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Biocatalysis in Flow for Drug Discovery

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Flow Chemistry in Drug Discovery

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 38))

Abstract

The use of enzymes in organic synthesis has seen a significant rise in the past 20 years. This is due to the increased application of directed evolution, allowing enzymes to be improved to the point of being the best catalyst for a specific function. In relation to drug manufacture, this has seen engineered biocatalysts used in several manufacturing processes. But in early-stage drug discovery, there is much less direct application. This has been attributed to slow pace of biocatalysts not matching up to the speed required in drug discovery. In this context, it seems flow chemistry can offer a route into discovery programmes for biocatalysis. This chapter will discuss some recent advances of biocatalysis in continuous flow and consider how this can impact on the use of enzymes in drug discovery programmes.

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Authors and Affiliations

  1. Future Biomanufacturing Research Hub, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK

    Itziar Peñafiel & Sebastian C. Cosgrove

  2. Lennard-Jones Laboratories, School of Chemical and Physical Sciences, Keele University, Staffordshire, UK

    Sebastian C. Cosgrove

Authors
  1. Itziar Peñafiel
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  2. Sebastian C. Cosgrove
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Correspondence to Itziar Peñafiel or Sebastian C. Cosgrove .

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Editors and Affiliations

  1. Discovery Chemistry, Janssen Pharmaceutical Companies of J&J, Janssen-Cilag, S.A., Toledo, Spain

    Jesus Alcazar

  2. Faculty of Chemistry, University of Castilla-La Mancha, Ciudad Real, Ciudad Real, Spain

    Antonio de la Hoz

  3. Faculty of Chemistry, University of Castilla-La Mancha, Ciudad Real, Spain

    Angel Díaz-Ortiz

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Funding: Itziar Peñafiel and Sebastian C. Cosgrove. Both acknowledge The UK Catalysis Hub for funding. Sebastian C. Cosgrove also acknowledges Keele University for funding.

Informed Consent: All procedures in this manuscript were not performed with human participants.

Ethical Approval: All procedures in this manuscript were not performed with human participants, nor any other animals.

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Peñafiel, I., Cosgrove, S.C. (2021). Biocatalysis in Flow for Drug Discovery. In: Alcazar, J., de la Hoz, A., Díaz-Ortiz, A. (eds) Flow Chemistry in Drug Discovery. Topics in Medicinal Chemistry, vol 38. Springer, Cham. https://doi.org/10.1007/7355_2021_116

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