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Alzheimer's Disease pp 81–106Cite as

PPARγ Agonists for the Treatment of Alzheimer's Disease

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Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 2))

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disorder with aging, genetic and environmental factors contributing to the development and progression of the disease. The complexity of this disease presents substantial challenges for the development of new therapeutic agents. AD is typified by pathological depositions of β-amyloid peptides (Aβ) and neurofibrillary tangles within the diseased brain. AD has also been demonstrated to be associated with a significant microglia-mediated inflammatory component, dysregulated lipid homeostasis as well as regional deficits in glucose metabolism within the brain. The peroxisome proliferator-activated receptor-γ (PPARγ) is a prototypical ligand-activated nuclear receptor which coordinates lipid, glucose and energy metabolism and is found at elevated levels in the AD brain. A recently appreciated physiological function of this type of receptor is its ability to modulate inflammatory responses. Thus, PPARγ may act to modulate multiple pathophysiologic mechanisms that contribute to the disease and represents an attractive therapeutic target for the treatment of AD.

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Authors and Affiliations

  1. Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, 10900 Euclid Ave., 44106, Cleveland, OH, USA

    Qingguang Jiang, Shweta Mandrekar & Gary Landreth

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  1. Qingguang Jiang
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  2. Shweta Mandrekar
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  3. Gary Landreth
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Correspondence to Gary Landreth .

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Lit-Fui Lau Michael A. Brodney

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Jiang, Q., Mandrekar, S., Landreth, G. (2007). PPARγ Agonists for the Treatment of Alzheimer's Disease. In: Lau, LF., Brodney, M.A. (eds) Alzheimer's Disease. Topics in Medicinal Chemistry, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7355_2007_014

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