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Flow Chemistry for the Synthesis of Heterocycles pp 237–317Cite as

Functionalization of Heteroarenes Under Continuous Flow

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Part of the Topics in Heterocyclic Chemistry book series (TOPICS,volume 56)

Abstract

Aromatic heterocycles are omnipresent motifs in pharmaceutical and agrochemical structures. Functionalization of these ring systems is an important part of many synthetic procedures. In this chapter, an overview is given of how microflow technology has been employed as a powerful tool for the diversification of heteroarenes. An emphasis is put on fine chemical synthesis, although reactor design and problem solving will be discussed when relevant, as it comprises an important part of the research field. Pragmatic translations to microflow are reviewed for existing functionalization protocols, and a few elusive reactions are highlighted that cannot be performed satisfyingly in batch mode.

Keywords

  • Continuous flow
  • Cross-coupling
  • Functionalization
  • Heterocycles

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  • DOI: 10.1007/7081_2018_22
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Authors and Affiliations

  1. Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Leuven, Belgium

    Joachim Demaerel, Vidmantas Bieliūnas & Wim M. De Borggraeve

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  1. Joachim Demaerel
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  2. Vidmantas Bieliūnas
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  3. Wim M. De Borggraeve
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Correspondence to Wim M. De Borggraeve .

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Editors and Affiliations

  1. Department of Chemistry, University of Leuven (KU Leuven), Leuven, Belgium

    Dr. Upendra K. Sharma

  2. Department of Chemistry, University of Leuven (KU Leuven), Leuven, Belgium

    Prof. Dr. Erik V. Van der Eycken

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Demaerel, J., Bieliūnas, V., De Borggraeve, W.M. (2018). Functionalization of Heteroarenes Under Continuous Flow. In: Sharma, U., Van der Eycken, E. (eds) Flow Chemistry for the Synthesis of Heterocycles. Topics in Heterocyclic Chemistry, vol 56. Springer, Cham. https://doi.org/10.1007/7081_2018_22

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