colbath E, Gur R (2000) P300 subcomponent abnormalities in schizophrenia: III. Deficits in unaffected siblings of schizophrenic probands. Biol Psychiatry 47:380–390

    Article  PubMed  CAS  Google Scholar 

  • Turetsky B, Calkins M, Light G, Olincy A, Radant A, Swerdlow N (2007) Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures. Schizophr Bull 33:69–94

    Article  PubMed  Google Scholar 

  • Turetsky B, Greenwood T, Olincy A, Radant A, Braff D, Cadenhead K, Dobie D, Freedman R, Green M, Gur R, Gur R, Light G, Mintz J, Nuechterlein K, Schork N, Seidman L, Siever L, Silverman J, Stone W, Swerdlow N, Tsuang D, Tsuang M, Calkins M (2008) Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands. Biol Psychiatry 64:1051–1059

    Article  PubMed  Google Scholar 

  • Umbricht D, Krljes S (2005) Mismatch negativity in schizophrenia: a meta-analysis. Schizophr Res 76:1–23

    Article  PubMed  Google Scholar 

  • Umbricht D, Koller R, Schmid L, Skrabo A, Grübel C, Huber T, Stassen H (2003) How specific are deficits in mismatch negativity generation to schizophrenia? Biol Psychiatry 53:1120–1131

    Article  PubMed  Google Scholar 

  • Umbricht D, Bates J, Lieberman J, Kane J, Javitt D (2006) Electrophysiological indices of automatic and controlled auditory information processing in first-episode, recent-onset and chronic schizophrenia. Biol Psychiatry 59:762–772

    Article  PubMed  Google Scholar 

  • van der Stelt O, Gunning W, Snel J, Kok A (1997) No electrocortical evidence of automatic mismatch dysfunction in children of alcoholics. Alcohol Clin Exp Res 21:569–575

    Article  PubMed  Google Scholar 

  • Vaughan H, Ritter W (1970) The sources of auditory evoked responses recorded from the human scalp. Electroencephalogr Clin Neurophysiol 28:360–367

    Article  PubMed  Google Scholar 

  • Waberski TD, Kreitschmann-Andermahr I, Kawohl W, Darvas F, Ryang Y, Gobbele R, Buchner H (2001) Spatio-temporal source imaging reveals subcomponents of the human auditory mismatch negativity in the cingulum and right inferior temporal gyrus. Neurosci Lett 308:107–110

    Article  PubMed  CAS  Google Scholar 

  • Waldo M, Adler LE, Freedman R (1988) Defects in auditory sensory gating and their apparent compensation in relatives of schizophrenics. Schizophr Res 1:19–24

    Article  PubMed  CAS  Google Scholar 

  • Weisbrod M, Hill H, Niethammer R, Sauer H (1999) Genetic influence on auditory information processing in schizophrenia: P300 in monozygotic twins. Biol Psychiatry 46:721–725

    Article  PubMed  CAS  Google Scholar 

  • Winkler I, Czigler I (1998) Mismatch negativity: deviance detection or the maintenance of the standard. NeuroReport 9:3809

    Article  PubMed  CAS  Google Scholar 

  • Winkler I, Karmos G, Näätänen R (1996) Adaptive modeling of the unattended acoustic environment reflected in the mismatch negativity event-related potential. Brain Res 742:239–252

    Article  PubMed  CAS  Google Scholar 

  • Winterer G, Egan M, Radler T, Coppola R, Weinberger D (2001) Event-related potentials and genetic risk for schizophrenia. Biol Psychiatry 50:407–417

    Article  PubMed  CAS  Google Scholar 

  • Woldorff MG, Hillyard SA (1991) Modulation of early auditory processing during selective listening to rapidly presented tones. Electroencephalogr Clin Neurophysiol 79:170–91

    Google Scholar 

  • Wronka E, Kuniecki M, Kaiser J, Coenen A (2007) The P3 produced by auditory stimuli presented in a passive and active condition: modulation by visual stimuli. Acta Neurobiol Exp 67:155–164

    Google Scholar 

  • Wynn J, Sugar C, Horan W, Kern R, Green M (2010) Mismatch negativity, social cognition, and functioning in schizophrenia patients. Biol Psychiatry (Epub ahead of print, Jan 13)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, University of California, San Diego, CA, USA

    Anthony J. Rissling & Gregory A. Light

Authors
  1. Anthony J. Rissling
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gregory A. Light
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gregory A. Light .

Editor information

Editors and Affiliations

  1. , Dept. of Psychiatry - MC 0804, University of San Diego, Gilman Drive 9500, La Jolla, 92093, USA

    Neal R. Swerdlow

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Rissling, A.J., Light, G.A. (2010). Neurophysiological Measures of Sensory Registration, Stimulus Discrimination, and Selection in Schizophrenia Patients. In: Swerdlow, N. (eds) Behavioral Neurobiology of Schizophrenia and Its Treatment. Current Topics in Behavioral Neurosciences, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2010_59

Download citation

Publish with us

Policies and ethics

Search

Navigation