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Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective

  • Andrew R. BogdanEmail author
  • Michael G. Organ
Chapter
Part of the Topics in Heterocyclic Chemistry book series (TOPICS, volume 56)

Abstract

The applications of flow chemistry in a drug discovery environment are discussed within. The development of integrated synthesis–bioassay platforms is discussed in the context of enabling medicinal chemistry programs, as is the use of flow chemistry to facilitate intermediate scale-up in a lead optimization setting. Emerging chemical technologies are also discussed, highlighting the use of high temperatures, hazardous gases, and photochemistry in flow to support medicinal chemistry efforts.

Keywords

Drug discovery Emerging technologies Flow chemistry Integrated systems Lead optimization Medicinal chemistry 

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Discovery Chemistry and Technology, AbbVie, Inc.North ChicagoUSA
  2. 2.Department of Chemistry and Biomolecular SciencesUniversity of OttawaOttawaCanada

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