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Chemistry of the Welwitindolinones

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Bioactive Heterocycles V

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 11))

Abstract

Marine cyanobacteria are a prolific source of bioactive natural products. The welwitindolinones are a group of structurally unique metabolites isolated from cyanobacteria, containing 3,4-bridged or spiro cyclobutaneoxindole moieties. Due to their challenging structures and their broad spectrum of biological activities, these compounds have attracted the attention of synthetic chemists for some time, although so far their complexity has prevented the completion of total syntheses for most of these natural products. This chapter is devoted to a discussion of the current knowledge about the occurrence, biological properties, biosynthesis and synthetic approaches to the welwitindolinones.

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Authors and Affiliations

  1. Universidad Complutense, Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Plaza de Ramón y Cajal, s.n., 28040, Madrid, Spain

    J. Carlos Menéndez

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  1. J. Carlos Menéndez
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Correspondence to J. Carlos Menéndez .

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Mahmud Tareq Hassan Khan

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© 2007 Springer-Verlag Berlin Heidelberg

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Menéndez, J.C. (2007). Chemistry of the Welwitindolinones . In: Khan, M.T.H. (eds) Bioactive Heterocycles V. Topics in Heterocyclic Chemistry, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2007_063

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