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Identifying Emerging Pollutants Using Non-target or Wide-Screening Liquid Chromatography-Mass Spectrometry

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Emerging Pollutants in Sewage Sludge and Soils

Part of the book series: The Handbook of Environmental Chemistry ((HEC,volume 114))

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Abstract

In this chapter we review the available data on the application of non-targeted high-resolution mass spectrometry (HRMS) analysis to identify a wide range of substances (mainly emerging pollutants) present in sludge. We focus on non-targeted workflows developed with these instruments: (1) the screening of suspects or broad screening and (2) the analysis of unknown compounds providing a fingerprint of almost all chemical contaminants present in sludge. The different workflows as well as their achievements and pitfalls within the identification of chemicals in sludge are discussed in depth. The pre-treatment of sludge (decisive for the detection of compounds) is also discussed since it cannot be avoided due to the complexity of the sample.

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References

  1. Biel-Maeso M, Corada-Fernández C, Lara-Martín PA (2019) Removal of personal care products (PCPs) in wastewater and sludge treatment and their occurrence in receiving soils. Water Res 150:129–139. https://doi.org/10.1016/j.watres.2018.11.045

    Article  CAS  Google Scholar 

  2. Buta M, Hubeny J, Zieliński W, Harnisz M, Korzeniewska E (2021) Sewage sludge in agriculture – the effects of selected chemical pollutants and emerging genetic resistance determinants on the quality of soil and crops – a review. Ecotoxicol Environ Saf 214:112070. https://doi.org/10.1016/j.ecoenv.2021.112070

  3. Malvar JL, Santos JL, Martín J, Aparicio I, Alonso E (2021) Occurrence of the main metabolites of the most recurrent pharmaceuticals and personal care products in Mediterranean soils. J Environ Manag 278:111584. https://doi.org/10.1016/j.jenvman.2020.111584

  4. BOE (1990) Real Decreto 1310/1990, de 29 de octubre, por el que se regula la utilización de los lodos de depuración en el sector agrario. Span State Off Bull 262:2

    Google Scholar 

  5. Vazquez-Roig P, Andreu V, Onghena M, Blasco C, Picó Y (2011) Assessment of the occurrence and distribution of pharmaceuticals in a Mediterranean wetland (L'Albufera, Valencia, Spain) by LC-MS/MS. Anal Bioanal Chem 400:1287–1301. https://doi.org/10.1007/s00216-011-4826-5

    Article  CAS  Google Scholar 

  6. Campo J, Masiá A, Picó Y, Farré M, Barceló D (2014) Distribution and fate of perfluoroalkyl substances in Mediterranean Spanish sewage treatment plants. Sci Total Environ 472:912–922. https://doi.org/10.1016/j.scitotenv.2013.11.056

    Article  CAS  Google Scholar 

  7. Llorca M, Farré M, Picó Y, Barceló D (2011) Analysis of perfluorinated compounds in sewage sludge by pressurized solvent extraction followed by liquid chromatography-mass spectrometry. J Chromatogr A 1218:4840–4846. https://doi.org/10.1016/j.chroma.2011.01.085

    Article  CAS  Google Scholar 

  8. Martín-Pozo L, de Alarcón-Gómez B, Rodríguez-Gómez R, García-Córcoles MT, Çipa M, Zafra-Gómez A (2019) Analytical methods for the determination of emerging contaminants in sewage sludge samples. A review. Talanta 192:508–533. https://doi.org/10.1016/j.talanta.2018.09.056

    Article  CAS  Google Scholar 

  9. Silva S, Rodrigues JA, Coelho MR, Martins A, Cardoso E, Cardoso VV et al (2021) Occurrence of pharmaceutical active compounds in sewage sludge from two urban wastewater treatment plants and their potential behaviour in agricultural soils. Environ Sci Water Res Technol 7:969–982. https://doi.org/10.1039/d1ew00132a

    Article  CAS  Google Scholar 

  10. Picó Y, Barceló D (2015) Transformation products of emerging contaminants in the environment and high-resolution mass spectrometry: a new horizon. Anal Bioanal Chem 407:6257–6273. https://doi.org/10.1007/s00216-015-8739-6

    Article  CAS  Google Scholar 

  11. Black GP, Anumol T, Young T, M. (2019) Analyzing a broader spectrum of endocrine active organic contaminants in sewage sludge with high resolution LC-QTOF-MS suspect screening and QSAR toxicity prediction. Environ Sci: Processes Impacts 21:1099–1114. https://doi.org/10.1039/C9EM00144A

    Article  CAS  Google Scholar 

  12. Black GP, He G, Denison MS, Young TM (2021) Using estrogenic activity and nontargeted chemical analysis to identify contaminants in sewage sludge. Environ Sci Technol 55:6729–6739. https://doi.org/10.1021/acs.est.0c07846

    Article  CAS  Google Scholar 

  13. Aalizadeh R, Nika MC, Thomaidis NS (2019) Development and application of retention time prediction models in the suspect and non-target screening of emerging contaminants. J Hazard Mater 363:277–285. https://doi.org/10.1016/j.jhazmat.2018.09.047

    Article  CAS  Google Scholar 

  14. Boix C, Ibáñez M, Fabregat-Safont D, Morales E, Pastor L, Sancho JV et al (2016) Behaviour of emerging contaminants in sewage sludge after anaerobic digestion. Chemosphere 163:296–304. https://doi.org/10.1016/j.chemosphere.2016.07.098

    Article  CAS  Google Scholar 

  15. Martínez-Piernas AB, Plaza-Bolaños P, Agüera A (2021) Assessment of the presence of transformation products of pharmaceuticals in agricultural environments irrigated with reclaimed water by wide-scope LC-QTOF-MS suspect screening. J Hazard Mater 412:125080. https://doi.org/10.1016/j.jhazmat.2021.125080

  16. Castro G, Ramil M, Cela R, Rodríguez I (2021) Identification and determination of emerging pollutants in sewage sludge driven by UPLC-QTOF-MS data mining. Sci Total Environ 778:146256. https://doi.org/10.1016/j.scitotenv.2021.146256

    Article  CAS  Google Scholar 

  17. Chiaia-Hernández AC, Scheringer M, Müller A, Stieger G, Wächter D, Keller A et al (2020) Target and suspect screening analysis reveals persistent emerging organic contaminants in soils and sediments. Sci Total Environ 740:140181. https://doi.org/10.1016/j.scitotenv.2020.140181

    Article  CAS  Google Scholar 

  18. Gravert TKO, Vuaille J, Magid J, Hansen M (2021) Non-target analysis of organic waste amended agricultural soils: characterization of added organic pollution. Chemosphere 280:130582. https://doi.org/10.1016/j.chemosphere.2021.130582

  19. Pérez-Lemus N, López-Serna R, Pérez-Elvira SI, Barrado E (2019) Analytical methodologies for the determination of pharmaceuticals and personal care products (PPCPs) in sewage sludge: a critical review. Anal Chim Acta 1083:19–40. https://doi.org/10.1016/j.aca.2019.06.044

    Article  CAS  Google Scholar 

  20. García Valverde M, Martínez Bueno MJ, Gómez-Ramos MM, Aguilera A, Gil García MD, Fernández-Alba AR (2021) Determination study of contaminants of emerging concern at trace levels in agricultural soil. A pilot study. Sci Total Environ 782:146759. https://doi.org/10.1016/j.scitotenv.2021.146759

    Article  CAS  Google Scholar 

  21. Andrés-Costa MJ, Andreu V, Picó Y (2017) Liquid chromatography–mass spectrometry as a tool for wastewater-based epidemiology: assessing new psychoactive substances and other human biomarkers. TrAC Trends Anal Chem 94:21–38. https://doi.org/10.1016/j.trac.2017.06.012

    Article  CAS  Google Scholar 

  22. Boix C, Ibáñez M, Fabregat-Safont D, Morales E, Pastor L, Sancho JV et al (2016) Analytical methodologies based on LC-MS/MS for monitoring selected emerging compounds in liquid and solid phases of the sewage sludge. MethodsX 3:333–342. https://doi.org/10.1016/j.mex.2016.04.010

    Article  CAS  Google Scholar 

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Acknowledgements

Funding: The research received funding from the Spanish Ministry of Science, Innovation and Universities and the European Regional Development Fund through the project CICLIC (RTI2018-097158-B-C31) and from the Generalitat Valenciana through the project ANTROPOCEN@ (PROMETEO/2018/155).

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Correspondence to Yolanda Picó .

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Vitale, D., Andreu, V., Picó, Y. (2022). Identifying Emerging Pollutants Using Non-target or Wide-Screening Liquid Chromatography-Mass Spectrometry. In: Núñez-Delgado, A., Arias-Estévez, M. (eds) Emerging Pollutants in Sewage Sludge and Soils. The Handbook of Environmental Chemistry, vol 114. Springer, Cham. https://doi.org/10.1007/698_2022_856

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