Flow-Assisted Synthesis of Heterocycles via Multicomponent Reactions

  • Seger Van Mileghem
  • Cedrick Veryser
  • Wim M. De Borggraeve
Part of the Topics in Heterocyclic Chemistry book series (TOPICS, volume 56)


Multicomponent reactions (MCRs) are of great significance in organic synthesis. They often decrease the number of synthesis steps since three or more reactants are incorporated in the product in a single step. This increases the number of combinatorial options and allows more efficient processes in less time. The pharmaceutical industry is therefore very fond of MCRs for the construction of libraries. As a consequence, the field is being investigated intensely for the enhancement of chemical processes and the discovery of new types of MCRs.

The combination of the benefits of flow technology and MCRs for heterocycle synthesis is an interesting and specialized field. This chapter serves as an overview of the literature covering this topic starting from 2010, up to when the literature on this matter is reviewed in a book chapter in this book series by Cukalovic et al. (Top Heterocycl Chem 23:161–198, 2010).


Continuous flow Heterocycles Multicomponent reactions Synthesis 





Acetic acid




Back-pressure regulator




















Diethyl ether




Ethyl acetate










Multicomponent reaction








Polyethylene glycol 200


Polyethylene glycol 300


Perfluoroalkoxy alkane


Pound-force per square inch


Polytetrafluoroethylene (Telfon®)


tert-Butyl nitrite


Trimethylsilyl azide


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Seger Van Mileghem
    • 1
  • Cedrick Veryser
    • 1
  • Wim M. De Borggraeve
    • 1
  1. 1.Molecular Design and Synthesis, Department of ChemistryKU LeuvenLeuvenBelgium

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