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Detection In Vitro of Quorum-Sensing Molecules and Their Inhibitors

Chapter
Part of the Springer Series on Biofilms book series (BIOFILMS, volume 2)

Abstract

Bacterial population density signaling (quorum signaling) is now recognized as a widespread phenomenon in microorganisms. In some cases, quorum signaling is an essential regulatory component of virulence and other attributes, including biofilm formation. Several organisms compete with bacteria by virtue of disrupting quorum signal production or the signal receptor, or by degrading the signals themselves. While some have been described in the literature, many others await discovery. Here, we explore bioassay-based strategies that could be used to identify novel quorum-signal inhibitors.

Keywords

Quorum Sense Homoserine Lactone Triacylglycerol Lipase luxR Homolog Biosensor Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  1. 1.Department of BiologyTexas State University-San MarcosSan MarcosUSA
  2. 2.Department of Microbiology and ImmunologyUniversity of Texas Health Science Center at San AntonioSan AntonioUSA
  3. 3.Department of Family and Consumer SciencesMolecular and Cellular Nutrition Program, Texas State University-San MarcosSan MarcosUSA
  4. 4.BioCentrum-DTUTechnical University of DenmarkKgs LyngbyDenmark
  5. 5.Innovation, Cultures & Enzymes DivisionHørsholmDenmark
  6. 6.Cummings School of Veterinary Medicine, Department of Biomedical SciencesTufts UniversityNorth GraftonUSA

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