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Flow Chemistry for the Synthesis of Heterocycles pp 1–102Cite as

Multistep Continuous-Flow Processes for the Preparation of Heterocyclic Active Pharmaceutical Ingredients

Part of the Topics in Heterocyclic Chemistry book series (TOPICS,volume 56)

Abstract

Flow chemistry has many fascinating facets, among which the most challenging is arguably the implementation of complex multistep processes within one uninterrupted fluidic network. This document provides a thorough overview of some of the most representative examples of multistep continuous-flow strategies in the specific context of preparing heterocyclic active pharmaceuticals. Selected examples emphasizing the implementation of multistep sequences, including various combinations of chemical transformations, purifications, or in-line analysis, are discussed.

Keywords

  • Flow chemistry
  • Heterocyclic APIs
  • Multistep continuous processes

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Authors and Affiliations

  1. Center for Integrated Technology and Organic Synthesis, Department of Chemistry, University of Liège, Liège, Belgium

    Romaric Gérardy & Jean-Christophe M. Monbaliu

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  1. Romaric Gérardy
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  2. Jean-Christophe M. Monbaliu
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Correspondence to Jean-Christophe M. Monbaliu .

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Editors and Affiliations

  1. Department of Chemistry, University of Leuven (KU Leuven), Leuven, Belgium

    Dr. Upendra K. Sharma

  2. Department of Chemistry, University of Leuven (KU Leuven), Leuven, Belgium

    Prof. Dr. Erik V. Van der Eycken

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Gérardy, R., Monbaliu, JC.M. (2018). Multistep Continuous-Flow Processes for the Preparation of Heterocyclic Active Pharmaceutical Ingredients. In: Sharma, U., Van der Eycken, E. (eds) Flow Chemistry for the Synthesis of Heterocycles. Topics in Heterocyclic Chemistry, vol 56. Springer, Cham. https://doi.org/10.1007/7081_2018_21

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