Abstract
Hematopoietic stem cells (HSCs) and their development are one of the most widely studied model systems in mammals. In adults, HSCs are predominantly found in the bone marrow, from where they maintain homeostasis. Besides bone marrow and mobilized peripheral blood, cord blood is also being used as an alternate allogenic source of transplantable HSCs. HSCs from both autologous and allogenic sources are being applied for the treatment of various conditions like blood cancers, anemia, etc. HSCs can further differentiate to mature blood cells. Differentiation process of HSCs is being extensively studied so as to obtain a large number of pure populations of various differentiated cells in vitro so that they can be taken up for clinical trials. The ability to generate sufficient quantity of clinical-grade specialized blood cells in vitro would take the field of hematology a step ahead in translational medicine.
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Abbreviations
- BM:
-
bone marrow
- CLP:
-
common lymphoid progenitor
- CMP:
-
common myeloid progenitor
- DCs:
-
dendritic cells
- DMSO:
-
dimethyl sulfoxide
- ESCs:
-
embryonic stem cells
- FCS:
-
fetal calf serum
- GMP:
-
good manufacturing practice
- GvHD:
-
graft-vs-host disease
- HLA:
-
human leukocyte antigen
- HPCs:
-
hematopoietic progenitor cells
- HSCs:
-
hematopoietic stem cells
- iPSCs:
-
induced pluripotent stem cells
- LT-HSCs:
-
long-term-hematopoietic stem cells
- MKs:
-
megakaryocytes
- MNCs:
-
mononuclear cells
- MSCs:
-
mesenchymal stem cells
- PB:
-
peripheral blood
- PSCs:
-
pluripotent stem cells
- RBCs:
-
red blood cells
- Tregs:
-
T regulatory cells
- UCB:
-
umbilical cord blood
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Fernandes, S.S., Limaye, L.S., Kale, V.P. (2021). Differentiated Cells Derived from Hematopoietic Stem Cells and Their Applications in Translational Medicine. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 14. Advances in Experimental Medicine and Biology(), vol 1347. Springer, Cham. https://doi.org/10.1007/5584_2021_644
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