Microreactor Technology as an Efficient Tool for Multicomponent Reactions

  • Ana Cukalovic
  • Jean-Christophe M. R. Monbaliu
  • Christian V. Stevens
Part of the Topics in Heterocyclic Chemistry book series (TOPICS, volume 23)


Multicomponent reactions are an important tool in organic synthesis as they often allow the circumvention of multistep procedures by combining three or more molecules into one structure in a single step. An additional asset of the approach is the significant increase of the combinatorial possibilities, since a modification of the final product is easily accomplished by implementing minor changes in the reaction setup; this obviously allows considerable savings in time and resources. These advantages are of particular interest in pharmaceutical research for the construction of libraries. In order to increase the sustainability of chemical processes, the field is intensively explored, and novel reactions are frequently reported. Microreactor technology also offers a contemporary way of conducting chemical reactions in a more sustainable fashion due to the miniaturization and increased safety, and also in a technically improved manner due to intensified process efficiency. This relatively new technology is implemented in novel and improved applications and is getting more and more used in chemical research. The combination of the benefits from the two approaches clearly presents an attractive reaction design, and this chapter presents an overview of the reported examples in which the microreactor technology and the multicomponent approach are combined, usually with dramatically improved results compared to those previously reported.


Continuous flow Heterocycles Microreactor Multicomponent reactions Sustainable processes 



Amberlyst 15


Amberlyst 21








Convection-flow coil










Diphenylphosphoryl azide


Enantiomeric excess


Gas chromatography


High pressure liquid chromatography/high performance liquid chromatography


Internal diameter


Microwave-assisted continuous flow organic synthesis










Polyether ether ketone






Polymer-supported 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine


Polymer-supported tetra-N-alkylammonium perruthenate


Polymer-supported (ditrifluoroacetoxyiodo)benzene






Trimethylsilyl cyanide


Time-of-flight mass spectrometry




Miniaturised synthesis and total analysis system


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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Ana Cukalovic
    • 1
  • Jean-Christophe M. R. Monbaliu
    • 1
  • Christian V. Stevens
    • 1
  1. 1.Research Group SynBioC, Organic Chemistry Department, Faculty of Bioscience EngineeringGhent UniversityGhentBelgium

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