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Serum Vitamin D and Immunogenicity of Influenza Vaccination in the Elderly

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Medical Research and Innovation

Part of the book series: Advances in Experimental Medicine and Biology ((CLEXBI,volume 1324))

Abstract

Vaccination is the most effective preventive measure that reduces the risk of influenza and post-influenza complications. It prevents influenza-related hospitalizations and deaths in 50–60% and about 80% of patients aged over 65, respectively. There is the clinical plausibility of the association between serum vitamin D (VIT D) content and viral respiratory infections. In this study, we addressed the issue of a vitamin D modulatory effect on the immune response to seasonal influenza vaccination in elderly persons. The study comprised 96 participants aged 60–75 during the 2016/17 epidemic season. After the determination of the baseline content of VIT D and anti-hemagglutinin antibodies (H1, H3, and HB), participants were vaccinated with a trivalent vaccine. The content of the anti-hemagglutinin antibodies was rechecked 4–5 weeks afterward, showing inappreciable alterations. The negative findings of this study make the influence of serum VIT D content on the immunogenicity of influenza vaccination highly unlikely in elderly persons.

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References

  • Berry DJ, Hesketh K, Power C, Hyppönen E (2011) Vitamin D status has a linear association with seasonal infections and lung function in British adults. Br J Nutr 106:1433–1440

    Article  CAS  Google Scholar 

  • Bratke K, Nielsen J, Manig F, Klein C, Kuepper M, Geyer S, Julius P, Lommatzsch M, Virchow JC (2010) Functional expression of granzyme B in human plasmacytoid dendritic cells: a role in allergic inflammation. Clin Exp Allergy 40(7):1015–1024

    Article  CAS  Google Scholar 

  • Chadha MK, Fakih M, Muindi J, Tian L, Mashtare T, Johnson CS, Trump D (2011) Effect of 25-hydroxyvitamin D status on serological response to influenza vaccine in prostate cancer patients. Prostate 71:368–372

    Article  CAS  Google Scholar 

  • Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M (2014) Impact of vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol 5:151

    Article  Google Scholar 

  • Daynes RA, Araneo BA (1994) The development of effective vaccine adjuvants employing natural regulators of T-cell lymphokine production in vivo. Ann N Y Acad Sci 730:144–161

    Article  CAS  Google Scholar 

  • Daynes RA, Enioutina EY, Butler S, Mu HH, McGee ZA, Araneo A (1996) Induction of common mucosal immunity by hormonally immunomodulated peripheral immunization. Infect Immun 64:1100–1109

    Article  CAS  Google Scholar 

  • Deguchi Y, Takasug Y (2000) Efficacy of influenza vaccine in the elderly: reduction in risks of mortality and morbidity during an influenza A (H3N2) epidemic for the elderly in nursing homes. Int J Clin Lab Res 30(1):1–4

    Article  CAS  Google Scholar 

  • Enioutina EY, Visic D, McGee ZA, Daynes RA (1999) The induction of systemic and mucosal immune responses following the subcutaneous immunization of mature adult mice: characterization of the antibodies in mucosal secretions of animals immunized with antigen formulations containing a vitamin D3 adjuvant. Vaccine 17:3050–3064

    Article  CAS  Google Scholar 

  • Ginde AA, Mansbach JM, Camargo CA Jr (2009) Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med 169:384–390

    Article  CAS  Google Scholar 

  • Goodwin K, Viboud C, Simonsen L (2006) Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 24:1159–1169

    Article  CAS  Google Scholar 

  • Grohskopf AL, Sokolow LZ, Broder KR, Walter EB, Bresee JS, Fry AM, Jernigan DB (2017) Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices – United States, 2017-18 influenza season. MMWR Recomm Rep 66(2):1–20

    Article  Google Scholar 

  • Heine G, Drozdenko G, Lahl A, Unterwalder N, Mei H, Volk HD, Dörner T, Radbruch A, Worm M (2011) Efficient tetanus toxoid immunization on vitamin D supplementation. Eur J Clin Nutr 65:329–334

    Article  CAS  Google Scholar 

  • Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266–281

    Article  CAS  Google Scholar 

  • Ivanov AP, Dragunsky EM, Chumakov KM (2006) 1,25-dihydroxy vitamin D3 enhances systemic and mucosal immune responses to inactivated poliovirus vaccine in mice. J Infect Dis 193:598–600

    Article  CAS  Google Scholar 

  • Jahrsdorfer B, Vollmer A, Blackwell SE, Griffin MR, Spencer S, Shay DK, Coleman LA (2010) Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion. Blood 115:1156–1165

    Article  Google Scholar 

  • Kostova D, Reed C, Finelli L, Cheng PY, Gargiullo PM, Shay DK, Singleton JA, Meltzer MI, Lu PJ, Bresee JS (2013) Influenza illness and hospitalizations averted by influenza vaccination in the United States, 2005–2011. PLoS One 8(6):e66312

    Article  CAS  Google Scholar 

  • Kowalczyk D, Szymański K, Cieślak K, Hallmann-Szelińska E, Brydak LB (2018) Respiratory infections with particular emphasis on influenza virus activity in persons over 14 years of age in the epidemic season 2016/2017 in Poland. Adv Exp Med Biol 1108:75–80

    Article  CAS  Google Scholar 

  • Laaksi I, Ruohola JP, Tuohimaa P, Auvinen A, Haataja R, Pihlajamäki H, Ylikomi T (2007) An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men. Am J Clin Nutr 86:714–717

    Article  CAS  Google Scholar 

  • Lalor MK, Floyd S, Gorak-Stolinska P, Weir RE, Blitz R, Branson K, Fine PE, Dockrell HM (2011) BCG vaccination: a role for vitamin D? PLoS One 6(1):e16709

    Article  CAS  Google Scholar 

  • Lang PO, Aspinall R (2015) Can we translate vitamin D immunomodulating effect on innate and adaptive immunity to vaccine response? Nutrients 7:2044–2060

    Article  CAS  Google Scholar 

  • Lang PO, Samaras D (2012) Aging adults and seasonal influenza: does the vitamin D status (H) arm the body? J Aging Res 2012:806198

    Article  Google Scholar 

  • Łuniewska K, Szymański K, Hallmann-Szelińska E, Kowalczyk D, Sałamatin R, Masny A, Brydak LB (2019) Evaluation of the 2017/18 influenza epidemic season in Poland based on the SENTINEL surveillance system. Adv Exp Med Biol 1222:63–68

    Article  Google Scholar 

  • Martineau AR, Jolliffe DA, Hooper RL et al (2017) Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 356:i6583

    Article  Google Scholar 

  • McElhaney JE, Gravenstein S, Upshaw CM, Hooton JW, Krause P, Drinka P, Bleackley RC (2001) Granzyme B: a marker of risk for influenza in institutionalized older adults. Vaccine 19:3744–3751

    Article  CAS  Google Scholar 

  • McElhaney JE, Xie D, Hager WD, Barry MB, Wang Y, Kleppinger A, Ewen C, Kane KP, Bleackley RC (2006) T cell responses are better correlates of vaccine protection in the elderly. J Immunol 176:6333–6339

    Article  CAS  Google Scholar 

  • Mereckiene J, Cotter S, D’Ancona F, Giambi C, Nicoll A, Levy-Bruhl D, Lopalco PL, Weber JT, Johansen K, Dematte L, Salmaso S, Stefanoff P, Greco D, Dorleans F, Polkowska A, O’Flanagan D, VENICE project gatekeepers group (2010) Differences in national influenza vaccination policies across the European Union, Norway and Iceland 2008-2009. Euro Surveill 15(44):19700

    Article  Google Scholar 

  • Principi N, Marchisio P, Terranova L, Zampiero A, Baggi E, Daleno C, Tirelli S, Pelucchi C, Esposito S (2013) Impact of vitamin D administration on immunogenicity of trivalent inactivated influenza vaccine in previously unvaccinated children. Hum Vaccin Immunother 9(5):969–974

    Article  CAS  Google Scholar 

  • Pyrżak B, Witkowska-Sędek E, Krajewska M, Demkow U, Kucharska AM (2015) Metabolic and immunological consequences of vitamin D deficiency in obese children. Adv Exp Med Biol 840:13–19

    Article  Google Scholar 

  • Sadarangani S, Whitaker JA, Polanda GA (2015) “Let there be light”: the role of vitamin d in the immune response to vaccines. Expert Rev Vaccines 14:1427–1440

    Article  CAS  Google Scholar 

  • Sadarangani SP, Ovsyannikova IG, Goergen K, Grill DE, Poland GA (2016) Vitamin D, leptin and impact on immune response to seasonal influenza A/H1N1 vaccine in older persons. Hum Vaccin Immunother 12:691–698

    Article  Google Scholar 

  • Salk HM, Haralambieva IH, Ovsyannikova G, Goergen KM, Poland GA (2013) Granzyme B ELISPOT assay to measure influenza-specific cellular immunity. J Immunol Methods 398–399:44–50

    Article  Google Scholar 

  • Science M, Maguire J, Russell ML, Smieja M, Walter SD, Loeb M (2014) Serum 25-hydroxyvitamin d level and influenza vaccine immunogenicity in children and adolescents. PLoS One 9(1):e83553

    Article  Google Scholar 

  • Shahid Z, Kleppinger A, Gentleman B, Falsey AR, McElhaney JE (2010) Clinical and immunologic predictors of influenza illness among vaccinated older adults. Vaccine 28:6145–6151

    Article  Google Scholar 

  • Skrobot A, Demkow U, Wachowska M (2018) Immunomodulatory role of vitamin D: a review. Adv Exp Med Biol 1108:13–23

    Article  CAS  Google Scholar 

  • Sundaram ME, Coleman LA (2012) Vitamin D and influenza. Adv Nutr 3(4):517–525

    Article  CAS  Google Scholar 

  • Sundaram ME, Talbot HK, Zhu Y, Griffin MR, Spencer S, Shay DK, Coleman LA (2013) Vitamin D is not associated with serologic response to influenza vaccine in adults over 50 years old. Vaccine 31:2057–2061

    Article  CAS  Google Scholar 

  • Szymański K, Kowalczyk D, Cieślak K, Hallmann-Szelińska E, Brydak LB (2018) Infections with influenza A/H3N2/ subtype in Poland in the 2016/2017 epidemic season. Adv Exp Med Biol 1108:93–98

    Article  Google Scholar 

  • Theeten H, Mathei C, Peeters K, Ogunjimi B, Goossens H, Ieven M, Van Damme P, Cools N (2016) Cellular interferon-gamma and Granzyme B responses to cytomegalovirus pp65 and influenza N1 are positively associated in elderly. Viral Immunol 29:169–175

    Article  CAS  Google Scholar 

  • United Nations (2012) Population ageing and development. https://www.un.org/development/desa/pd/. Accessed on 15 Aug 2020

  • Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H (2010) Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 91:1255–1260

    Article  CAS  Google Scholar 

  • Van der Stede Y, Verfaillie T, Cox E, Verdonck F, Goddeeris BM (2004) 1-alpha,25-dihydroxy vitamin D3 increases IgA serum antibody responses and IgA antibody-secreting cell numbers in the Peyer’s patches of pigs after intramuscular immunization. Clin Exp Immunol 135:380–390

    Article  Google Scholar 

Download references

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study protocol was accepted by the Bioethics Committee of the Wrocław Medical University in Poland.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Authors and Affiliations

  1. Family Doctor’s Practice Slawin Ltd., Kielczow, Poland

    Agata Sławin

  2. Department of Influenza Research, National Influenza Center, National Institute of Public Health- National Institute of Hygiene, Warsaw, Poland

    Lidia B. Brydak

  3. Department of Pneumonology, Institute of Tuberculosis and Lung Diseases, Rabka-Branch, Rabka-Zdroj, Poland

    Zbigniew Doniec

  4. Department of Family Medicine, Wroclaw Medical University, Wroclaw, Poland

    Maria Bujnowska-Fedak & Agnieszka Mastalerz-Migas

Authors
  1. Agata Sławin
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  2. Lidia B. Brydak
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  3. Zbigniew Doniec
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  4. Maria Bujnowska-Fedak
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  5. Agnieszka Mastalerz-Migas
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Corresponding author

Correspondence to Agnieszka Mastalerz-Migas .

Editor information

Editors and Affiliations

  1. Opole Medical School, Opole, Poland

    Mieczyslaw Pokorski

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Sławin, A., Brydak, L.B., Doniec, Z., Bujnowska-Fedak, M., Mastalerz-Migas, A. (2020). Serum Vitamin D and Immunogenicity of Influenza Vaccination in the Elderly. In: Pokorski, M. (eds) Medical Research and Innovation. Advances in Experimental Medicine and Biology(), vol 1324. Springer, Cham. https://doi.org/10.1007/5584_2020_580

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