Abstract
Olfactory stimuli are processed in the human brain in a complex integrative system with other senses, and intimately wired to cortical areas related to the formation of memories, emotions, survival instincts, and language. These findings support the notion that the sense of smell imprints emotional value to objects and events, triggers memories and feelings which affect our moods and judgement, with repercussions on our behaviour and interpersonal relationships. This might explain our fascination with fragrances and pleasant scented materials, a trait that we seem to share with our ancestors and whose social and cultural significance changed over the centuries. Currently, it represents a multi-billion-dollar industry with application in numerous consumer products. With such production rates worldwide, fragrances naturally become a concern for their potential hazardous effects on humans and the environment. First only from natural origin and now predominantly synthetic materials, this wide array of chemicals has several uses according to their physicochemical properties but can impact all environmental compartments and life forms. This chapter gives a comprehensive overview about the types, classification, properties, production rates and main uses of fragrance compounds, as well as the main emission sources to the environment, potential toxicity, and regulatory actions currently in place to prevent hazardous incidences.
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References
Sarafoleanu C, Mella C, Georgescu M, Perederco C (2009) The importance of the olfactory sense in the human behavior and evolution. J Med Life 2(2):196–198
Huber B, Larsen T, Spengler RN, Bolvin N (2022) How to use modern science to reconstruct ancient scents. Nat Hum Behav 6:611–614
Rowe DJ (2004) Introduction. In: Rowe DJ (ed) Chemistry and technology of flavors and fragrances. Blackwell Publishing, Bodmin, pp 1–11
Pybus DH (2006) The history of aroma chemistry and perfume. In: Pybus D, Sell C (eds) The chemistry of fragrances: from perfumer to consumer2nd edn. Royal Society of Chemistry, Cambridge, pp 3–23
Burger P, Plainfossé H, Brochet X, Chemat F, Fernandez X (2019) Extraction of natural fragrance ingredients: history overview and future trends. Chem Biodivers 16:e1900424
Belgiorno MR (2016) The perfume of Cyprus: from Pyrgos to François Coty the route of a millenary charm. Ermes edizioni scientifiche, Ariccia
Levey M (1954) Perfumery in ancient Babylonia. J Chem Educ 31(7):373–375
Brun JP (2000) The production of perfumes in antiquity: the cases of Delos and Paestum. A J Archaeol 104(2):277–308
King AH (2017) Scent from the garden of paradise: musk and the medieval Islamic world. Brill, Leiden
David ORP (2017) Artificial Nitromusks, stories of chemists and businessmen. Eur J Org Chem 2017(1):4–13
Nicolaï P (2008) A smelling trip into the past: the influence of synthetic materials on the history of perfumery. Chem Biodivers 5(6):1134–1146
David ORP (2020) A chemical history of polycyclic Musks. Chem A Eur J 26(34):7537–7555
IFRA (2022) The International Fragrance Association website. https://ifrafragrance.org/home. Accessed 20 July 2022
Sharma A, Kumar R, Aier I, Semwal R, Tyagi P, Varadwaj P (2019) Sense of smell: structural, functional, mechanistic advancements and challenges in human olfactory research. Curr Neuropharmacol 17(9):891–911
Sell C (2006) Chemoreception. In: Pybus D, Sell C (eds) The chemistry of fragrances: from perfumer to consumer2nd edn. Royal Society of Chemistry, Cambridge, pp 229–253
Spence C (2022) The scent of attraction and the smell of success: crossmodal influences on person perception. Cogn Res Princ Implic 6:46
Mintel Group (2014) Fragrance in cosmetics – the smell of success. Presentation at In-Cosmetics, Hamburg. http://www.in-cosmetics.com. Accessed 9 May 2022
Surburg H, Panten J (2006) Common fragrance and flavor materials: preparation, properties and uses.5th edn. WILEY-VCH Verlag GmbH & Co., KGaA, Weinheim
Herman S (2017) Chapter 18 – fragrance. In: Sakamoto K, Lochhead H, Maibach H, Yamashita Y (eds) Cosmetic science and technology: theoretical principles and applications1st edn. Elsevier, pp 267–283
Ohloff G, Winter B, Fehr C (1994) Chapter 9. Chemical classification and structure – odour relationships. In: Müller PM, Lamparsky D (eds) Perfumes: art, science and technology. Springer, Dordrecht, pp 287–330
Bickers DR, Calow P, Greim HA, Hanifin JM, Rogers AE, Saurat JH, Sipes IG, Smith RL, Tagami H (2003) The safety assessment of fragrance materials. Regul Toxicol Pharmacol 37(2):218–273
Date MS, O’Brien D, Botelho DJ, Schultz TW, Liebler DC, Penning TM, Salvito DT (2020) Clustering a chemical inventory for safety assessment of fragrance ingredients: identifying read-across Analogs to address data gaps. Chem Res Toxicol 33(7):1709–1718
The Fragrance Conservatory (2022) The Fragrance Conservatory website, Fragrance Creators Association. https://fragranceconservatory.com/. Accessed 6 July 2022
Sommer C (2004) The role of musk and musk compounds in the fragrance industry. In: Rimkus GG (ed) Series anthropogenic compounds. The handbook of environmental chemistry, vol 3X. Springer, Berlin, pp 1–16
Sell CS, Jenner K (2006) The search for new fragrance ingredients. In: Pybus D, Sell C (eds) The chemistry of fragrances: from perfumer to consumer2nd edn. Royal Society of Chemistry, Cambridge, pp 254–293
Verzele M, Maes G, Vuye A, Godefroot M, van Alboom M, Vervisch J, Sandra P (1981) Chromatographic investigation of Jasmin absolutes. J Chromatogr A 205(2):367–386
Daniau V (2021) Follow the scent – the science behind the fragrance in products. In: Barton S, Eastham A, Isom A, McLaverty D, Soong YL (eds) Discovering cosmetic science1st edn. The Royal Society of Chemistry, London, pp 424–487
IFRA (2020) Fragrance Ingredient Glossary, The International Fragrance Association, April 2020 edition. Available at https://ifrafragrance.org/priorities/ingredients/glossary. Accessed 20 July 2022
Edwards M (2022) Fragrances of the World. https://www.fragrancesoftheworld.com. Accessed 30 Aug 2022
Thiboud M (1994) Chapter 8. Empirical classification of odours. In: Müller PM, Lamparsky D (eds) Perfumes: art, science and technology. Springer, Dordrecht, pp 253–286
Rowe DJ (2004) Aroma chemicals I: C, H, O compounds. In: Rowe DJ (ed) Chemistry and technology of flavors and fragrances. Blackwell Publishing, Bodmin, pp 56–84
Lapczynski A, Bhatia SP, Letizia CS, Api AM (2008) Fragrance material review on dl-citronellol. Food Chem Toxicol 46:S103–S109
Api AM, Belsito D, Bhatia SP, Botelho D, Browne D, Bruze M, Burton A, Buschmann J, Calow P, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Joshi K, Kromidas L, La Cava S, Lalko JF, Lapczynski A, Liebler DC, Miyachi Y, O'Brien D, Parakhia R, Patel A, Penning TM, Politano VT, Ritacco G, Romine J, Salvito D, Schultz TW, Shen J, Sipes IG, Thakkar Y, Tokura Y, Tsang S, Wahler J, Wall B, Wilcox DK (2017) RIFM fragrance ingredient safety assessment, terpineol, CAS registry number 8000-41-7. Food Chem Toxicol 110:S392–S402
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) Update to RIFM fragrance ingredient safety assessment, linalool, CAS registry number 78-70-6. Food Chem Toxicol 159:112687
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) Update to RIFM fragrance ingredient safety assessment, borneol, CAS registry number 507-70-0. Food Chem Toxicol 163:113025
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) RIFM fragrance ingredient safety assessment, cedrol, CAS registry number 77-53-2. Food Chem Toxicol 163:112998
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Cancellieri MA, Chon H, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) RIFM fragrance ingredient safety assessment, geraniol, CAS registry number 106-24-1. Food Chem Toxicol 167:113341
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton Jr GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O’Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S (2020) RIFM fragrance ingredient safety assessment, citral, CAS registry number 5392-40-5. Food Chem Toxicol 141:111339
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton Jr GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O’Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S (2021) RIFM fragrance ingredient safety assessment, citronellal, CAS registry number 106-23-0. Food Chem Toxicol 149:111991
Dorsky J (1994) Chapter 14. The chemistry of synthetic raw materials production. In: Müller PM, Lamparsky D (eds) Perfumes: art, science and technology. Springer, Dordrecht, pp 399–420
Fráter G, Bajgrowicz JA, Kraft P (1998) Fragrance chemistry. Tetrahedron 54:7633–7703
Serra S (2015) Chapter 7 – recent developments in the synthesis of the flavors and fragrances of terpenoid origin. In: Rahman A (ed) Studies in natural products chemistry, vol 46. Elsevier, pp 201–226
Braga A, Guerreiro C, Belo I (2018) Generation of flavors and fragrances through biotransformation and de novo synthesis. Food Bioproc Tech 11:2217–2228
Gupta S, Gupta C, Garg AP, Prakash D (2015) A biotechnological approach to microbial based perfumes and flavours. J Microbiol Exp 2(1):11–18
Givaudan (2022) Shaping tomorrow’s signature fragrances with science. https://www.givaudan.com/fragrance-beauty/ingredients/fragrance-molecules. Accessed 22 Oct 2022
Ahuja K, Baya S (2021) Fragrance ingredients market – summary. Global Market Insights (GMI). https://www.gminsights.com/industry-analysis/fragrance-ingredients-market. Accessed 26 Oct 2022
Expert Market Research (EMR) (2022) North America flavours and fragrances market outlook. https://www.expertmarketresearch.com/reports/north-america-flavours-and-fragrances-market. Accessed 26 Oct 2022
Research and Markets (2022) A global overview of the flavours and fragrances market – executive summary. https://www.researchandmarkets.com/reports/5658621. Accessed 26 Oct 2022
Stepanyuk A, Kirschning A (2019) Synthetic terpenoids in the world of fragrances: Iso E Super® is the showcase. Beilstein J Org Chem 15:2590–2602
RIFM (2022) Research Institute for Fragrance Materials website. https://rifm.org/about-rifm/. Accessed 20 July 2022
European Communities (2008) European Union risk assessment report – 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-γ-2-benzopyran – final approved version. The Netherlands. https://echa.europa.eu/documents/10162/947def3b-bbbf-473b-bc19-3bda7a8da910. Accessed 20 July 2022
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S (2020) RIFM fragrance ingredient safety assessment, 2-ethoxy-4-methylphenol, CAS registry number 2563-07-7. Food Chem Toxicol 144:111657
Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Theophilus EH, Tiethof AK, Tokura Y, Tsang S, Wahler J (2017) RIFM fragrance ingredient safety assessment, 3,7-dimethyl-2,6-nonadienenitrile, CAS registry number 61792-11-8. Food Chem Toxicol 110:S552–S560
Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Buschmann J, Calow P, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Tsang S, Wahler J (2017) RIFM fragrance ingredient safety assessment, 5-Acetyl-3-isopropyl-1,1,2,6-tetramethylindane, CAS registry number 68140-48-7. Food Chem Toxicol 110:S198–S209
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2021) RIFM fragrance ingredient safety assessment, 6,7-dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone. CAS registry number 33704-61-9. Food Chem Toxicol 149:11929
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Calow P, Dagli ML, Dekant W, Fryer AD, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Romine J, Salvito D, Schultz TW, Shen J, Sipes IG, Wahler J (2017) RIFM fragrance ingredient safety assessment, 6-acetyl-1,1,2,4,4,7-hexamethyltetraline, CAS registry number 21145-77-7. Food Chem Toxicol 110:S95–S103
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S (2019) RIFM fragrance ingredient safety assessment, benzaldehyde, CAS registry number 100-52-7. Food Chem Toxicol 134:110878
Api AM, Belmonte F, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S (2020) RIFM fragrance ingredient safety assessment, benzyl benzoate, CAS registry number 120-51-4. Food Chem Toxicol 144:111500
Lapczynski A, McGinty D, Jones L, Bhatia S, Letizia CS, Api AM (2007) Fragrance material review on benzyl salicylate. Food Chem Toxicol 45:S362–S380
Api AM, Belmonte F, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S (2019) RIFM fragrance ingredient safety assessment, cinnamaldehyde, CAS registry number 104-55-2. Food Chem Toxicol 134:110710
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) RIFM fragrance ingredient safety assessment, cis-jasmone, CAS registry number 488-10-8. Food Chem Toxicol 159:112685
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) RIFM fragrance ingredient safety assessment, citronellyl acetate, CAS registry number 150-84-5. Food Chem Toxicol 159:112710
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S (2020) RIFM fragrance ingredient safety assessment, decanoic acid, CAS registry number 334-48-5. Food Chem Toxicol 144:111465
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Cancellieri MA, Chon H, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) RIFM fragrance ingredient safety assessment, ethyl acetate, CAS registry number 141-78-6. Food Chem Toxicol 167:113363
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Cancellieri MA, Chon H, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) Update to RIFM fragrance ingredient safety assessment, ethylene brassylate, CAS registry number 105-95-3. Food Chem Toxicol 169:113459
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) Update to RIFM fragrance ingredient safety assessment, eugenol, CAS registry number 97-53-0. Food Chem Toxicol 163:113027
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S (2020) RIFM fragrance ingredient safety assessment, hexanoic acid, CAS registry number 142-62-1. Food Chem Toxicol 138:111263
Lapczynski A, Jones L, McGinty D, Bhatia S, Letizia CS, Api AM (2007) Fragrance material review on hexyl salicylate. Food Chem Toxicol 45:S410–S417
Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Buschmann J, Calow P, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler DC, O’Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Tsang S, Wahler J (2017) RIFM fragrance ingredient safety assessment, isoamyl acetate, CAS registry number 123-92-2. Food Chem Toxicol 110:S123–S132
Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Buschmann J, Calow P, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Tsang S, Wahler J (2017) RIFM fragrance ingredient safety assessment, isoamyl octanoate, CAS registry number 2035-99-6. Food Chem Toxicol 110:S39–S48
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) RIFM fragrance ingredient safety assessment, l-carvone, CAS registry number 6485-40-1. Food Chem Toxicol 163:112975
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) RIFM fragrance ingredient safety assessment, dl-limonene (racemic), CAS registry number 138-86-3. Food Chem Toxicol 161:112764
Api AM, Belsito D, Bhatia S, Bruze M, Calow P, Dagli ML, Dekant W, Fryer AD, Kromidas L, La Cava S, Lalko JF, Lapczynski A, Liebler DC, Miyachi Y, Politano VT, Ritacco G, Salvito D, Shen J, Schultz TW, Sipes IG, Wall B, Wilcox DK (2015) RIFM fragrance ingredient safety assessment, linalyl acetate, CAS registry number 115-95-7. Food Chem Toxicol 82:S39–S48
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Cancellieri MA, Chon H, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) RIFM fragrance ingredient safety assessment, menthol, CAS registry number 89-78-1. Food Chem Toxicol 163:112927
Bhatia SP, Wellington GA, Cocchiara J, Lalko J, Letizia CS, Api AM (2007) Fragrance material review on methyl cinnamate. Food Chem Toxicol 45:S113–S119
Api AM, Belsito D, Bhatia S, Botelho D, Browne D, Bruze M, Burton GA, Buschmann J, Calow P, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Joshi K, Kromidas L, La Cava S, Lalko JF, Lapczynski A, Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Politano VT, Ritacco G, Romine J, Salvito D, Schultz TW, Shen J, Sipes IG, Thakkar Y, Tsang S, Wahler J, Wall B, Wilcox DK (2017) RIFM fragrance ingredient safety assessment, methyl jasmonate, CAS registry number 1211-29-6. Food Chem Toxicol 110:S104–S113
Api AM, Belmonte F, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S (2020) RIFM fragrance ingredient safety assessment, myrcene, CAS registry number 123-35-3. Food Chem Toxicol 144:111631
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S (2020) RIFM fragrance ingredient safety assessment, phenylacetaldehyde, CAS registry number 122-78-1. Food Chem Toxicol 144:111658
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Cancellieri MA, Chon H, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) RIFM fragrance ingredient safety assessment, phenylacetic acid, CAS registry number 103-82-2. Food Chem Toxicol 167:113240
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S (2020) RIFM fragrance ingredient safety assessment, p-t-butyl-α-methylhydrocinnamic aldehyde, CAS registry number 80-54-6. Food Chem Toxicol 141:111430
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2021) RIFM fragrance ingredient safety assessment, pulegone, CAS registry number 89-82-7. Food Chem Toxicol 149:112092
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) RIFM fragrance ingredient safety assessment, α-cyclohexylidene benzeneacetonitrile, CAS registry number 10461-98-0. Food Chem Toxicol 159:112708
Api AM, Belsito D, Bhatia S, Bruze M, Calow P, Dagli ML, Dekant W, Fryer AD, Kromidas L, La Cava S, Lalko JF, Lapczynski A, Liebler DC, Miyachi Y, Politano VT, Ritacco G, Salvito D, Schultz TW, Shen J, Sipes IG, Wall B, Wilcox DK (2016) RIFM fragrance ingredient safety assessment, α-ionone, CAS registry number 127-41-3. Food Chem Toxicol 97:S1–S10
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2022) RIFM fragrance ingredient safety assessment, α-pinene, CAS registry number 80-56-8. Food Chem Toxicol 159:112702
Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y (2021) RIFM fragrance ingredient safety assessment, δ-decalactone, CAS registry number 705-86-2. Food Chem Toxicol 153:112142
Safford B, Api AM, Barratt C, Comiskey D, Daly EJ, Ellis G, McNamara C, O’Mahony C, Robison S, Smith B, Thomas R, Tozer S (2015) Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products. Regul Toxicol Pharmacol 72:673–682
Srinivasulu M, Chandra MS, Gooty JM, Madhavi A (2022) Chapter 8 – personal care products – fragrances, cosmetics, and sunscreens – in the environment. In: Hashmi MZ, Wang S, Ahmed Z (eds) Advances in pollution research, environmental micropollutants. Elsevier, pp 131–149
Homem V, Llompart M, Vila M, Ribeiro ARL, Garcia-Jares C, Ratola N, Celeiro M (2022) Gone with the flow – assessment of personal care products in Portuguese rivers. Chemosphere 293:133552
IFRA (2022) The complete IFRA standards up to and including the 50th amendment. Available at https://ifrafragrance.org/docs/default-source/ifra-code-of-practice-and-standards/ifra-standards%2D%2D-50th-amendment/standards-compiled.pdf?sfvrsn=87deb890_4. Accessed 24 Oct 2022
European Commission (2006) Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. OJ L 396:1–849
European Commission (2009) Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products. OJ L 342:59–209
European Commission (2021) Revision of the cosmetic products regulation (EC No 1223/2009) following the EU chemicals strategy for sustainability. https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELLAR:3b63422e-2c4c-11ec-bd8e-01aa75ed71a1. Accessed 25 Oct 2022
Bridges B (2002) Fragrance: emerging health and environmental concerns. Flavour Fragr J 17:361–371
FDA (2022) FDA authority over cosmetics: how cosmetics are not FDA-approved, but are FDA-regulated. https://www.fda.gov/cosmetics/cosmetics-laws-regulations/fda-authority-over-cosmetics-how-cosmetics-are-not-fda-approved-are-fda-regulated. Accessed 25 Oct 2022
FDA (2022) Cosmetics labelling regulations. https://www.fda.gov/cosmetics/cosmetics-labeling/cosmetics-labeling-regulations. Accessed 25 Oct 2022
Herman SJ (2004) Applications II: fragrance. In: Rowe DJ (ed) Chemistry and technology of flavors and fragrances. Blackwell Publishing, Bodmin, pp 305–329
Chisvert A, López-Nogueroles M, Salvador A (2019) Perfumes. In: Worsfold P, Poole C, Townshend A, Miró M (eds) Encyclopedia of analytical science3rd edn. Academic Press, pp 158–163
Steinemann A (2021) The fragranced products phenomenon: air quality and health, science and policy. Air Qual Atmos Health 14:235–243
Pastor-Nieto MA, Gatica-Ortega ME (2021) Ubiquity, hazardous effects, and risk assessment of fragrances in consumer products. Curr Treat Options Allergy 8:21–41
Perinelli DR, Palmieri GF, Cespi M, Bonacucina G (2020) Encapsulation of flavours and fragrances into polymeric capsules and cyclodextrins inclusion complexes: an update. Molecules 25:5878
Godinho RB, Santos MC, Poppi RJ (2016) Determination of fragrance content in perfume by Raman spectroscopy and multivariate calibration. Spectrochim Acta A Mol Biomol Spectrosc 157:158–163
Steinemann A (2017) Ten questions concerning air fresheners and indoor built environments. Build Environ 111:279–284
Uhde E, Schulz N (2015) Impact of room fragrance products on indoor air quality. Atmos Environ 106:492–502
Lin TC, Krishnaswamy G, Chi DS (2008) Incense smoke: clinical, structural and molecular effects on airway disease. Clin Mol Allergy 6:3
Mamusa M, Resta C, Sofroniou C, Baglioni P (2021) Encapsulation of volatile compounds in liquid media: fragrances, flavors, and essential oils in commercial formulations. Adv Colloid Interface Sci 298:102544
Herz RS, Larsson M, Trujillo R, Casola CC, Ahmed FK, Lipe S, Brashear ME (2022) A three-factor benefits framework for understanding consumer preference for scented household products: psychological interactions and implications for future development. Cogn Res: Princ Implic 7:28
FDA (2022) Fragrances in cosmetics. https://www.fda.gov/cosmetics/cosmetic-ingredients/fragrances-cosmetics. Accessed 26 Oct 2022
Grand View Research (2020) Fragrance fixatives market – long-lasting scent, long-lasting demand. https://www.grandviewresearch.com/blog/fragrance-fixatives-market-size-outlook. Accessed 28 Oct 2022
Wei M, Pan X, Rong L, Dong A, He Y, Song X, Li J (2020) Polymer carriers for controlled fragrance release. Mater Res Express 7:082001
Klaschka U, Kolossa-Gehring M (2007) Fragrances in the environment: pleasant odours for nature? Environ Sci Pollut Res Int 14:44–52
Patel S (2017) Fragrance compounds: the wolves in sheep’s clothings. Med Hypotheses 102:106–111
Cai Y, Lin J, Gimeno S, Begnaud F, Nowack B (2022) Country-specific environmental risks of fragrance encapsulates used in laundry care products. Environ Toxicol Chem 41(4):905–916
Khalid M, Abdollahi M (2021) Environmental distribution of personal care products and their effects on human health. Iran J Pharm Res 20(1):216–253
Vallecillos L, Borrul F, Pocurull E (2015) Recent approaches for the determination of synthetic musk fragrances in environmental samples. Trends Anal Chem 72:80–92
Homem V, Silva JA, Ratola N, Santos L, Alves A (2015) Long lasting perfume – a review of synthetic musks in WWTPs. J Environ Manage 149:168–192
Vecchiato M, Cremonese S, Gregoris E, Barbaro E, Gambaroo A, Barbante C (2016) Fragrance as new contaminants in the Venice lagoon. Sci Total Environ 566–567:1362–1367
Vecchiato M, Gregoris E, Barbaro E, Barbante C, Piazza R, Gambaro A (2017) Fragrances in the seawater of Terra Nova Bay, Antarctica. Sci Total Environ 593–594:375–379
Vecchiato M, Turetta C, Patti B, Barbante C, Piazza R, Bonato T, Gambaro A (2018) Distribution of fragrances and PAHs in the surface seawater of the Sicily Channel, Central Mediterranean. Sci Total Environ 634:983–989
Vecchiato M, Barbaro E, Spolaor A, Burgay F, Barbante C, Piazza R, Gambaro A (2018) Fragrances and PAHs in snow and seawater of Ny-Ålesund (Svalbard): local and long-range contamination. Environ Pollut 242(B):1740–1747
Vecchiato M, Gambaro A, Kehrwald NM, Ginot P, Kutuzov S, Mikhalenko V, Barbante C (2020) The great acceleration of fragrances and PAHs archived in an ice core from Elbrus. Caucasus Sci Rep 10:10661
Salvito DT, Senna RJ, Federle T (2009) A framework for prioritizing fragrance materials for aquatic risk assessment. Environ Toxicol Chem 21:1301–1308
Ravichandran J, Karthikeyan AS, Jost J, Samal A (2022) An atlas of fragrance chemicals in children’s products. Sci Total Environ 818:151682
Pinkas A, Gonçalves CL, Aschner M (2017) Neurotoxicity of fragrance compounds: a review. Environ Res 158:342–349
Acknowledgments
This work was financially supported by: (1) LA/P/0045/2020 (AliCE) and UIDB/00511/2020 – UIDP/00511/2020 (LEPABE) funded by national funds through FCT/MCTES (PIDDAC); (2) Project ‘HealthyWaters – Identification, Elimination, Social Awareness and Education of Water Chemical and Biological Micropollutants with Health and Environmental Implications’, with reference NORTE-01-0145-FEDER-000069, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); (3) Project ‘S4Hort_Soil&Food’ – Sustainable practices for Soil health & horticultural products quality improvement in the Entre Douro e Minho Region, with reference NORTE-01-0145-FEDER-000074, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); (4) PhD grant (ref 2020.09041.BD, Filipe Rocha), financed by FCT with funds from the State Budget, and by the European Social Fund (ESF) within the framework of PORTUGAL 2020, namely through NORTE 2020; (5) Vera Homem thanks national funds through FCT – Fundação para a Ciência e a Tecnologia, I.P., under the Scientific Employment Stimulus – Individual Call – CEECIND/00676/2017.
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Rocha, F., Ratola, N., Homem, V. (2023). Fragrances in the Environment: Properties, Applications, and Emissions. In: Ratola, N., Homem, V. (eds) Fragrances in the Environment. The Handbook of Environmental Chemistry, vol 128. Springer, Cham. https://doi.org/10.1007/698_2023_983
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