Clinical Wound Healing Using Signal Inhibitors
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The cases presented in this chapter demonstrate the amazing improvement in wound-healing trajectory that is best explained by the suppression of biofilms. The individual patient with a chronic wound is not much better served today than a decade ago despite all of the advances achieved. The rate of major limb amputation and mortality is not decreasing, and the quality of life of these patients is not improving. Chronic wounds have a much higher prevalence rate of biofilms than acute ones, suggesting that presence of a biofilm is an important factor in the lack of healing of chronic wounds. As shown in this chapter, the implementation of the quorum-sensing inhibitor RNAIII-inhibiting peptide in managing complex wounds, along with other anti-biofilm strategies like lactoferrin, has dramatically changed the positive outcomes for many of the most desperate wounds.
KeywordsExtracellular Polymeric Substance Chronic Wound Planktonic Bacterium Extracellular Polymeric Substance Production Individual Bacterium
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