Recombination and Meiosis

Volume 2 of the series Genome Dynamics and Stability pp 81-123


Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis

  • Scott KeeneyAffiliated withMolecular Biology Program, Memorial Sloan-Kettering Cancer Center Email author 

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Meiotic recombination is carried out through a specialized pathway for the formation and repair of DNA double-strand breaks made by the Spo11 protein, a relative of archaeal topoisomerase VI. This review summarizes recent studies that provide insight to the mechanism of DNA cleavage by Spo11, functional interactions of Spo11 with other proteins required for break formation, mechanisms that control the timing of recombination initiation, and evolutionary conservation and divergence of these processes.