Synthesis of Heterocycles Through Classical Ugi and Passerini Reactions Followed by Secondary Transformations Involving One or Two Additional Functional Groups

  • Luca BanfiEmail author
  • Andrea Basso
  • Renata Riva
Part of the Topics in Heterocyclic Chemistry book series (TOPICS, volume 23)


The combination of classical isocyanide-based multicomponent reactions (Ugi and Passerini) with a variety of post-condensation transformations, which take advantage of suitably positioned additional functional groups, allows the straightforward synthesis, often in 1–2 synthetic steps, of many diverse nitrogen-containing heterocycles. This review will cover all the applications of this strategy reported to date (September 2009).


Combinatorial chemistry Diversity-oriented synthesis Isocyanides Multicomponent reactions Passerini reaction Ugi reaction 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department of Chemistry and Industrial ChemistryGenovaItaly

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