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Mechanistic Investigations of Copper(I)-Catalysed Alkyne–Azide Cycloaddition Reactions

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Click Triazoles

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 28))

Abstract

The chapter concentrates on mechanistic aspects of thermal and metal catalysed reactions of organic azides and alkynes, particularly terminal alkynes, that result in the formation of 1,2,3-triazoles.

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Acknowledgement

We thank Dr Lei Zhu (University of Florida, Tallahassee) for his valuable comments on an earlier version of this chapter.

Note added in proof An interesting short review on the synthesis of 1,2,3-triazoles involving both thermal (Huisgen) and copper(I) catalysed intramolecular alkyne-azide cycloaddition reactions has appeared [178].

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  1. Department of Chemistry, Loughborough University, Loughborough, Leicestershire, LE11 3 TU, UK

    Benjamin R. Buckley & Harry Heaney

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  1. Benjamin R. Buckley
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Correspondence to Harry Heaney .

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  1. , Faculty of Chemistry and Chemical Techno, University of Ljubljana, Askerceva 5, Ljubljana, 1000, Slovenia

    Janez Košmrlj

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Buckley, B.R., Heaney, H. (2012). Mechanistic Investigations of Copper(I)-Catalysed Alkyne–Azide Cycloaddition Reactions. In: Košmrlj, J. (eds) Click Triazoles. Topics in Heterocyclic Chemistry, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2011_71

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