Abstract
Life depends upon multiple metals. It is estimated that approximately one-third of all gene products require a metal for folding and/or catalysis. How does the correct metal locate to the correct protein? Provision of sufficient atoms of each of the metals required by protein metal-binding sites is a challenge for cell biology. This is often especially true for iron, which is poorly soluble under aerobic conditions. Protein metal-binding sites follow universal affinity series. Under such a regime, exclusion of the wrong metals from metalloproteins is arguably an even greater challenge. High-fidelity homeostasis must match the number of some metal cations to the number of bonafide metal-binding sites. Selective protein–protein interactions also limit access of some atoms to the required subsets of proteins. Here we provide an overview of the contributions of metal sensors, metallochaperones, metal transporters and metal-storage proteins to the allocation of metals in cells. In this chapter an emphasis is placed on studies of the cell biology of metals in cyanobacteria.
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Tottey, S., Harvie, D.R., Robinson, N.J. (2007). Understanding How Cells Allocate Metals. In: Nies, D.H., Silver, S. (eds) Molecular Microbiology of Heavy Metals. Microbiology Monographs, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7171_2006_072
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