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Blood–Brain Barrier and Stroke

  • David Fernández-López
  • Zinaida S. VexlerEmail author
Chapter
Part of the Topics in Medicinal Chemistry book series (TMC, volume 10)

Abstract

Stroke disintegrates communications within a highly dynamic and regulated ensemble of cells that constitutes the blood–brain barrier (BBB), endothelial cells, astrocytic end feet that surround blood vessels, the basement membrane (BM)/extracellular matrix (ECM), and pericytes, inducing and propagating injury. We discuss the effects of experimental stroke on individual cell constituents of the BBB and how these changes affect structural and functional integrity of the BBB in relation to acute injury and repair. The age at the time of stroke, from the newborn period to adulthood and older, can markedly affect the particulars of deregulation, processes that we also discuss in this chapter.

Keywords

Extracellular matrix Inflammation Microglia Middle cerebral artery occlusion Neonatal stroke 

Notes

Acknowledgements

The authors have been supported by RO1 NS55915 (Z.S.V), RO1 NS44025 (Z.S.V), R21 NS80015 (Z.S.V), NS35902 (Z.S.V), AHA GIA 0855235F (Z.S.V), Ramon Areces Foundation, Madrid, Spain (D.F.L), and AHA postdoctoral fellowship (D.F.L.).

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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of NeurologyUniversity of California San FranciscoSan FranciscoUSA

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