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Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles

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Click Triazoles

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 28))

Abstract

Although the synthesis of 1,4- or 1,5-disubstituted 1,2,3-triazoles has been popularized by the recent developments of metal-catalyzed 3+2 cycloaddition of organic azides and terminal alkynes, the preparation of 1,4,5-trisubstituted triazoles is less popular. The focus of this chapter is the synthesis of these heterocycles, using condensation reactions and rearrangements, selective preparation of trisubstituted triazoles from disubstituted precursors, and formal [3+2] cycloaddition reactions involving internal alkynes.

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  1. UMR 8638, Université Paris Descartes, CNRS, Faculté de Pharmacie, 4 avenue de l’Observatoire, 75006, Paris, France

    S. Mignani, T. Lecourt & L. Micouin

  2. State Key Laboratory of Fine Chemicals, School of pharmaceutical science and technology, Dalian University of Technology, Dalian, 116024, People’s Republic of China

    Y. Zhou

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  1. S. Mignani
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  4. L. Micouin
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  1. , Faculty of Chemistry and Chemical Techno, University of Ljubljana, Askerceva 5, Ljubljana, 1000, Slovenia

    Janez Košmrlj

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Mignani, S., Zhou, Y., Lecourt, T., Micouin, L. (2012). Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles. In: Košmrlj, J. (eds) Click Triazoles. Topics in Heterocyclic Chemistry, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2011_68

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