NMR Spectroscopy in Fragment Based Drug Design

  • Maurizio PellecchiaEmail author
Part of the Topics in Medicinal Chemistry book series (TMC, volume 5)


In this chapter we will briefly reiterate critical aspects of solution nuclear magnetic resonance (NMR) spectroscopy approaches and their applications in drug discovery. These approaches are essentially based on a number of NMR techniques that have been developed to monitor and characterize intermolecular interactions. By way of examples, we will illustrate the unique advantages that these techniques offer when employed in conjunction with fragment-based ligand design, especially when tackling challenging drug targets.


NMR drug discovery fragment based drug discovery SAR by NMR SAR by ILOEs hit to lead 



Several review articles cover in much greater details numerous NMR applications that have been reported in the past years on the use of NMR spectroscopy in the drug discovery process and to monitor target-ligand interactions. The author apologizes if he was unable to mention properly all this work within the limited space of this article.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Burnham Institute for Medical ResearchLa JollaUSA

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