Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- AGE:
-
advanced glycation end products
- BMDC:
-
bone marrow-derived dendritic cells
- CBP:
-
CREB binding protein
- COPD:
-
chronic obstructive pulmonary disease
- CSF:
-
cerebrospinal fluid
- DRD2:
-
dopamine D2 receptors
- DSS:
-
dextran sodium sulfate
- EAU:
-
experimental autoimmune uveitis
- EMT:
-
epithelial to mesenchymal transition
- GBS:
-
Guillain-Barre syndrome
- HCC:
-
hepatocellular carcinoma
- HERC:
-
human retinal endothelial cells
- HSP:
-
heat shock proteins
- IBD:
-
inflammatory bowel disease
- IDO:
-
indoleamine 2,3-dioxygenase
- IL:
-
interleukin
- iNOS:
-
inducible nitric oxide synthase
- IPF:
-
idiopathic pulmonary fibrosis
- LPS:
-
lipopolysaccharide
- MAPK:
-
mitogen-activated protein kinase
- MAPKAPK-2:
-
mitogen-activated protein kinase (MAPK)-activated protein kinase 2
- MARCO:
-
macrophage scavenger receptor with collagenous structure
- MCRA:
-
macrophage scavenger receptor A
- MKBP:
-
myotonic dystrophy protein kinase
- NBD:
-
Neuro-Behçet’s disease
- ODF1:
-
outer dense fiber protein 1
- PGE2:
-
prostaglandin E2
- PLGA:
-
poly (lactic-co-glycolic acid)
- ROS:
-
reactive oxygen species
- sHsp:
-
small heat shock proteins
- SR-A:
-
scavenger receptor-A
- STZ:
-
streptozotocin
- TLRs:
-
toll like receptors
- TNFα:
-
tumor necrosis factor-α
- UUO:
-
unilateral ureteral obstruction
- αAC:
-
alpha A crystallin
- αBC:
-
alpha B crystallin
References
Ahmad MF, Singh D, Taiyab A, Ramakrishna T, Raman B, Rao Ch M (2008) Selective Cu2+ binding, redox silencing, and cytoprotective effects of the small heat shock proteins alphaA- and alphaB-crystallin. J Mol Biol 382:812–824
Aoyama A, Steiger RH, Frohli E, Schafer R, von Deimling A, Wiestler OD, Klemenz R (1993) Expression of alpha B-crystallin in human brain tumors. Int J Cancer/Journal International du Cancer 55:760–764
Arac A, Brownell SE, Rothbard JB, Chen C, Ko RM, Pereira MP, Albers GW, Steinman L, Steinberg GK (2011) Systemic augmentation of alphaB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation. Proc Natl Acad Sci U S A 108:13287–13292
Arrigo AP (2013) Human small heat shock proteins: protein interactomes of homo- and hetero-oligomeric complexes: an update. FEBS Lett 587:1959–1969
Bajramovic JJ, Lassmann H, van Noort JM (1997) Expression of alphaB-crystallin in glia cells during lesional development in multiple sclerosis. J Neuroimmunol 78:143–151
Bajramovic JJ, Plomp AC, Goes A, Koevoets C, Newcombe J, Cuzner ML, van Noort JM (2000) Presentation of alpha B-crystallin to T cells in active multiple sclerosis lesions: an early event following inflammatory demyelination. J Immunol 164:4359–4366
Bakthisaran R, Tangirala R, Rao Ch M (2015) Small heat shock proteins: role in cellular functions and pathology. Biochim Biophys Acta 1854:291–319
Banathy A, Cheung-Flynn J, Goleniewska K, Boyd KL, Newcomb DC, Peebles RS Jr, Komalavilas P (2016) Heat shock-related protein 20 peptide decreases human airway constriction downstream of beta2-adrenergic receptor. Am J Respir Cell Mol Biol 55:225–233
Banerjee S, Lin CF, Skinner KA, Schiffhauer LM, Peacock J, Hicks DG, Redmond EM, Morrow D, Huston A, Shayne M, Langstein HN, Miller-Graziano CL, Strickland J, O’Donoghue L, De AK (2011) Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression. Cancer Res 71:318–327
Barutta F, Pinach S, Giunti S, Vittone F, Forbes JM, Chiarle R, Arnstein M, Perin PC, Camussi G, Cooper ME, Gruden G (2008) Heat shock protein expression in diabetic nephropathy. Am J Physiol Renal Physiol 295:F1817–F1824
Bellaye PS, Burgy O, Causse S, Garrido C, Bonniaud P (2014a) Heat shock proteins in fibrosis and wound healing: good or evil? Pharmacol Ther 143:119–132
Bellaye PS, Burgy O, Colas J, Fabre A, Marchal-Somme J, Crestani B, Kolb M, Camus P, Garrido C, Bonniaud P (2014b) Anti-fibrotic role of alphaB-crystallin inhibition in pleural and subpleural fibrosis. Am J Respir Cell Mol Biol
Bellaye PS, Wettstein G, Burgy O, Besnard V, Joannes A, Colas J, Causse S, Marchal-Somme J, Fabre A, Crestani B, Kolb M, Gauldie J, Camus P, Garrido C, Bonniaud P (2014c) The small heat-shock protein alphaB-crystallin is essential for the nuclear localization of Smad4: impact on pulmonary fibrosis. J Pathol 232:458–472
Bhat SP, Gangalum RK (2011) Secretion of alphaB-Crystallin via exosomes: new clues to the function of human retinal pigment epithelium. Commun Integr Biol 4:739–741
Bhattacharyya J, Padmanabha Udupa EG, Wang J, Sharma KK (2006) Mini-alphaB-crystallin: a functional element of alphaB-crystallin with chaperone-like activity. Biochemistry 45:3069–3076
Bhattacharyya S, Dudeja PK, Tobacman JK (2009) ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8. Inflamm Bowel Dis 15:673–683
Bi X, Jiang B, Zhou J, Luo L, Yin Z (2019) Phosphorylated Hsp27 prevents LPS-induced excessive inflammation in THP-1 cells via suppressing ROS-mediated upregulation of CBP. Cell Biol Int
Bonniaud P, Bellaye PS, Burgy O, Kolb M (2017) Heat shock protein: a hot topic in idiopathic pulmonary fibrosis. Eur Respir J 49
Brownell SE, Becker RA, Steinman L (2012) The protective and therapeutic function of small heat shock proteins in neurological diseases. Front Immunol 3:74
Burut DF, Borai A, Livingstone C, Ferns G (2010) Serum heat shock protein 27 antigen and antibody levels appear to be related to the macrovascular complications associated with insulin resistance: a pilot study. Cell Stress Chaperones 15:379–386
Carra S, Seguin SJ, Landry J (2008) HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy. Autophagy 4:237–239
Carra S, Alberti S, Arrigo PA, Benesch JL, Benjamin IJ, Boelens W, Bartelt-Kirbach B, Brundel B, Buchner J, Bukau B, Carver JA, Ecroyd H, Emanuelsson C, Finet S, Golenhofen N, Goloubinoff P, Gusev N, Haslbeck M, Hightower LE, Kampinga HH, Klevit RE, Liberek K, McHaourab HS, McMenimen KA, Poletti A, Quinlan R, Strelkov SV, Toth ME, Vierling E, Tanguay RM (2017) The growing world of small heat shock proteins: from structure to functions. Cell Stress Chaperones 22:601–611
Carra S, Alberti S, Benesch JLP, Boelens W, Buchner J, Carver JA, Cecconi C, Ecroyd H, Gusev N, Hightower LE, Klevit RE, Lee HO, Liberek K, Lockwood B, Poletti A, Timmerman V, Toth ME, Vierling E, Wu T, Tanguay RM (2019) Small heat shock proteins: multifaceted proteins with important implications for life. Cell Stress Chaperones 24:295–308
Ce P, Erkizan O, Gedizlioglu M (2011) Elevated HSP27 levels during attacks in patients with multiple sclerosis. Acta Neurol Scand 124:317–320
Celet B, Akman-Demir G, Serdaroglu P, Yentur SP, Tasci B, van Noort JM, Eraksoy M, Saruhan-Direskeneli G (2000) Anti-alpha B-crystallin immunoreactivity in inflammatory nervous system diseases. J Neurol 247:935–939
Charmpilas N, Kyriakakis E, Tavernarakis N (2017) Small heat shock proteins in ageing and age-related diseases. Cell Stress Chaperones 22:481–492
Chatterjee S, Burns TF (2017) Targeting heat shock proteins in cancer: a promising therapeutic approach. Int J Mol Sci 18
Chen D, Cao G, Qiao C, Liu G, Zhou H, Liu Q (2018) Alpha B-crystallin promotes the invasion and metastasis of gastric cancer via NF-kappaB-induced epithelial-mesenchymal transition. J Cell Mol Med 22:3215–3222
Chen QQ, Haikal C, Li W, Li JY (2019) Gut inflammation in association with pathogenesis of Parkinson’s disease. Front Mol Neurosci 12:218
Cherneva RV, Georgiev OB, Petrova DS, Trifonova NL, Stamenova M, Ivanova V, Vlasov VI (2012) The role of small heat-shock protein alphaB-crystalline (HspB5) in COPD pathogenesis. Int J Chron Obstruct Pulmon Dis 7:633–640
Crowe J, Aubareda A, McNamee K, Przybycien PM, Lu X, Williams RO, Bou-Gharios G, Saklatvala J, Dean JL (2013) Heat shock protein B1-deficient mice display impaired wound healing. PLoS One 8:e77383
Cuerrier CM, Chen YX, Tremblay D, Rayner K, McNulty M, Zhao X, Kennedy CR, de BelleRoche J, Pelling AE, O’Brien ER (2013) Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions. PLoS One 8:e55867
de Jong WW, Leunissen JA, Voorter CE (1993) Evolution of the alpha-crystallin/small heat-shock protein family. Mol Biol Evol 10:103–126
den Engelsman J, Keijsers V, de Jong WW, Boelens WC (2003) The small heat-shock protein alpha B-crystallin promotes FBX4-dependent ubiquitination. J Biol Chem 278:4699–4704
Dong Z, Kase S, Ando R, Fukuhara J, Saito W, Kanda A, Murata M, Noda K, Ishida S (2012) Alphab-crystallin expression in epiretinal membrane of human proliferative diabetic retinopathy. Retina 32:1190–1196
Dukay B, Csoboz B, Toth ME (2019) Heat-shock proteins in neuroinflammation. Front Pharmacol 10:920
Erni ST, Fernandes G, Buri M, Perny M, Rutten RJ, van Noort JM, Senn P, Grandgirard D, Roccio M, Leib SL (2019) Anti-inflammatory and Oto-protective effect of the small heat shock protein alpha B-Crystallin (HspB5) in experimental pneumococcal meningitis. Front Neurol 10:570
Feng JT, Liu YK, Song HY, Dai Z, Qin LX, Almofti MR, Fang CY, Lu HJ, Yang PY, Tang ZY (2005) Heat-shock protein 27: a potential biomarker for hepatocellular carcinoma identified by serum proteome analysis. Proteomics 5:4581–4588
Gangalum RK, Bhat AM, Kohan SA, Bhat SP (2016) Inhibition of the expression of the small heat shock protein alphaB-Crystallin inhibits exosome secretion in human retinal pigment epithelial cells in culture. J Biol Chem 291:12930–12942
Garrido C, Paul C, Seigneuric R, Kampinga HH (2012) The small heat shock proteins family: the long forgotten chaperones. Int J Biochem Cell Biol 44:1588–1592
Ghaoui R, Palmio J, Brewer J, Lek M, Needham M, Evila A, Hackman P, Jonson PH, Penttila S, Vihola A, Huovinen S, Lindfors M, Davis RL, Waddell L, Kaur S, Yiannikas C, North K, Clarke N, MacArthur DG, Sue CM, Udd B (2016) Mutations in HSPB8 causing a new phenotype of distal myopathy and motor neuropathy. Neurology 86:391–398
Gorter RP, Nutma E, Jahrei MC, de Jonge JC, Quinlan RA, van der Valk P, van Noort JM, Baron W, Amor S (2018) Heat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis. Clin Exp Immunol 194:137–152
Gruden G, Bruno G, Chaturvedi N, Burt D, Schalkwijk C, Pinach S, Stehouwer CD, Witte DR, Fuller JH, Perin PC (2008) Serum heat shock protein 27 and diabetes complications in the EURODIAB prospective complications study: a novel circulating marker for diabetic neuropathy. Diabetes 57:1966–1970
Guo YS, Liang PZ, Lu SZ, Chen R, Yin YQ, Zhou JW (2019a) Extracellular alphaB-crystallin modulates the inflammatory responses. Biochem Biophys Res Commun 508:282–288
Guo Z, Song J, Hao J, Zhao H, Du X, Li E, Kuang Y, Yang F, Wang W, Deng J, Wang Q (2019b) M2 macrophages promote NSCLC metastasis by upregulating CRYAB. Cell Death Dis 10:377
Hacker S, Lambers C, Hoetzenecker K, Pollreisz A, Aigner C, Lichtenauer M, Mangold A, Niederpold T, Zimmermann M, Taghavi S, Klepetko W, Ankersmit HJ (2009) Elevated HSP27, HSP70 and HSP90 alpha in chronic obstructive pulmonary disease: markers for immune activation and tissue destruction. Clin Lab 55:31–40
Hadadi E, Zhang B, Baidzajevas K, Yusof N, Puan KJ, Ong SM, Yeap WH, Rotzschke O, Kiss-Toth E, Wilson H, Wong SC (2016) Differential IL-1beta secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability. Sci Rep 6:39035
Haslbeck M (2002) sHsp and their role in the chaperone network. Cell Mol Life Sci 59:1649–1657
Haslbeck M, Weinkauf S, Buchner J (2019) Small heat shock proteins: simplicity meets complexity. J Biol Chem 294:2121–2132
He K, Xia L, Zhang J (2018) LPS ameliorates renal ischemia/reperfusion injury via Hsp27 up-regulation. Int Urol Nephrol 50:571–580
Hedhli N, Wang L, Wang Q, Rashed E, Tian Y, Sui X, Madura K, Depre C (2008) Proteasome activation during cardiac hypertrophy by the chaperone H11 kinase/Hsp22. Cardiovasc Res 77:497–505
Hegen H, Wanschitz J, Ehling R, Deisenhammer F, Loscher WN, Reindl M, Berger T (2010) Anti-alpha B-crystallin immunoreactivity in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy. J Peripheral Nervous Syst: JPNS 15:150–152
Heise EA, Marozas LM, Grafton SA, Green KM, Kirwin SJ, Fort PE (2013) Strain-independent increases of crystallin proteins in the retina of type 1 diabetic rats. PLoS One 8:e82520
Ho PY, Chueh SC, Chiou SH, Wang SM, Lin WC, Lee IL, Yang HY, Peng HC, Lai MK (2013) AlphaB-crystallin in clear cell renal cell carcinoma: tumor progression and prognostic significance. Urol Oncol 31:1367–1377
Holcakova J, Hernychova L, Bouchal P, Brozkova K, Zaloudik J, Valik D, Nenutil R, Vojtesek B (2008) Identification of alphaB-crystallin, a biomarker of renal cell carcinoma by SELDI-TOF MS. Int J Biol Markers 23:48–53
Horwitz J (1992) Alpha-crystallin can function as a molecular chaperone. Proc Natl Acad Sci U S A 89:10449–10453
Hu X, Van Marion DMS, Wiersma M, Zhang D, Brundel B (2017) The protective role of small heat shock proteins in cardiac diseases: key role in atrial fibrillation. Cell Stress Chaperones 22:665–674
Huang XY, Ke AW, Shi GM, Zhang X, Zhang C, Shi YH, Wang XY, Ding ZB, Xiao YS, Yan J, Qiu SJ, Fan J, Zhou J (2013) alphaB-crystallin complexes with 14-3-3zeta to induce epithelial-mesenchymal transition and resistance to sorafenib in hepatocellular carcinoma. Hepatology 57:2235–2247
Ishikawa K, Sreekumar PG, Spee C, Nazari H, Zhu D, Kannan R, Hinton DR (2016) alphaB-Crystallin regulates subretinal fibrosis by modulation of epithelial-mesenchymal transition. Am J Pathol 186:859–873
Iwaki T, Iwaki A, Miyazono M, Goldman JE (1991) Preferential expression of alpha B-crystallin in astrocytic elements of neuroectodermal tumors. Cancer 68:2230–2240
Iwaki T, Wisniewski T, Iwaki A, Corbin E, Tomokane N, Tateishi J, Goldman JE (1992) Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions. Am J Pathol 140:345–356
Jakhotia S, Sivaprasad M, Shalini T, Reddy PY, Viswanath K, Jakhotia K, Sahay R, Sahay M, Reddy GB (2018) Circulating levels of Hsp27 in microvascular complications of diabetes: prospects as a biomarker of diabetic nephropathy. J Diabetes Complicat 32:221–225
Jan Ankersmit H, Nickl S, Hoeltl E, Toepker M, Lambers C, Mitterbauer A, Kortuem B, Zimmermann M, Moser B, Bekos C, Steinlechner B, Hofbauer H, Klepetko W, Schenk P, Dome B (2012) Increased serum levels of HSP27 as a marker for incipient chronic obstructive pulmonary disease in young smokers. Respiration 83:391–399
Janik S, Schiefer AI, Bekos C, Hacker P, Haider T, Moser J, Klepetko W, Mullauer L, Ankersmit HJ, Moser B (2016) HSP27 and 70 expression in thymic epithelial tumors and benign thymic alterations: diagnostic, prognostic and physiologic implications. Sci Rep 6:24267
Janowska MK, Baughman HER, Woods CN, Klevit RE (2019) Mechanisms of small heat shock proteins. Cold Spring Harb Perspect Biol 11
Jin C, Cleveland JC, Ao L, Li J, Zeng Q, Fullerton DA, Meng X (2014) Human myocardium releases heat shock protein 27 (HSP27) after global ischemia: the proinflammatory effect of extracellular HSP27 through toll-like receptor (TLR)-2 and TLR4. Mol Med 20:280–289
Kappe G, Franck E, Verschuure P, Boelens WC, Leunissen JA, de Jong WW (2003) The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10. Cell Stress Chaperones 8:53–61
Kase S, Ishida S, Rao NA (2011) Increased expression of alphaA-crystallin in human diabetic eye. Int J Mol Med 28:505–511
Kase S, Meghpara BB, Ishida S, Rao NA (2012) Expression of alpha-crystallin in the retina of human sympathetic ophthalmia. Mol Med Rep 5:395–399
Keijzer C, Wieten L, van Herwijnen M, van der Zee R, Van Eden W, Broere F (2012) Heat shock proteins are therapeutic targets in autoimmune diseases and other chronic inflammatory conditions. Expert Opin Ther Targets 16:849–857
Kim H, Moon C, Ahn M, Byun J, Lee Y, Kim MD, Matsumoto Y, Koh CS, Shin T (2009) Heat shock protein 27 upregulation and phosphorylation in rat experimental autoimmune encephalomyelitis. Brain Res 1304:155–163
Kim YH, Park SY, Park J, Kim YS, Hwang EM, Park JY, Roh GS, Kim HJ, Kang SS, Cho GJ, Choi WS (2012) Reduction of experimental diabetic vascular leakage and pericyte apoptosis in mice by delivery of alphaA-crystallin with a recombinant adenovirus. Diabetologia 55:2835–2844
Klopstein A, Santos-Nogueira E, Francos-Quijorna I, Redensek A, David S, Navarro X, Lopez-Vales R (2012) Beneficial effects of alphaB-Crystallin in spinal cord contusion injury. J Neurosci Off J Soc Neurosci 32:14478–14488
Korfei M, Schmitt S, Ruppert C, Henneke I, Markart P, Loeh B, Mahavadi P, Wygrecka M, Klepetko W, Fink L, Bonniaud P, Preissner KT, Lochnit G, Schaefer L, Seeger W, Guenther A (2011) Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs. J Proteome Res 10:2185–2205
Kostenko S, Moens U (2009) Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology. Cell Mol Life Sci 66:3289–3307
Kourtis N, Tavernarakis N (2018) Small heat shock proteins and neurodegeneration: recent developments. Biomol Concepts 9:94–102
Kriehuber T, Rattei T, Weinmaier T, Bepperling A, Haslbeck M, Buchner J (2010) Independent evolution of the core domain and its flanking sequences in small heat shock proteins. FASEB J 24:3633–3642
Kuipers HF, Yoon J, van Horssen J, Han MH, Bollyky PL, Palmer TD, Steinman L (2017) Phosphorylation of alphaB-crystallin supports reactive astrogliosis in demyelination. Proc Natl Acad Sci U S A 114:E1745–E1754
Kumar PA, Kumar MS, Reddy GB (2007) Effect of glycation on alpha-crystallin structure and chaperone-like function. Biochem J 408:251–258
Kurnellas MP, Brownell SE, Su L, Malkovskiy AV, Rajadas J, Dolganov G, Chopra S, Schoolnik GK, Sobel RA, Webster J, Ousman SS, Becker RA, Steinman L, Rothbard JB (2012) Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis. J Biol Chem 287:36423–36434
Kurnellas MP, Adams CM, Sobel RA, Steinman L, Rothbard JB (2013) Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation. Sci Transl Med 5:179ra142
Landry J, Lambert H, Zhou M, Lavoie JN, Hickey E, Weber LA, Anderson CW (1992) Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J Biol Chem 267:794–803
Lang A, Schrum LW, Schoonhoven R, Tuvia S, Solis-Herruzo JA, Tsukamoto H, Brenner DA, Rippe RA (2000) Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Am J Physiol Gastrointest Liver Physiol 279:G1333–G1342
Lehr S, Hartwig S, Lamers D, Famulla S, Muller S, Hanisch FG, Cuvelier C, Ruige J, Eckardt K, Ouwens DM, Sell H, Eckel J (2012) Identification and validation of novel adipokines released from primary human adipocytes. Mol Cell Proteomics: MCP 11(M111):010504
Li C, Wu J, Li Y, Xing G (2017) Cytoprotective effect of heat shock protein 27 against lipopolysaccharide-induced apoptosis of renal epithelial HK-2 cells. Cell Physiol Biochem 41:2211–2220
Li J, Qi X, Jiang B, Huang T, Luo L, Liu S, Yin Z (2019) Phosphorylated heat shock protein 27 inhibits lipopolysaccharide-induced inflammation in Thp1 cells by promoting TLR4 endocytosis, ubiquitination, and degradation. Inflammation 42:1788–1799
Liao WC, Wu MS, Wang HP, Tien YW, Lin JT (2009) Serum heat shock protein 27 is increased in chronic pancreatitis and pancreatic carcinoma. Pancreas 38:422–426
Litt M, Kramer P, LaMorticella DM, Murphey W, Lovrien EW, Weleber RG (1998) Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA. Hum Mol Genet 7:471–474
Losiewicz MK, Fort PE (2011) Diabetes impairs the neuroprotective properties of retinal alpha-crystallins. Invest Ophthalmol Vis Sci 52:5034–5042
Martine P, Rebe C (2019) Heat shock proteins and inflammasomes. Int J Mol Sci 20
Martin-Ventura JL, Duran MC, Blanco-Colio LM, Meilhac O, Leclercq A, Michel JB, Jensen ON, Hernandez-Merida S, Tunon J, Vivanco F, Egido J (2004) Identification by a differential proteomic approach of heat shock protein 27 as a potential marker of atherosclerosis. Circulation 110:2216–2219
Masilamoni JG, Jesudason EP, Bharathi SN, Jayakumar R (2005a) The protective effect of alpha-crystallin against acute inflammation in mice. Biochim Biophys Acta 1740:411–420
Masilamoni JG, Vignesh S, Kirubagaran R, Jesudason EP, Jayakumar R (2005b) The neuroprotective efficacy of alpha-crystallin against acute inflammation in mice. Brain Res Bull 67:235–241
Masilamoni JG, Jesudason EP, Baben B, Jebaraj CE, Dhandayuthapani S, Jayakumar R (2006) Molecular chaperone alpha-crystallin prevents detrimental effects of neuroinflammation. Biochim Biophys Acta 1762:284–293
Mogk A, Ruger-Herreros C, Bukau B (2019) Cellular functions and mechanisms of action of small heat shock proteins. Annu Rev Microbiol 73:89–110
Nagaraj RH, Nahomi RB, Mueller NH, Raghavan CT, Ammar DA, Petrash JM (2016) Therapeutic potential of alpha-crystallin. Biochim Biophys Acta 1860:252–257
Nagasawa T, Matsushima-Nishiwaki R, Yasuda E, Matsuura J, Toyoda H, Kaneoka Y, Kumada T, Kozawa O (2015) Heat shock protein 20 (HSPB6) regulates TNF-alpha-induced intracellular signaling pathway in human hepatocellular carcinoma cells. Arch Biochem Biophys 565:1–8
Nahomi RB, Wang B, Raghavan CT, Voss O, Doseff AI, Santhoshkumar P, Nagaraj RH (2013) Chaperone peptides of alpha-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts. J Biol Chem 288:13022–13035
Okuno M, Yasuda I, Adachi S, Nakashima M, Kawaguchi J, Doi S, Iwashita T, Hirose Y, Kozawa O, Yoshimi N, Shimizu M, Moriwaki H (2016) The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer. Oncotarget 7:14291–14299
Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O’Connor KC, Hafler DA, Sobel RA, Robinson WH, Steinman L (2007) Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature 448:474–479
Pangratz-Fuehrer S, Kaur K, Ousman SS, Steinman L, Liao YJ (2011) Functional rescue of experimental ischemic optic neuropathy with alphaB-crystallin. Eye (Lond) 25:809–817
Park HK, Park EC, Bae SW, Park MY, Kim SW, Yoo HS, Tudev M, Ko YH, Choi YH, Kim S, Kim DI, Kim YW, Lee BB, Yoon JB, Park JE (2006) Expression of heat shock protein 27 in human atherosclerotic plaques and increased plasma level of heat shock protein 27 in patients with acute coronary syndrome. Circulation 114:886–893
Park AM, Kanai K, Itoh T, Sato T, Tsukui T, Inagaki Y, Selman M, Matsushima K, Yoshie O (2016) Heat shock protein 27 plays a pivotal role in myofibroblast differentiation and in the development of Bleomycin-induced pulmonary fibrosis. PLoS One 11:e0148998
Peng J, Li Y, Wang X, Deng S, Holland J, Yates E, Chen J, Gu H, Essandoh K, Mu X, Wang B, McNamara RK, Peng T, Jegga AG, Liu T, Nakamura T, Huang K, Perez-Tilve D, Fan GC (2018) An Hsp20-FBXO4 Axis regulates adipocyte function through modulating PPARgamma ubiquitination. Cell Rep 23:3607–3620
Pineda R 2nd, Chan CC, Ni M, Hayden BJ, Johnson MA, Nickerson J, Chader GJ (1993) Human retinoblastoma cells express alpha B-crystallin in vivo and in vitro. Curr Eye Res 12:239–245
Ramirez-Rodriguez G, Babu H, Klempin F, Krylyshkina O, Baekelandt V, Gijsbers R, Debyser Z, Overall RW, Nicola Z, Fabel K, Kempermann G (2013) The alpha crystallin domain of small heat shock protein b8 (Hspb8) acts as survival and differentiation factor in adult hippocampal neurogenesis. J Neurosci Off J Soc Neurosci 33:5785–5796
Rao NA, Saraswathy S, Wu GS, Katselis GS, Wawrousek EF, Bhat S (2008) Elevated retina-specific expression of the small heat shock protein, alphaA-crystallin, is associated with photoreceptor protection in experimental uveitis. Invest Ophthalmol Vis Sci 49:1161–1171
Rao NA, Saraswathy S, Pararajasegaram G, Bhat SP (2012) Small heat shock protein alphaA-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis. PLoS One 7:e33582
Raska M, Weigl E (2005) Heat shock proteins in autoimmune diseases. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 149:243–249
Rayner K, Chen YX, McNulty M, Simard T, Zhao X, Wells DJ, de Belleroche J, O’Brien ER (2008) Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-a. Circ Res 103:133–141
Reddy VS, Reddy GB (2015) Emerging role for alphaB-crystallin as a therapeutic agent: pros and cons. Curr Mol Med 15:47–61
Reddy GB, Kumar PA, Kumar MS (2006) Chaperone-like activity and hydrophobicity of alpha-crystallin. IUBMB Life 58:632–641
Reddy VS, Raghu G, Reddy SS, Pasupulati AK, Suryanarayana P, Reddy GB (2013) Response of small heat shock proteins in diabetic rat retina. Invest Ophthalmol Vis Sci 54:7674–7682
Reddy VS, Kumar CU, Raghu G, Reddy GB (2014a) Expression and induction of small heat shock proteins in rat heart under chronic hyperglycemic conditions. Arch Biochem Biophys 558C:1–9
Reddy VS, Kumar CU, Reddy GB (2014b) Effect of chronic hyperglycemia on crystallin levels in rat lens. Biochem Biophys Res Commun 446:602–607
Reddy VS, Jakhotia S, Reddy PY, Reddy GB (2015) Hyperglycemia induced expression, phosphorylation, and translocation of alphaB-crystallin in rat skeletal muscle. IUBMB Life 67:291–299
Reddy VS, Madala SK, Trinath J, Reddy GB (2018) Extracellular small heat shock proteins: exosomal biogenesis and function. Cell Stress Chaperones 23:441–454
Roelofs MF, Boelens WC, Joosten LA, Abdollahi-Roodsaz S, Geurts J, Wunderink LU, Schreurs BW, van den Berg WB, Radstake TR (2006) Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. J Immunol 176:7021–7027
Rothbard JB, Zhao X, Sharpe O, Strohman MJ, Kurnellas M, Mellins ED, Robinson WH, Steinman L (2011) Chaperone activity of alpha B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis. J Immunol 186:4263–4268
Rothbard JB, Kurnellas MP, Brownell S, Adams CM, Su L, Axtell RC, Chen R, Fathman CG, Robinson WH, Steinman L (2012) Therapeutic effects of systemic administration of chaperone alphaB-crystallin associated with binding proinflammatory plasma proteins. J Biol Chem 287:9708–9721
Rothbard JB, Kurnellas MP, Ousman SS, Brownell S, Rothbard JJ, Steinman L (2019) Small heat shock proteins, amyloid fibrils, and nicotine stimulate a common immune suppressive pathway with implications for future therapies. Cold Spring Harb Perspect Med 9
Saez-Torres I, Brieva L, Espejo C, Barrau MA, Montalban X, Martinez-Caceres EM (2002) Specific proliferation towards myelin antigens in patients with multiple sclerosis during a relapse. Autoimmunity 35:45–50
Saini S, Liu T, Yoo J (2016) TNF-alpha stimulates colonic myofibroblast migration via COX-2 and Hsp27. J Surg Res 204:145–152
Salari S, Seibert T, Chen YX, Hu T, Shi C, Zhao X, Cuerrier CM, Raizman JE, O’Brien ER (2013) Extracellular HSP27 acts as a signaling molecule to activate NF-kappaB in macrophages. Cell Stress Chaperones 18:53–63
Sanbe A, Marunouchi T, Abe T, Tezuka Y, Okada M, Aoki S, Tsumura H, Yamauchi J, Tanonaka K, Nishigori H, Tanoue A (2013) Phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse. J Biol Chem 288:8910–8921
Saraswathy S, Nguyen AM, Rao NA (2010) The role of TLR4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 51:3680–3686
Shao W, Zhang SZ, Tang M, Zhang XH, Zhou Z, Yin YQ, Zhou QB, Huang YY, Liu YJ, Wawrousek E, Chen T, Li SB, Xu M, Zhou JN, Hu G, Zhou JW (2013) Suppression of neuroinflammation by astrocytic dopamine D2 receptors via alphaB-crystallin. Nature 494:90–94
Sharma KK, Kumar RS, Kumar GS, Quinn PT (2000) Synthesis and characterization of a peptide identified as a functional element in alphaA-crystallin. J Biol Chem 275:3767–3771
Sharma AK, Bharti S, Ojha S, Bhatia J, Kumar N, Ray R, Kumari S, Arya DS (2011) Up-regulation of PPARgamma, heat shock protein-27 and -72 by naringin attenuates insulin resistance, beta-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes. Br J Nutr 106:1713–1723
Shi C, Ulke-Lemee A, Deng J, Batulan Z, O’Brien ER (2019) Characterization of heat shock protein 27 in extracellular vesicles: a potential anti-inflammatory therapy. FASEB J 33:1617–1630
Shiota M, Bishop JL, Nip KM, Zardan A, Takeuchi A, Cordonnier T, Beraldi E, Bazov J, Fazli L, Chi K, Gleave M, Zoubeidi A (2013) Hsp27 regulates epithelial mesenchymal transition, metastasis, and circulating tumor cells in prostate cancer. Cancer Res 73:3109–3119
Singh BN, Rao KS, Rao Ch M (2010) Ubiquitin-proteasome-mediated degradation and synthesis of MyoD is modulated by alphaB-crystallin, a small heat shock protein, during muscle differentiation. Biochim Biophys Acta 1803:288–299
Sitterding SM, Wiseman WR, Schiller CL, Luan C, Chen F, Moyano JV, Watkin WG, Wiley EL, Cryns VL, Diaz LK (2008) AlphaB-crystallin: a novel marker of invasive basal-like and metaplastic breast carcinomas. Ann Diagn Pathol 12:33–40
Stoevring B, Vang O, Christiansen M (2005) (alpha)B-crystallin in cerebrospinal fluid of patients with multiple sclerosis. Clin Chim Acta; Int J Clin Chem 356:95–101
Stojic A, Bojcevski J, Williams SK, Bas-Orth C, Nessler S, Linington C, Diem R, Fairless R (2019) Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis. Glia 67:512–524
Stope MB, Klinkmann G, Diesing K, Koensgen D, Burchardt M, Mustea A (2017) Heat shock protein HSP27 secretion by ovarian cancer cells is linked to intracellular expression levels, occurs independently of the endoplasmic reticulum pathway and HSP27’s phosphorylation status, and is mediated by exosome liberation. Dis Markers 2017:1575374
Sur R, Lyte PA, Southall MD (2008) Hsp27 regulates pro-inflammatory mediator release in keratinocytes by modulating NF-kappaB signaling. J Invest Dermatol 128:1116–1122
Takashi M, Katsuno S, Sakata T, Ohshima S, Kato K (1998) Different concentrations of two small stress proteins, alphaB crystallin and HSP27 in human urological tumor tissues. Urol Res 26:395–399
Tallot P, Grongnet JF, David JC (2003) Dual perinatal and developmental expression of the small heat shock proteins [FC12]aB-crystallin and Hsp27 in different tissues of the developing piglet. Biol Neonate 83:281–288
Tanaka N, Tanaka R, Tokuhara M, Kunugi S, Lee YF, Hamada D (2008) Amyloid fibril formation and chaperone-like activity of peptides from alphaA-crystallin. Biochemistry 47:2961–2967
Taylor RP, Benjamin IJ (2005) Small heat shock proteins: a new classification scheme in mammals. J Mol Cell Cardiol 38:433–444
Thuringer D, Jego G, Wettstein G, Terrier O, Cronier L, Yousfi N, Hebrard S, Bouchot A, Hazoume A, Joly AL, Gleave M, Rosa-Calatrava M, Solary E, Garrido C (2013) Extracellular HSP27 mediates angiogenesis through toll-like receptor 3. FASEB J 27:4169–4183
Thuringer D, Berthenet K, Cronier L, Solary E, Garrido C (2015) Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells. Oncotarget 6:28800–28815
Tukaj S, Kaminski M (2019) Heat shock proteins in the therapy of autoimmune diseases: too simple to be true? Cell Stress Chaperones 24:475–479
van de Bovenkamp M, Groothuis GMM, Meijer DKF, Slooff MJH, Olinga P (2006) Human liver slices as an in vitro model to study toxicity-induced hepatic stellate cell activation in a multicellular milieu. Chem Biol Interact 162:62–69
van Noort JM, van Sechel AC, Bajramovic JJ, el Ouagmiri M, Polman CH, Lassmann H, Ravid R (1995) The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis. Nature 375:798–801
van Noort JM, Bajramovic JJ, Plomp AC, van Stipdonk MJ (2000) Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis. J Neuroimmunol 105:46–57
van Noort JM, Verbeek R, Meilof JF, Polman CH, Amor S (2006) Autoantibodies against alpha B-crystallin, a candidate autoantigen in multiple sclerosis, are part of a normal human immune repertoire. Mult Scler 12:287–293
van Noort JM, Bsibsi M, Nacken PJ, Gerritsen WH, Amor S, Holtman IR, Boddeke E, van Ark I, Leusink-Muis T, Folkerts G, Hennink WE, Amidi M (2013) Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles. Biomaterials 34:831–840
van Noort JM, Bsibsi M, Nacken PJ, Verbeek R, Venneker EH (2015) Therapeutic intervention in multiple sclerosis with alpha B-Crystallin: a randomized controlled phase IIa trial. PLoS One 10:e0143366
Velotta JB, Kimura N, Chang SH, Chung J, Itoh S, Rothbard J, Yang PC, Steinman L, Robbins RC, Fischbein MP (2011) alphaB-crystallin improves murine cardiac function and attenuates apoptosis in human endothelial cells exposed to ischemia-reperfusion. Ann Thorac Surg 91:1907–1913
Vicart P, Caron A, Guicheney P, Li Z, Prevost MC, Faure A, Chateau D, Chapon F, Tome F, Dupret JM, Paulin D, Fardeau M (1998) A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy. Nat Genet 20:92–95
Vidyasagar A, Reese S, Acun Z, Hullett D, Djamali A (2008) HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis. Am J Physiol Renal Physiol 295:F707–F716
Voll EA, Ogden IM, Pavese JM, Huang X, Xu L, Jovanovic BD, Bergan RC (2014) Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression. Oncotarget 5:2648–2663
Wang H, Xing J, Wang F, Han W, Ren H, Wu T, Chen W (2010) Expression of Hsp27 and Hsp70 in lymphocytes and plasma in healthy workers and coal miners with lung cancer. J Huazhong Univ Sci Technol Med Sci = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao Yixue Yingdewen ban 30:415–420
Wang X, Gu H, Huang W, Peng J, Li Y, Yang L, Qin D, Essandoh K, Wang Y, Peng T, Fan GC (2016) Hsp20-mediated activation of exosome biogenesis in cardiomyocytes improves cardiac function and angiogenesis in diabetic mice. Diabetes 65:3111–3128
Wettstein G, Bellaye PS, Kolb M, Hammann A, Crestani B, Soler P, Marchal-Somme J, Hazoume A, Gauldie J, Gunther A, Micheau O, Gleave M, Camus P, Garrido C, Bonniaud P (2013) Inhibition of HSP27 blocks fibrosis development and EMT features by promoting snail degradation. FASEB J 27:1549–1560
Wu N, Wang YH, Zhao HS, Liu DN, Ying X, Yin ZQ, Wang Y (2009) alpha-crystallin downregulates the expression of TNF-alpha and iNOS by activated rat retinal microglia in vitro and in vivo. Ophthalmic Res 42:21–28
Wu N, Yu J, Chen S, Xu J, Ying X, Ye M, Li Y, Wang Y (2014) Alpha-Crystallin protects RGC survival and inhibits microglial activation after optic nerve crush. Life Sci 94:17–23
Wu J, Liu T, Rios Z, Mei Q, Lin X, Cao S (2017) Heat shock proteins and cancer. Trends Pharmacol Sci 38:226–256
Xu W, Guo Y, Huang Z, Zhao H, Zhou M, Huang Y, Wen D, Song J, Zhu Z, Sun M, Liu CY, Chen Y, Cui L, Wang X, Liu Z, Yang Y, Du P (2019) Small heat shock protein CRYAB inhibits intestinal mucosal inflammatory responses and protects barrier integrity through suppressing IKKbeta activity. Mucosal Immunol
Yang K, Meinhardt A, Zhang B, Grzmil P, Adham IM, Hoyer-Fender S (2012) The small heat shock protein ODF1/HSPB10 is essential for tight linkage of sperm head to tail and male fertility in mice. Mol Cell Biol 32:216–225
Ye S, Zhang C, Zhou J, Cheng J, Lv Z, Zhou L, Xie H, Wu J, Zheng S (2014) Human heat shock protein 27 exacerbates ischemia reperfusion injury in rats by reducing the number of T regulatory cells. Mol Med Rep 9:1998–2002
Yu DW, Ge PP, Liu AL, Yu XY, Liu TT (2019a) HSP20-mediated cardiomyocyte exosomes improve cardiac function in mice with myocardial infarction by activating Akt signaling pathway. Eur Rev Med Pharmacol Sci 23:4873–4881
Yu L, Liang Q, Zhang W, Liao M, Wen M, Zhan B, Bao H, Cheng X (2019b) HSP22 suppresses diabetes-induced endothelial injury by inhibiting mitochondrial reactive oxygen species formation. Redox Biol 21:101095
Yusuf N, Nasti TH, Huang CM, Huber BS, Jaleel T, Lin HY, Xu H, Elmets CA (2009) Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity. J Immunol 182:675–683
Zhang C, Jones JT, Chand HS, Wathelet MG, Evans CM, Dickey B, Xiang J, Mebratu YA, Tesfaigzi Y (2018) Noxa/HSP27 complex delays degradation of ubiquitylated IkBalpha in airway epithelial cells to reduce pulmonary inflammation. Mucosal Immunol 11:741–751
Zhang J, Liu J, Wu J, Li W, Chen Z, Yang L (2019) Progression of the role of CRYAB in signaling pathways and cancers. Onco Targets Ther 12:4129–4139
Zoubeidi A, Gleave M (2012) Small heat shock proteins in cancer therapy and prognosis. Int J Biochem Cell Biol 44:1646–1656
Acknowledgements
Apologies to all those whose work in the field has not been cited due to lack of space. VSR acknowledges the Science and Engineering Research Board-Early Career Research (SERB-ECR) grant (ECR2017/000277/LS), Department of Biotechnology (DBT; BT/PR27607/PFN/20/1338/2018), Government of India for the support. GBR acknowledges the financial assistance from the Department of Science and Technology, Government of India (Grant # EMR/2016/001984) and Department of Health Research, Government of India (Grant # V.25011/287-HRD/2016-HR). TJ acknowledges the OPERA award from BITS-Pilani Hyderabad.
Conflict of Interest
The authors declare that they have no conflict of interest.
Ethical Approval for Studies Involving Humans
This article does not contain any studies with human participants performed by any of the authors.
Ethical Approval for Studies Involving Animals
This article does not contain any studies with animals performed by any of the authors.
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Reddy, V.S., Jamma, T., Reddy, G.B. (2020). Small Heat Shock Proteins in Inflammatory Diseases. In: Asea, A.A.A., Kaur, P. (eds) Heat Shock Proteins in Inflammatory Diseases. Heat Shock Proteins, vol 22. Springer, Cham. https://doi.org/10.1007/7515_2020_9
Download citation
DOI: https://doi.org/10.1007/7515_2020_9
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-85167-5
Online ISBN: 978-3-030-85168-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)