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l-Serine and Glycine

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Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic Engineering

Part of the book series: Microbiology Monographs ((MICROMONO,volume 5))

Abstract

The biosynthesis of glycine and l-serine is closely connected, and both amino acids are produced in industry. However, whereas glycine is made chemically, l-serine production relies largely on microbial processes. These include conversions of added glycine by C-1 utilizing microorganisms. But such precursor conversions usually suffer from low yields, as did previous attempts to produce l-serine from glucose. As more recent molecular and physiological studies have shown, microorganisms like Corynebacterium glutamicum have a high l-serine degradation capacity corresponding to an apparent key position of this amino acid in metabolism. Considering this key position, deletion of a serine dehydratase gene and prevention of folate synthesis to reduce serine hydroxymethyltransferase activity together with increased biosynthesis resulted in l-serine producers of C. glutamicum with excellent production characteristics and maximal specific productivities of 1.45 mmol g−1 h−1 accumulating more than 50 g l−1 l-serine.

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  1. Institute for Biotechnology 1, Research Centre Juelich, 52425, Juelich, Germany

    Lothar Eggeling

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  1. Lothar Eggeling
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Correspondence to Lothar Eggeling .

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Volker F. Wendisch

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Eggeling, L. (2007). l-Serine and Glycine. In: Wendisch, V.F. (eds) Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic Engineering. Microbiology Monographs, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7171_2006_068

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