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Cycloaddition Reactions of Azides Including Bioconjugation

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Synthesis of Heterocycles via Cycloadditions I

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 12))

Abstract

Organic azides R-N3, albeit being energy-rich and very reactive, are useful intermediates in organic synthesis. The cycloaddition reaction of azides with double and triple bonds to yield heterocyclic structures – albeit being discovered many centuries ago – has been evolved into a powerful tool in organic synthesis, material sciences and life sciences, and are thus covered in this review. In particular, the recent development of catalytic and therefore mild reaction conditions has led to an enormous increase of systematic investigation and novel applications.

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Authors and Affiliations

  1. University of Karlsruhe (TH), Institute of Organic Chemistry, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany

    S. Bräse, A. Friedrich, M. Gartner & T. Schröder

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  1. S. Bräse
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  2. A. Friedrich
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  4. T. Schröder
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Correspondence to S. Bräse .

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Alfred Hassner

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Bräse, S., Friedrich, A., Gartner, M., Schröder, T. (2008). Cycloaddition Reactions of Azides Including Bioconjugation. In: Hassner, A. (eds) Synthesis of Heterocycles via Cycloadditions I. Topics in Heterocyclic Chemistry, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2007_104

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