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Bioactive Heterocycles III pp 1–31Cite as

Chemistry, Biosynthesis and Biological Activity of Artemisinin and Related Natural Peroxides

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Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 9))

Abstract

Artemisinin is a heterocyclic natural product and belongs to the natural product class of sesquiterpenoids with an unusual 1,2,4 trioxane substructure. Artemisinin is one of the most potent antimalarial drugs available and it serves as a lead compound in the drug development process to identify new chemical derivatives with antimalarial optimized activity and improved bioavailability. In this review we report about the latest status of research on chemical and physical properties of the drug and its derivatives. We describe new strategies to produce artemisinin on a biotechnological level in heterologous hosts and in plant cell cultures. We also summarize recent reports on its pharmacokinetic profile and attempts to develop drug delivery systems to overcome bioavailability problems and to target the drug to Plasmodium infected erythrocytes as main target cells.

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Authors and Affiliations

  1. Pharmaceutical Biology, GUIDE, University of Groningen, Antonius Deusinglaan 1, 9713, AV Groningen, The Netherlands

    Anna-Margareta Rydén & Oliver Kayser

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  1. Anna-Margareta Rydén
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  2. Oliver Kayser
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Correspondence to Oliver Kayser .

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Mahmud Tareq Hassan Khan

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Rydén, AM., Kayser, O. (2007). Chemistry, Biosynthesis and Biological Activity of Artemisinin and Related Natural Peroxides. In: Khan, M.T.H. (eds) Bioactive Heterocycles III. Topics in Heterocyclic Chemistry, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2007_085

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