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Protective Role of Heat Shock Proteins During Neurodegeneration in Parkinson’s Disease

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Heat Shock Proteins in Inflammatory Diseases

Part of the book series: Heat Shock Proteins ((HESP,volume 22))

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Abbreviations

Ach:

Acetylcholine

AD:

Alzheimer’s disease

ALP:

Autophagy-lysosomal pathways

ALS:

Amyotrophic lateral sclerosis

AZ:

Active zone

BAG1:

BAG family molecular chaperone regulator 1

CHIP:

Carboxyl terminus of HSC70-interacting protein

CMA:

Chaperone-mediated autophagy

DA:

Dopamine/dopaminergic

DAT:

Dopamine transporter

DLB:

Dementia with Lewy Bodies

EOPD:

Early-onset Parkinson’s disease

ER:

Endoplasmic reticulum

FTD:

Frontotemporal dementia

GPe:

External globus pallidus

GPi:

Internal globus pallidus

HD:

Huntington’s disease

HIP:

HSC70-interacting protein

HOP:

HSP40 and HSP70–HSP90 organizing protein

HSC70:

Heat shock cognate 71 kda protein

HSEs:

HSP Sequence-binding Elements

HSF:

Heat shock factors

HSP:

Heat shock protein

LAMP2A:

Lysosome-associated membrane protein type 2A

LBs:

Lewy bodies

LC3:

Light chain 3/ALP marker

MPTP :

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

MW:

Molecular weight

NAC:

Non-amyloid-β component

NT:

Neurotransmitter

PD:

Parkinson’s disease

PSI :

Peptidyl aldehyde selective inhibitor

PTM:

Post-translational modification

RAC:

Ribosome-associated complex

ROS:

Reactive oxygen species

sHSP:

Small Heat shock protein

SNpc:

Substantia nigra pars compacta

SNpr:

Substantia nigra pars reticulata

STN:

Subthalamic nucleus

SV:

Synaptic vesicle

Ub:

Ubiquitin

UCH-L1 :

Ubiquitin carboxy-terminal hydrolase L1

UPS:

Ubiquitin-proteasome system

VMAT2:

Vesicular monoamine transporter 2

α-Syn:

α-Synuclein

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Acknowledgements

This work was supported by the PhD program of biotechnology at the Institute of Graduate Studies and Research (IGSR), Alexandria University, Alexandria, Egypt.

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Authors and Affiliations

  1. Department of Biotechnology, Institute of Graduate Studies and Research (IGSR), Alexandria University, Alexandria, Egypt

    Amr Ghit

  2. Department of Biology and Biotechnology, University of Pavia, Pavia, Italy

    Amr Ghit

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  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Punit Kaur

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Ghit, A. (2020). Protective Role of Heat Shock Proteins During Neurodegeneration in Parkinson’s Disease. In: Asea, A.A.A., Kaur, P. (eds) Heat Shock Proteins in Inflammatory Diseases. Heat Shock Proteins, vol 22. Springer, Cham. https://doi.org/10.1007/7515_2020_23

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