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Bioavailability of Organic Chemicals in Soil and Sediment pp 191–218Cite as

Assessment of the Oral Bioavailability of Organic Contaminants in Humans

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Part of the The Handbook of Environmental Chemistry book series (HEC,volume 100)

Abstract

Bioavailability estimates the actual internal uptake or absorption of contaminants that enter the body (internal dose) and helps in providing a more accurate estimation of the human risks than the usage of total concentration. This is important for exposure assessment for children in relation to their hand-to-mouth activities. For example significant reductions of the bioavailability of long-term contaminated soils have been demonstrated using various animal models. The measurement for bioavailability involves various uncertainties for organic contaminants. It is crucial to determine the parameters that influence the results of bioavailability. This chapter provides a summary of the current state of knowledge for the determination of bioavailability for a range of organic contaminants. The information provided will be useful in facilitating further research efforts for the investigation of bioavailability of contaminants in conducting exposure assessments.

Keywords

  • Bioaccumulation
  • Bioavailability
  • Diffusion
  • Dissolution
  • Electrophilic
  • Perfusion rate
  • Permeability rate

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Authors and Affiliations

  1. Global Centre for Environmental Remediation (GCER), University of Newcastle, Callaghan, NSW, Australia

    M. A. A. Wijayawardena, Y. Liu, K. Yan, L. Duan, A. C. Umeh & R. Naidu

  2. Cooperative Research Centre for Contamination Assessment and Remediation of the Environment (CRC CARE), ATC Building, University of Newcastle, Callaghan, NSW, Australia

    M. A. A. Wijayawardena, Y. Liu, K. Yan, L. Duan, A. C. Umeh & R. Naidu

  3. Lancaster Environment Centre, Lancaster University, Lancaster, UK

    K. T. Semple

Authors
  1. M. A. A. Wijayawardena
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  2. Y. Liu
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  3. K. Yan
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  4. L. Duan
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  5. A. C. Umeh
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  7. K. T. Semple
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Correspondence to R. Naidu .

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Editors and Affiliations

  1. Instituto de Recursos Naturales y AgrobiobiologÚa de Sevilla, CSIC, Seville, Spain

    Jose Julio Ortega-Calvo

  2. Institute for Biodiversity & Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands

    Prof. John Robert Parsons

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Wijayawardena, M.A.A. et al. (2020). Assessment of the Oral Bioavailability of Organic Contaminants in Humans. In: Ortega-Calvo, J.J., Parsons, J.R. (eds) Bioavailability of Organic Chemicals in Soil and Sediment. The Handbook of Environmental Chemistry, vol 100. Springer, Cham. https://doi.org/10.1007/698_2020_596

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