Skip to main content

Telomere Length and Oxidative Stress in Patients with ST-Segment Elevation and Non-ST-Segment Elevation Myocardial Infarction

  • Chapter
  • First Online:
Cell Biology and Translational Medicine, Volume 14

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bas HA, Aksoy F, Icli A et al (2017) The association of plasma oxidative status and inflammation with the development of atrial fibrillation in patients presenting with ST elevation myocardial infarction. Scand J Clin Lab Invest 77(2):77–82

    Article  CAS  PubMed  Google Scholar 

  • Baumgartner H, Hung J, Bermejo J et al (2017) Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European association of cardiovascular imaging and the American society of echocardiography. J Am Soc Echocardiogr 30(4):372–392

    Article  PubMed  Google Scholar 

  • Bekaert S, De Meyer T, Rietzschel ER, De Buyzere ML, De Bacquer D, Langlois M et al (2007) Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. Aging Cell 6(5):639–647

    Article  CAS  PubMed  Google Scholar 

  • Blackburn EH, Epel ES, Lin J (2015) Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection. Science 350(6265):1193–1198

    Article  CAS  PubMed  Google Scholar 

  • Börekçi A, Gür M, Türkoğlu C et al (2016) Oxidative stress and spontaneous reperfusion of infarct-related artery in patients with st-segment elevation myocardial infarction. Clin Appl Thromb Hemost 22(2):171–177

    Article  PubMed  Google Scholar 

  • Calvert PA, Liew TV, Gorenne I et al (2011) Leukocyte telomere length is associated with high-risk plaques on virtual histology intravascular ultrasound and increased proinflammatory activity. Arterioscler Thromb Vasc Biol 31(9):2157–2164

    Article  CAS  PubMed  Google Scholar 

  • Cawthon RM (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res 30(10):e47

    Article  PubMed  PubMed Central  Google Scholar 

  • Cawthon RM, Smith KR, O’Brien E, Sivatchenko A, Kerber RA (2003) Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361(9355):393–395

    Article  CAS  PubMed  Google Scholar 

  • Codd V, Nelson CP, Albrecht E, Mangino M, Deelen J, Buxton JL et al (2013) Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet 45(4):422–427

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • D’Mello MJ, Ross SA, Briel M, Anand SS, Gerstein H, Paré G (2015) Association between shortened leukocyte telomere length and cardiometabolic outcomes: systematic review and meta-analysis. Circ Cardiovasc Genet 8(1):82–90

    Article  PubMed  Google Scholar 

  • Daniali L, Benetos A, Susser E, Kark JD, Labat C, Kimura M et al (2013) Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun 4(1):1597

    Article  PubMed  Google Scholar 

  • De Meyer T, Rietzschel ER, De Buyzere ML, Langlois MR, De Bacquer D, Segers P et al (2009) Systemic telomere length and preclinical atherosclerosis: the Asklepios Study. Eur Heart J 30(24):3074–3081

    Article  PubMed  Google Scholar 

  • Erel O (2004) A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37(4):277–285

    Article  CAS  PubMed  Google Scholar 

  • Erel O (2005) A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38(12):1103–1111

    Article  CAS  PubMed  Google Scholar 

  • Gensini GG (1983) A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 51(3):606

    Article  CAS  PubMed  Google Scholar 

  • Gökdemir MT, Kaya H, Söğüt O, Kaya Z, Albayrak L, Taşkın A (2013) The role of oxidative stress and inflammation in the early evaluation of acute non-ST-elevation myocardial infarction: an observational study. Anadolu Kardiyol Derg 13(2):131–136

    PubMed  Google Scholar 

  • Hamm CW, Bassand JP, Agewall S et al (2011) ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST segment elevation of the European Society of Cardiology (ESC). Eur Heart J 32(23):2999–3054

    Article  PubMed  Google Scholar 

  • Haver VG, Hartman MH, Mateo Leach I et al (2015) Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial. Clin Res Cardiol 104(10):812–821

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Haycock PC, Heydon EE, Kaptoge S, Butterworth AS, Thompson A, Willeit P (2014) Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ 349:g4227

    Article  PubMed  PubMed Central  Google Scholar 

  • Horwitz A (2001) A version of Simpson’s rule for multiple integrals. J Comput Appl Math 134:1–11

    Article  Google Scholar 

  • Judkins MP (1968) Percutaneous transfemoral selective coronary arteriography. Radiol Clin N Am 6(3):467–492

    Article  CAS  PubMed  Google Scholar 

  • Kasap S, Gönenç A, Sener DE, Hisar I (2007) Serum cardiac markers in patients with acute myocardial infarction: oxidative stress, C-reactive protein and N-terminal probrain natriuretic peptide. J Clin Biochem Nutr 41:50–57

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kunadian V, Neely RD, Sinclair H et al (2016) Study to improve cardiovascular outcomes in high-risk older patients (ICON1) with acute coronary syndrome: study design and protocol of a prospective observational study. BMJ Open 6(8):e012091

    Article  PubMed  PubMed Central  Google Scholar 

  • Kundi H, Erel Ö, Balun A, Çiçekçioğlu H, Cetin M, Kiziltunç E, Neşelioğlu S, Topçuoğlu C, Örnek E (2015) Association of thiol/disulfide ratio with syntax score in patients with NSTEMI. Scand Cardiovasc J 49(2):95–100

    Article  CAS  PubMed  Google Scholar 

  • Lavall MC, Bonfanti G, Ceolin RB, Schott KL, Gonçalves Tde L, Moresco RN, Brucker N, Morsch VM, Bagatini MD, Schetinger MR (2016) Oxidative profile of patients with ST segment elevation myocardial infarction. Clin Lab 62(5):971–973

    CAS  PubMed  Google Scholar 

  • Margaritis M, Sanna F, Lazaros G et al (2017) Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress. Eur Heart J 38(41):3094–3104

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Masi S, D’Aiuto F, Cooper J et al (2016) Telomere length, antioxidant status and incidence of ischaemic heart disease in type 2 diabetes. Int J Cardiol 216:159–164

    Article  PubMed  PubMed Central  Google Scholar 

  • Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I (2002) Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 105(13):1541–1544

    Article  CAS  PubMed  Google Scholar 

  • Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, Byrne RA, Collet JP, Falk V, Head SJ, Jüni P, Kastrati A, Koller A, Kristensen SD, Niebauer J, Richter DJ, Seferovic PM, Sibbing D, Stefanini GG, Windecker S, Yadav R, Zembala MO, ESC Scientific Document Group (2019) 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J 40(2):87–165

    Article  PubMed  Google Scholar 

  • Nguyen MT, Fernando S, Schwarz N, Tan JT, Bursill CA, Psaltis PJ (2019) Inflammation as a therapeutic target in atherosclerosis. J Clin Med 8(8):1109

    Article  CAS  PubMed Central  Google Scholar 

  • Ogami M, Ikura Y, Ohsawa M, Matsuo T, Kayo S, Yoshimi N et al (2004) Telomere shortening in human coronary artery diseases. Arterioscler Thromb Vasc Biol 24(3):546–550

    Article  CAS  PubMed  Google Scholar 

  • Opstad TB, Kalstad AA, Pettersen AÅ, Arnesen H, Seljeflot I (2019) Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease. Exp Gerontol 119:53–60

    Article  CAS  PubMed  Google Scholar 

  • Riethman H (2008) Human telomere structure and biology. Annu Rev Genomics Hum Genet 9:1–19

    Article  CAS  PubMed  Google Scholar 

  • Sabharwal S, Verhulst S, Guirguis G, Kark JD, Labat C, Roche NE, Martimucci K, Patel K, Heller DS, Kimura M, Chuang D, Chuang A, Benetos A, Aviv A (2018) Telomere length dynamics in early life: the blood-and-muscle model. FASEB J 32(1):529–534

    Article  CAS  PubMed  Google Scholar 

  • Siti HN, Kamisah Y, Kamsiah J (2015) The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). Vasc Pharmacol 71:40–56

    Article  CAS  Google Scholar 

  • Thygesen K, Alpert JS, Jaffe AS et al (2018) Fourth universal definition of myocardial infarction. J Am Coll Cardiol 72(18):2231–2264

    Article  PubMed  Google Scholar 

  • Turkish Statistical Institute. Causes of Death Statistics, 2018. http://www.tuik.gov.tr/PreHaberBultenleri.do?id=30626. Access Sept 2020

  • Verhoeven JE, Révész D, Epel ES, Lin J, Wolkowitz OM, Penninx BW (2014) Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study. Mol Psychiatry 19(8):895–901

    Article  CAS  PubMed  Google Scholar 

  • Voghel G, Thorin-Trescases N, Farhat N et al (2007) Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors. Mech Ageing Dev 128(11–12):662–671

    Article  CAS  PubMed  Google Scholar 

  • Von Zglinicki T (2002) Oxidative stress shortens telomeres. Trends Biochem Sci 27(7):339–344

    Article  Google Scholar 

  • Yeh JK, Wang CY (2016) Telomeres and telomerase in cardiovascular diseases. Genes (Basel) 7(9):58

    Article  PubMed Central  Google Scholar 

  • Zee RY, Michaud SE, Germer S, Ridker PM (2009) Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach. Clin Chim Acta 403(1–2):139–141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhan Y, Karlsson IK, Karlsson R et al (2017) Exploring the causal pathway from telomere length to coronary heart disease: a network mendelian randomization study. Circ Res 121(3):214–219

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by Yozgat Bozok University, Scientific Research Projects Department (Project Number: 6602c-TF/17-91). We wish to thank Yozgat Bozok University, Scientific Research Projects Department, for their supports and Alperen Timucin SÖNMEZ and Cagla SARITÜRK for their statistical analysis assistance.

Conflict of Interest

The authors report no relationships that could be construed as a conflict of interest.

Authors’ Contributions

All authors read and approved the final version of the manuscript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nihal Inandiklioğlu .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Inandiklioğlu, N., Demir, V., Ercan, M. (2021). Telomere Length and Oxidative Stress in Patients with ST-Segment Elevation and Non-ST-Segment Elevation Myocardial Infarction. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 14. Advances in Experimental Medicine and Biology(), vol 1347. Springer, Cham. https://doi.org/10.1007/5584_2021_638

Download citation

Publish with us

Policies and ethics