Quorum-Sensing Inhibitory Compounds

Part of the Springer Series on Biofilms book series (BIOFILMS, volume 2)


Biofilm formation plays an important role in antimicrobial resistance, posing a global threat to the economy and public health. Hence, discovery of novel antagonists is critical. In this chapter, we introduce a class of compounds, brominated furanones, which have a broad spectrum of activities against bacterial multicellular behaviors, such as biofilm formation and quorum sensing. The application of these compounds and the mechanisms of inhibition are reviewed. This chapter also reviews inhibitors of quorum sensing in Gram-positive bacteria, especially those of staphylococci. The use of these inhibitors to prevent and treat biofilm diseases in humans and animals is shown in subsequent chapters.


Garlic Extract Mild Steel Surface LuxR Homolog LuxI Homolog LuxR Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  1. 1.Syracuse UniversityDepartment of Biomedical and Chemical EngineeringSyracuseUSA
  2. 2.BioCentrum-DTUTechnical University of DenmarkKgs LyngbyDenmark
  3. 3.Innovation, Cultures & Enzymes DivisionHørsholmDenmark
  4. 4.Tufts University, Cummings School of Veterinary MedicineDepartment of Biomedical Sciences, Division of Infectious DiseasesNorth GraftonUSA

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