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Carbohydrate-Based Anti-Virulence Compounds Against Chronic Pseudomonas aeruginosa Infections with a Focus on Small Molecules

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Carbohydrates as Drugs

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 12))

Abstract

The Gram-negative bacterium Pseudomonas aeruginosa can establish life-threatening chronic infections through biofilm formation. The two bacterial lectins LecA and LecB play important roles in the formation of these biofilms and the inhibition of the lectins with carbohydrate-based ligands was shown to disrupt biofilms. These effects provide a novel therapeutic option against infections caused by P. aeruginosa. In addition to the urgent need for novel therapeutics against Pseudomonas infections, two major advantages arise from these lectins as targets for therapy: (1) the extracellular localization and site of activity of LecA and LecB circumvent the bacterial cell envelope as a particularly impermeable barrier of Gram-negative pathogens, which must be overcome by drugs against intracellular targets, and (2) the lectins are targets of the so-called anti-virulence therapy and therefore a reduced appearance of resistances towards lectin-directed drugs can be anticipated. In this review, the recent development of carbohydrate-based inhibitors against both lectins is summarized with a main focus on small molecules.

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Acknowledgements

A.T. acknowledges the Helmholtz Association for financial support.

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  1. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus C 2.3, D-66123, Saarbrücken, Germany

    Alexander Titz

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  1. Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany

    Peter H. Seeberger

  2. Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany

    Christoph Rademacher

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Titz, A. (2014). Carbohydrate-Based Anti-Virulence Compounds Against Chronic Pseudomonas aeruginosa Infections with a Focus on Small Molecules. In: Seeberger, P., Rademacher, C. (eds) Carbohydrates as Drugs. Topics in Medicinal Chemistry, vol 12. Springer, Cham. https://doi.org/10.1007/7355_2014_44

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