Abstract
Global water quantity and quality are anticipated to decrease in the coming decades, as a result of both increasing global populations and the effects of climate change. Reusing and recycling water is a key part of reducing the pressure on our existing water supplies and the aquatic environment. However, the occurrence of nonsteroidal anti-inflammatory drugs (NSAIDs) in secondary, and in some tertiary, treated effluents- and sewage-impacted water bodies is one of the major obstacles for the implementation of water reuse. For several decades, NSAIDs have been extensively used for therapeutic purposes in both humans and domestic livestock. The negative effects of NSAIDs on aquatic biota are just beginning to be realized. Currently, intensive treatments are required to remove effectively NSAIDs from recycled treated effluent in order to minimize or eliminate risks to human health and aquatic environment. In this chapter, we focus the discussion on contemporary methods for NSAID removal including biological, physical, chemical, and combined process that may provide a more effective and efficient alternative.
Keywords
- Advanced oxidation process
- Integrated process
- Membrane process
- NSAIDs
- Water reuse
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References
Day RO, Graham GG (2013) Non-steroidal anti-inflammatory drugs (NSAIDs). BMJ Br Med J 346:f3195
Sutherland DL, Ralph PJ (2019) Microalgal bioremediation of emerging contaminants – opportunities and challenges. Water Res 164:114921
Tran NH, Reinhard M, Gin KY-H (2018) Occurrence and fate of emerging contaminants in municipal wastewater treatment plants from different geographical regions – a review. Water Res 133:182–207
Nguyen LN, Nghiem LD, Pramanik BK, Oh S (2018) Cometabolic biotransformation and impacts of the anti-inflammatory drug diclofenac on activated sludge microbial communities. Sci Total Environ
Clara M, Strenn B, Gans O, Martinez E, Kreuzinger N, Kroiss H (2005) Removal of selected pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants. Water Res 39(19):4797–4807
Jewell KS, Falås P, Wick A, Joss A, Ternes TA (2016) Transformation of diclofenac in hybrid biofilm-activated sludge processes. Water Res 105:559–567
Nguyen LN, Nghiem LD, Pramanik BK, Oh S (2019) Cometabolic biotransformation and impacts of the anti-inflammatory drug diclofenac on activated sludge microbial communities. Sci Total Environ 657:739–745
Kimura K, Amy G, Drewes JE, Heberer T, Kim T-U, Watanabe Y (2003) Rejection of organic micropollutants (disinfection by-products, endocrine disrupting compounds, and pharmaceutically active compounds) by NF/RO membranes. J Membr Sci 227(1–2):113–121
Tran NH, Urase T, Kusakabe O (2010) Biodegradation characteristics of pharmaceutical substances by whole fungal culture Trametes versicolor and its laccase. J Water Environ Technol 8(2):125–140
Cui Y-W, Zhang H-Y, Lu P-F, Peng Y-Z (2016) Effects of carbon sources on the enrichment of halophilic polyhydroxyalkanoate-storing mixed microbial culture in an aerobic dynamic feeding process. Nat Rep 3:1–13
Wei Y, Liao S-A, Wang A-l (2016) The effect of different carbon sources on the nutritional composition, microbial community and structure of bioflocs. Aquaculture 465:88–93
Tran NH, Urase T, Ngo HH, Hu J, Ong SL (2013) Insight into metabolic and cometabolic activities of autotrophic and heterotrophic microorganisms in the biodegradation of emerging trace organic contaminants. Bioresour Technol 146:721–731
Radjenovic J, Petrovic M, Barceló D (2007) Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor. Anal Bioanal Chem 387(4):1365–1377
Joss A, Zabczynski S, Göbel A, Hoffmann B, Löffler D, McArdell CS, Ternes TA, Thomsen A, Siegrist H (2006) Biological degradation of pharmaceuticals in municipal wastewater treatment: proposing a classification scheme. Water Res 40(8):1686–1696
Bérubé P, Isabel CE, Andrea IS (2010) Escobar CI, Andrea IS (eds) Sustainability science and engineering. Elsevier, Amsterdam, pp 255–292
González S, Müller J, Petrovic M, Barceló D, Knepper TP (2006) Biodegradation studies of selected priority acidic pesticides and diclofenac in different bioreactors. Environ Pollut 144(3):926–932
Petrovic M, Gonzalez S, Barceló D (2003) Analysis and removal of emerging contaminants in wastewater and drinking water. TrAC Trends Anal Chem 22(10):685–696
Snyder SA, Adham S, Redding AM, Cannon FS, DeCarolis J, Oppenheimer J, Wert EC, Yoon Y (2007) Role of membranes and activated carbon in the removal of endocrine disruptors and pharmaceuticals. Desalination 202(1–3):156–181
Tadkaew N, Hai FI, McDonald JA, Khan SJ, Nghiem LD (2011) Removal of trace organics by MBR treatment: the role of molecular properties. Water Res 45(8):2439–2451
Hai FI, Tessmer K, Nguyen LN, Kang J, Price WE, Nghiem LD (2011) Removal of micropollutants by membrane bioreactor under temperature variation. J Membr Sci 383(1):144–151
Nguyen LN, Hai FI, Kang J, Nghiem LD, Price WE, Guo W, Ngo HH, Tung K-L (2013) Comparison between sequential and simultaneous application of activated carbon with membrane bioreactor for trace organic contaminant removal. Bioresour Technol 130:412–417
Nguyen LN, Hai FI, Yang S, Kang J, Leusch FDL, Roddick F, Price WE, Nghiem LD (2013) Removal of trace organic contaminants by an MBR comprising a mixed culture of bacteria and white-rot fungi. Bioresour Technol 148:234–241
Trinh T, van den Akker B, Stuetz RM, Coleman HM, Le-Clech P, Khan SJ (2012) Removal of trace organic chemical contaminants by a membrane bioreactor. Water Sci Technol 66(9):1856–1863
Cirja M, Ivashechkin P, Schäffer A, Corvini PFX (2008) Factors affecting the removal of organic micropollutants from wastewater in conventional treatment plants (CTP) and membrane bioreactors (MBR). J Rev Environ Sci Biotechnol 7(1):61–78
Hai FI, Tadkaew N, McDonald JA, Khan SJ, Nghiem LD (2011) Is halogen content the most important factor in the removal of halogenated trace organics by MBR treatment? Bioresour Technol 102(10):6299–6303
Hai FI, Nghiem LD, Modin O (2013) In: Basile A (ed) Handbook of membrane reactors volume 2: reactor types and industrial application. Woodhead Publishing, Cambridge, pp 763–807
Kudanga T, Prasetyo EN, Widsten P, Kandelbauer A, Jury S, Heathcote C, Sipilä J, Weber H, Nyanhongo GS, Guebitz GM (2010) Laccase catalyzed covalent coupling of fluorophenols increases lignocellulose surface hydrophobicity. Bioresour Technol 101(8):2793–2799
Modin O, Hai FI, Nghiem LD, Basile A, Fukushi K (2014) In: Hai FI, Yamamoto K, Lee C-H (eds) Membrane biological reactors. IWA Publishing, London, pp 300–333
Yang S, Hai FI, Nghiem LD, Price WE, Roddick F, Moreira MT, Magram SF (2013) Understanding the factors controlling the removal of trace organic contaminants by white-rot fungi and their lignin modifying enzymes: a critical review. Bioresour Technol 141:97–108
Unuofin JO, Okoh AI, Nwodo UU (2019) Aptitude of oxidative enzymes for treatment of wastewater pollutants: a Laccase perspective. Molecules 24(11):2064
Ashe B, Nguyen LN, Hai FI, Lee D-J, van de Merwe JP, Leusch FDL, Price WE, Nghiem LD (2016) Impacts of redox-mediator type on trace organic contaminants degradation by laccase: degradation efficiency, laccase stability and effluent toxicity. Int Biodeterior Biodegradation 113:169–176
Nguyen LN, Hai FI, Price WE, Leusch FDL, Roddick F, McAdam EJ, Magram SF, Nghiem LD (2014) Continuous biotransformation of bisphenol A and diclofenac by laccase in an enzymatic membrane reactor. Int Biodeterior Biodegradation 95:25–32
Kim Y-J, Nicell JA (2006) Laccase catalysed oxidation of aqueous triclosan. J Chem Technol Biotechnol 81:1344–1352
Hai FI, Yamamoto K, Nakajima F, Fukushi K (2012) Application of a GAC-coated hollow fiber module to couple enzymatic degradation of dye on membrane to whole cell biodegradation within a membrane bioreactor. J Membr Sci 389:67–75
Brugnari T, Pereira MG, Bubna GA, de Freitas EN, Contato AG, Corrêa RCG, Castoldi R, de Souza CGM, Polizeli MdLTdM, Bracht A, Peralta RM (2018) A highly reusable MANAE-agarose-immobilized Pleurotus ostreatus laccase for degradation of bisphenol A. Sci Total Environ 634:1346–1351
Margot J, Bennati-Granier C, Maillard J, Blánquez P, Barry DA, Holliger C (2013) Bacterial versus fungal laccase: potential for micropollutant degradation. AMB Express 3(1):63–63
Lloret L, Eibes G, Feijoo G, Moreira MT, Lema JM (2012) Degradation of estrogens by laccase from Myceliophthora thermophila in fed-batch and enzymatic membrane reactors. J Hazard Mater 213–214:175–183
Cabana H, Jones JP, Agathos SN (2009) Utilization of cross-linked laccase aggregates in a perfusion basket reactor for the continuous elimination of endocrine-disrupting chemicals. Biotechnol Bioeng 102(6):1582–1592
Rios GM, Belleville MP, Paolucci D, Sanchez J (2004) Progress in enzymatic membrane reactors – a review. J Membr Sci 242(1–2):189–196
Andersson MM, Breccia JD, Hatti-Kaul R (2000) Stabilizing effect of chemical additives against oxidation of lactate dehydrogenase. Biotechnol Appl Biochem 32(3):145–153
Mendoza L, Jonstrup M, Hatti-Kaul R, Mattiasson B (2011) Azo dye decolorization by a laccase/mediator system in a membrane reactor: enzyme and mediator reusability. Enzym Microb Technol 49(5):478–484
Xiong JQ, Kurade MB, Jeon BH (2018) Can microalgae remove pharmaceutical contaminants from water? Trends Biotechnol 36(1):30–44
Coimbra RN, Escapa C, Vázquez NC, Noriega-Hevia G, Otero M (2018) Utilization of non-living microalgae biomass from two different strains for the adsorptive removal of diclofenac from water. Water 10:1401
Zhang H, Yamada H, Tsuno H (2008) Removal of endocrine-disrupting chemicals during ozonation of municipal sewage with brominated byproducts control. Environ Sci Technol 42(9):3375–3380
Escapa A, Mateos R, Martínez E, Blanes J (2016) Microbial electrolysis cells: an emerging technology for wastewater treatment and energy recovery. From laboratory to pilot plant and beyond. Renew Sustain Energy Rev 55:942–956
Ding T, Lin K, Yang B et al (2017) Biodegradation of naproxen by freshwater algae Cymbella sp. and Scenedesmus quadricauda and the comparative toxicity. Bioresour Technol 238:164–173
Marco-Urrea E, Perez-Trujillo M, Blanquez P, Vicent T, Caminal G (2010) Biodegradation of the analgesic naproxen by Trametes versicolor and identification of intermediates using HPLC-DAD-MS and NMR. Bioresour Technol 101(7):2159–2166
Olicón-Hernández DR, González-López J, Aranda E (2017) Overview on the biochemical potential of filamentous Fungi to degrade pharmaceutical compounds. Front Microbiol 8:1792
Domaradzka D, Guzik U, Wojcieszyńska D (2015) Biodegradation and biotransformation of polycyclic non-steroidal anti-inflammatory drugs. Rev Environ Sci Biotechnol 14(2):229–239
Otto B, Beuchel C, Liers C, Reisser W, Harms H, Schlosser D (2015) Laccase-like enzyme activities from chlorophycean green algae with potential for bioconversion of phenolic pollutants. FEMS Microbiol Lett 362(11)
Zhang J, Ma F, Zhang X, Geng A (2018) Directed evolution of a homodimeric laccase from Cerrena unicolor BBP6 by random mutagenesis and in vivo assembly. Int J Mol Sci 19(10)
Rasala BA, Mayfield SP (2015) Photosynthetic biomanufacturing in green algae; production of recombinant proteins for industrial, nutritional, and medical uses. Photosynth Res 123(3):227–239
Chiaiese P, Palomba F, Tatino F, Lanzillo C, Pinto G, Pollio A, Filippone E (2011) Engineered tobacco and microalgae secreting the fungal laccase POXA1b reduce phenol content in olive oil mill wastewater. Enzym Microb Technol 49(6–7):540–546
Matamoros V, Gutiérrez R, Ferrer I, García J, Bayona JM (2015) Capability of microalgae-based wastewater treatment systems to remove emerging organic contaminants: a pilot-scale study. J Hazard Mater 288:34–42
Norvill ZN, Shilton A, Guieysse B (2016) Emerging contaminant degradation and removal in algal wastewater treatment ponds: Identifying the research gaps. J Hazard Mater 313:291–309
Villar-Navarro E, Baena-Nogueras RM, Paniw M, Perales JA, Lara-Martín PA (2018) Removal of pharmaceuticals in urban wastewater: high rate algae pond (HRAP) based technologies as an alternative to activated sludge based processes. Water Res 139:19–29
Cajthaml T, Křesinová Z, Svobodová K, Möder M (2009) Biodegradation of endocrine-disrupting compounds and suppression of estrogenic activity by ligninolytic fungi. Chemosphere 75:745–750
Azbar N, Yonar T, Kestioglu K (2004) Comparison of various advanced oxidation processes and chemical treatment methods for COD and color removal from a polyester and acetate fiber dyeing effluent. Chemosphere 55(1):35–43
Andreozzi R, Campanella L, Fraysse B, Garric J, Gonnella A, Giudice RL, Marotta R, Pinto G, Pollio A (2004) Effects of advanced oxidation processes (AOPs) on the toxicity of a mixture of pharmaceuticals. Water Sci Technol 50(5):23–28
Contreras S, Rodríguez M, Momani FA, Sans C, Esplugas S (2003) Contribution of the ozonation pre-treatment to the biodegradation of aqueous solutions of 2,4-dichlorophenol. Water Res 37(13):3164–3171
Esplugas S, Giménez J, Contreras S, Pascual E, Rodríguez M (2002) Comparison of different advanced oxidation processes for phenol degradation. Water Res 36(4):1034–1042
Klavarioti M, Mantzavinos D, Kassinos D (2009) Removal of residual pharmaceuticals from aqueous systems by advanced oxidation processes. Environ Int 35(2):402–417
Ternes TA, Stüber J, Herrmann N, McDowell D, Ried A, Kampmann M, Teiser B (2003) Ozonation: a tool for removal of pharmaceuticals, contrast media and musk fragrances from wastewater? Water Res 37(8):1976–1982
Rizzo L, Malato S, Antakyali D, Beretsou VG, Đolić MB, Gernjak W, Heath E, Ivancev-Tumbas I, Karaolia P, Lado Ribeiro AR, Mascolo G, McArdell CS, Schaar H, Silva AMT, Fatta-Kassinos D (2019) Consolidated vs new advanced treatment methods for the removal of contaminants of emerging concern from urban wastewater. Sci Total Environ 655:986–1008
Lee Y, Gerrity D, Lee M, Bogeat AE, Salhi E, Gamage S, Trenholm RA, Wert EC, Snyder SA, von Gunten U (2013) Prediction of micropollutant elimination during ozonation of municipal wastewater effluents: use of kinetic and water specific information. Environ Sci Technol 47(11):5872–5881
Fujioka T, Khan SJ, McDonald JA, Nghiem LD (2014) Ozonation of N-nitrosamines in the reverse osmosis concentrate from water recycling applications. Ozone Sci Eng 36(2):174–180
Wert EC, Rosario-Ortiz FL, Snyder SA (2009) Effect of ozone exposure on the oxidation of trace organic contaminants in wastewater. Water Res 43(4):1005–1014
Maldonado MI, Malato S, Pérez-Estrada LA, Gernjak W, Oller I, Doménech X, Peral J (2006) Partial degradation of five pesticides and an industrial pollutant by ozonation in a pilot-plant scale reactor. J Hazard Mater 138(2):363–369
Yuan F, Hu C, Hu X, Qu J, Yang M (2009) Degradation of selected pharmaceuticals in aqueous solution with UV and UV/H2O2. Water Res 43(6):1766–1774
Comninellis C, Kapalka A, Malato S, Parsons SA, Poulios I, Mantzavinos D (2008) Advanced oxidation processes for water treatment: advances and trends for R&D. J Chem Technol Biotechnol 83(6):769–776
Agenson KO, Oh J-I, Urase T (2003) Retention of a wide variety of organic pollutants by different nanofiltration/reverse osmosis membranes: controlling parameters of process. J Membr Sci 225(1–2):91–103
Hofman JAMH, Gijsbertsen AJ, Cornelissen E (2007) Nanofiltration retention models for organic contaminants. Water Research Foundation, Denver, p 167
Nghiem LD, Schäfer AI (2002) Adsorption and transport of trace contaminant Estrone in NF/RO membranes. Environ Eng Sci 19(6):441–451
Vogel D, Simon A, Alturki AA, Bilitewski B, Price WE, Nghiem LD (2010) Effects of fouling and scaling on the retention of trace organic contaminants by a nanofiltration membrane: the role of cake-enhanced concentration polarisation. Sep Purif Technol 73(2):256–263
Xu P, Drewes JE, Kim T-U, Bellona C, Amy G (2006) Effect of membrane fouling on transport of organic contaminants in NF/RO membrane applications. J Membr Sci 279(1–2):165–175
Nghiem LD, Manis A, Soldenhoff K, Schäfer AI (2004) Estrogenic hormone removal from wastewater using NF/RO membranes. J Membr Sci 242(1):37–45
Nguyen LN, Hai FI, Kang J, Price WE, Nghiem LD (2013) Removal of emerging trace organic contaminants by MBR-based hybrid treatment processes. Int Biodeterior Biodegradation 85:474–482
Verliefde ARD, Heijman SGJ, Cornelissen ER, Amy GL, Van der Bruggen B, van Dijk JC (2008) Rejection of trace organic pollutants with high pressure membranes (NF/RO). Environ Prog 27(2):180–188
Nghiem LD (2005) Removal of emerging trace organic contaminants by nanofiltration and reverse osmosis. University of Wollongong, Wollongong
Agus E, Sedlak DL (2010) Formation and fate of chlorination by-products in reverse osmosis desalination systems. Water Res 44(5):1616–1626
Bellona C, Drewes JE, Xu P, Amy G (2004) Factors affecting the rejection of organic solutes during NF/RO treatment-a literature review. Water Res 38(12):2795–2809
Nghiem LD, Schäfer AI, Elimelech M (2004) Removal of natural hormones by nanofiltration membranes: measurement, modeling, and mechanisms. Environ Sci Technol 38(6):1888–1896
Steinle-Darling E, Litwiller E, Reinhard M (2010) Effects of sorption on the rejection of trace organic contaminants during nanofiltration. Environ Sci Technol 44:2592–2598
Xu P, Drewes JE, Bellona C, Amy G, Kim T-U, Adam M, Heberer T (2005) Rejection of emerging organic micropollutants in Nanofiltration-reverse osmosis membrane applications. Water Environ Res 77(1):40–48
Ben-David A, Bernstein R, Oren Y, Belfer S, Dosoretz C, Freger V (2010) Facile surface modification of nanofiltration membranes to target the removal of endocrine-disrupting compounds. J Membr Sci 357(1–2):152–159
Bellona C, Drewes JE (2005) The role of membrane surface charge and solute physico-chemical properties in the rejection of organic acids by NF membranes. J Membr Sci 249(1–2):227–234
Nghiem LD, Hawkes S (2007) Effects of membrane fouling on the nanofiltration of pharmaceutically active compounds (PhACs): mechanisms and role of membrane pore size. Sep Purif Technol 57(1):176–184
Sharma RR, Agrawal R, Chellam S (2003) Temperature effects on sieving characteristics of thin-film composite nanofiltration membranes: pore size distributions and transport parameters. J Membr Sci 223(1–2):69–87
Wei C-H, Zhang X-X, Ren Y, Yu X-B (2011) George A (ed) Biomimetic based applications. InTech, Croatia, pp 285–310
Binyam S, Mukhtar H, Leong LK (2009) Flux and rejection on monoethanolamine (MEA) in wastewater using membrane technology. IWTC, Hurghada, pp 139–151
Steinle-Darling E, Reinhard M (2008) Nanofiltration for trace organic contaminant removal: structure, solution, and membrane fouling effects on the rejection of Perfluorochemicals. Environ Sci Technol 42(14):5292–5297
Ng HY, Elimelech M (2004) Influence of colloidal fouling on rejection of trace organic contaminants by reverse osmosis. J Membr Sci 244(1–2):215–226
Alturki AA, Tadkaew N, McDonald JA, Khan SJ, Price WE, Nghiem LD (2010) Combining MBR and NF/RO membrane filtration for the removal of trace organics in indirect potable water reuse applications. J Membr Sci 365(1):206–215
Hai FI, Alturki A, Nguyen LN, Price WE, Nghiem LD (2016) Green technologies for sustainable water management. ASCE, Reston, pp 533–578
Comerton AM, Andrews RC, Bagley DM (2005) Evaluation of an MBR-RO system to produce high quality reuse water: microbial control, DBP formation and nitrate. Water Res 39(16):3982–3990
Dialynas E, Diamadopoulos E (2009) Integration of a membrane bioreactor coupled with reverse osmosis for advanced treatment of municipal wastewater. Desalination 238(1–3):302–311
Jacob M, Guigui C, Cabassud C, Darras H, Lavison G, Moulin L (2010) Performances of RO and NF processes for wastewater reuse: tertiary treatment after a conventional activated sludge or a membrane bioreactor. Desalination 250(2):833–839
Qin J-J, Kekre KA, Tao G, Oo MH, Wai MN, Lee TC, Viswanath B, Seah H (2006) New option of MBR-RO process for production of NEWater from domestic sewage. J Membr Sci 272(1–2):70–77
Tam LS, Tang TW, Lau GN, Sharma KR, Chen GH (2007) A pilot study for wastewater reclamation and reuse with MBR/RO and MF/RO systems. Desalination 202(1–3):106–113
Halim AA, Aziz HA, Johari MAM, Ariffin KS (2010) Comparison study of ammonia and COD adsorption on zeolite, activated carbon and composite materials in landfill leachate treatment. Desalination 262(1–3):31–35
Cook D, Newcombe G, Sztajnbok P (2001) The application of powdered activated carbon for mib and geosmin removal: predicting pac doses in four raw waters. Water Res 35(5):1325–1333
Mall ID, Srivastava VC, Agarwal NK, Mishra IM (2005) Removal of congo red from aqueous solution by bagasse fly ash and activated carbon: kinetic study and equilibrium isotherm analyses. Chemosphere 61(4):492–501
Singh KP, Mohan D, Sinha S, Tondon GS, Gosh D (2003) Color removal from wastewater using low-cost activated carbon derived from agricultural waste material. Ind Eng Chem Res 42(9):1965–1976
Yeh RY-L, Thomas A (1995) Color removal from dye wastewaters by adsorption using powdered activated carbon: mass transfer studies. J Chem Technol Biotechnol 63(1):48–54
Gamez V, Larrechi MS, Callao MP (2007) Kinetic and adsorption study of acid dye removal using activated carbon. Chemosphere 69(7):1151–1158
Hai FI, Yamamoto K, Nakajima F, Fukushi K (2008) Removal of structurally different dyes in submerged membrane fungi reactor – biosorption/PAC-adsorption, membrane retention and biodegradation. J Membr Sci 325(1):395–403
Matsui Y, Knappe DRU, Iwaki K, Ohira H (2002) Pesticide adsorption by granular activated carbon Adsorbers. 2. Effects of pesticide and natural organic matter characteristics on pesticide breakthrough curves. Environ Sci Technol 36(15):3432–3438
Kim SH, Shon HK, Ngo HH (2010) Adsorption characteristics of antibiotics trimethoprim on powdered and granular activated carbon. J Ind Eng Chem 16(3):344–349
Ternes TA, Meisenheimer M, McDowell D, Sacher F, Brauch H, Haist-Gulde B, Preuss G, Wilme U, Zulei-Seibert N (2002) Removal of pharmaceuticals during drinking water treatment. Environ Sci Technol 36(17):3855–3863
Hernández-Leal L, Temmink H, Zeeman G, Buisman CJN (2011) Removal of micropollutants from aerobically treated grey water via ozone and activated carbon. Water Res 45(9):2887–2896
Grover DP, Zhou JL, Frickers PE, Readman JW (2010) Improved removal of estrogenic and pharmaceutical compounds in sewage effluent by full scale granular activated carbon: impact on receiving river water. J Hazard Mater 185(2–3):1005–1011
Tanghe T, Verstraete W (2001) Adsorption of Nonylphenol onto granular activated carbon. Water Air Soil Pollut 131(1):61–72
Dickenson ERV, Drewes JE (2010) Quantitative structure property relationships for the adsorption of pharmaceuticals onto activated carbon. Water Sci Technol 62(10):2270–2276
Li X, Hai FI, Nghiem LD (2011) Simultaneous activated carbon adsorption within a membrane bioreactor for an enhanced micropollutant removal. Bioresour Technol 102(9):5319–5324
Nguyen LN, Hai FI, Nghiem LD, Kang J, Price WE, Park C, Yamamoto K (2013) Enhancement of removal of trace organic contaminants by powdered activated carbon dosing into membrane bioreactors. J Taiwan Inst Chem Eng. https://doi.org/10.1016/j.jtice.2013.1005.1021
Serrano D, Suárez S, Lema JM, Omil F (2011) Removal of persistent pharmaceutical micropollutants from sewage by addition of PAC in a sequential membrane bioreactor. Water Res 45(16):5323–5333
Yang W, Paetkau M, Cicek N (2010) Improving the performance of membrane bioreactors by powdered activated carbon dosing with cost considerations. Water Sci Technol 62(1):172–179
Navaratna D, Shu L, Baskaran K, Jegatheesan V (2012) Treatment of ametryn in wastewater by a hybrid MBR system: a lab-scale study. Water Sci Technol 66(6):1317–1324
Nguyen LN, Hai FI, Kang J, Price WE, Nghiem LD (2012) Removal of trace organic contaminants by a membrane bioreactor-granular activated carbon (MBR-GAC) system. Bioresour Technol 113:169–173
Lipp P, Groay H-J, Tiehm A (2012) Improved elimination of organic micropollutants by a process combination of membrane bioreactor (MBR) and powdered activated carbon (PAC). Desalin Water Treat 42(1–3):65–72
Packer JL, Werner JJ, Latch DE, McNeill K, Arnold WA (2003) Photochemical fate of pharmaceuticals in the environment: naproxen, diclofenac, clofibric acid, and ibuprofen. Aquat Sci 65(4):342–351
de Wilt A, van Gijn K, Verhoek T, Vergnes A, Hoek M, Rijnaarts H, Langenhoff A (2018) Enhanced pharmaceutical removal from water in a three step bio-ozone-bio process. Water Res 138:97–105
Ikehata K, Gamal El-Din M, Snyder SA (2008) Ozonation and advanced oxidation treatment of emerging organic pollutants in water and wastewater. Ozone Sci Eng 30(1):21–26
Pollice A, Laera G, Cassano D, Diomede S, Pinto A, Lopez A, Mascolo G (2012) Removal of nalidixic acid and its degradation products by an integrated MBR-ozonation system. J Hazard Mater 203–204:46–52
Laera G, Cassano D, Lopez A, Pinto A, Pollice A, Ricco G, Mascolo G (2012) Removal of organics and degradation products from industrial wastewater by a membrane bioreactor integrated with ozone or UV/H2O2 treatment. Environ Sci Technol 46(2):1010–1018
Mascolo G, Laera G, Pollice A, Cassano D, Pinto A, Salerno C, Lopez A (2010) Effective organics degradation from pharmaceutical wastewater by an integrated process including membrane bioreactor and ozonation. Chemosphere 78(9):1100–1109
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Nguyen, L.N., Commault, A.S., Sutherland, D., Semblante, G.U., Oh, S., Nghiem, L.D. (2020). Contemporary Methods for Removal of Nonsteroidal Anti-inflammatory Drugs in Water Reclamations. In: Gómez-Oliván, L.M. (eds) Non-Steroidal Anti-Inflammatory Drugs in Water. The Handbook of Environmental Chemistry, vol 96. Springer, Cham. https://doi.org/10.1007/698_2020_550
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