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Molecular and Functional Models in Neuropsychiatry pp 359–383Cite as

The Pig as a Model Animal for Studying Cognition and Neurobehavioral Disorders

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 7))

Abstract

In experimental animal research, a short phylogenetic distance, i.e., high resemblance between the model species and the species to be modeled is expected to increase the relevance and generalizability of results obtained in the model species. The (mini)pig shows multiple advantageous characteristics that have led to an increase in the use of this species in studies modeling human medical issues, including neurobehavioral (dys)functions. For example, the cerebral cortex of pigs, unlike that of mice or rats, has cerebral convolutions (gyri and sulci) similar to the human neocortex. We expect that appropriately chosen pig models will yield results of high translational value. However, this claim still needs to be substantiated by research, and the area of pig research is still in its infancy. This chapter provides an overview of the pig as a model species for studying cognitive dysfunctions and neurobehavioral disorders and their treatment, along with a discussion of the pros and cons of various tests, as an aid to researchers considering the use of pigs as model animal species in biomedical research.

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Abbreviations

ADME:

Absorption, distribution, metabolism, and excretion

APPsw:

Amyloid precursor protein, Swedish mutation

CNS:

Central nervous system

CS:

Conditioned stimulus

HCA:

Hypothermic circulatory arrest

HPA:

Hypothalamic–pituitary–adrenal

MR:

Magnetic resonance

MRI:

Magnetic resonance imaging

ORT:

Object recognition test

PET:

Positron emission tomography

RNA:

Ribonucleic acid

US:

Unconditioned stimulus

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Authors and Affiliations

  1. Program ‘Emotion and Cognition’, Department of Farm Animal Health, Veterinary Faculty, Utrecht University, 80166, Utrecht, 3508 TD, The Netherlands

    Elise T. Gieling, Rebecca E. Nordquist & F. Josef van der Staay

  2. Rudolf Magnus Institute of Neuroscience, Universiteitsweg 100, Utrecht, 3584 CG, The Netherlands

    Elise T. Gieling, Rebecca E. Nordquist & F. Josef van der Staay

  3. BioMedical Research, Wageningen University and Research Center, 65, Lelystad, 8200 AB, The Netherlands

    Teun Schuurman

Authors
  1. Elise T. Gieling
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  2. Teun Schuurman
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  3. Rebecca E. Nordquist
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  4. F. Josef van der Staay
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Corresponding author

Correspondence to Teun Schuurman .

Editor information

Editors and Affiliations

  1. Global Medical Excellence Cluster (GMEC), King's College London, London, SE1 1UL, United Kingdom

    Jim J. Hagan

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Gieling, E.T., Schuurman, T., Nordquist, R.E., van der Staay, F.J. (2011). The Pig as a Model Animal for Studying Cognition and Neurobehavioral Disorders. In: Hagan, J. (eds) Molecular and Functional Models in Neuropsychiatry. Current Topics in Behavioral Neurosciences, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2010_112

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